prodigiosin

naturalproductmech:mibig-d764a5151a MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	WKGQSEFBQTWRPT-UUPRNIFOSA-N
SMILES	CCCCCC1=C(NC(=C1)/C=C\2/C(=C/C(=C/3\C=CC=N3)/N2)OC)C
Stereochemistry	fully defined
Cross-references	pubchem:5351169

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 3

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Serratia sp. Strain: ATCC 39006 NCBITaxon:616	SOURCE_ASSERTION	mibig:BGC0000258	PMID:15528645, DOI:10.1099/mic.0.27222-0 reference PMID:15528645 evidence type DATABASE_ASSERTION notes MIBiG BGC0000258 entry version 3; citation taken from the entry level reference DOI:10.1099/mic.0.27222-0 evidence type CURATOR_INFERENCE notes Strain context: ATCC 39006. Harris et al. identify the Serratia sp. producer as ATCC 39006 in the abstract. This strain is not silently reassigned to S. marcescens. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000258:1; SHA256 d2b8987923a920a62edb3396dd645f055e938a3c1354525f573bc9da4ba0d1b0. Curator: codex; date: 2026-10-13.
Serratia marcescens Strain: ATCC 274 NCBITaxon:615	SOURCE_ASSERTION	mibig:BGC0000259	PMID:15528645, DOI:10.1099/mic.0.27222-0 reference PMID:15528645 evidence type DATABASE_ASSERTION notes MIBiG BGC0000259 entry version 3; citation taken from the entry level reference DOI:10.1099/mic.0.27222-0 evidence type CURATOR_INFERENCE notes Strain context: ATCC 274. Harris et al. identify the S. marcescens producer as ATCC 274 in the abstract; strain context does not upgrade the imported locus evidence. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000259:1; SHA256 c1b490002649033ac44b016b795154c692eb90214d7c3c59871937443bb8bc0b. Curator: codex; date: 2026-10-13.
Hahella chejuensis KCTC 2396 NCBITaxon:349521	SOURCE_ASSERTION	mibig:BGC0000260	PMID:17381736

Occurrences 14

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Hahella chejuensis NCBITaxon:158327	LOTUS	DOI:10.1111/J.1365-2672.2006.03172.X
Streptomyces albidoflavus NCBITaxon:1886	LOTUS	DOI:10.1007/S10482-012-9772-5
Streptomyces albidoflavus NCBITaxon:1886	LOTUS	DOI:10.1007/S11033-018-4324-3
Streptomyces albidoflavus NCBITaxon:1886	LOTUS	DOI:10.1007/S11427-017-9117-X
Streptomyces albidoflavus NCBITaxon:1886	LOTUS	DOI:10.1099/00221287-131-9-2431
Streptomyces albidoflavus NCBITaxon:1886	LOTUS	DOI:10.1128/JB.00017-11
Streptomyces coelicolor NCBITaxon:1902	LOTUS	DOI:10.1007/S10482-012-9772-5
Streptomyces coelicolor NCBITaxon:1902	LOTUS	DOI:10.1007/S11033-018-4324-3
Streptomyces coelicolor NCBITaxon:1902	LOTUS	DOI:10.1007/S11427-017-9117-X
Streptomyces coelicolor NCBITaxon:1902	LOTUS	DOI:10.1099/00221287-131-9-2431
Streptomyces coelicolor NCBITaxon:1902	LOTUS	DOI:10.1128/JB.00017-11
Streptomyces griseoviridis NCBITaxon:45398	LOTUS	DOI:10.1038/JA.2009.27
Streptomyces olivaceus NCBITaxon:47716	LOTUS	DOI:10.1007/BF00411284
Serratia marcescens NCBITaxon:615	LOTUS	DOI:10.1099/MIC.0.27222-0

Biosynthetic gene clusters 3

Accession	Host	Locus evidence	Genome
mibig:BGC0000258	Serratia sp. NCBITaxon:616	CLUSTER_UNSTATED	genbank:AJ833001.1
mibig:BGC0000259	Serratia marcescens NCBITaxon:615	CLUSTER_UNSTATED	genbank:AJ833002.1
mibig:BGC0000260	Hahella chejuensis KCTC 2396 NCBITaxon:349521	CLUSTER_UNSTATED	genbank:DQ266254.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Explore across X-Mech

AntibioticMech (prodigiosin) ↗ MediaIngredientMech (naturalproductmech:mibig-d764a5151a) ↗ TaxonMech: Serratia sp. (NCBITaxon:616) ↗ TaxonMech: Serratia marcescens (NCBITaxon:615) ↗ TaxonMech: Hahella chejuensis KCTC 2396 (NCBITaxon:349521) ↗ PathwayMech (mibig:BGC0000258) ↗ PathwayMech (mibig:BGC0000259) ↗ PathwayMech (mibig:BGC0000260) ↗

Open questions 1

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000258, BGC0000259, BGC0000260. Confirm they describe the same compound rather than an upstream cross-reference error.

Provenance

Source concept	Source	Version
BGC0000258	MIBIG	3
BGC0000259	MIBIG	3
BGC0000260	MIBIG	3

This page is generated from data/natural_products/alkaloids/prodigiosin-2.yaml, which is generated from the committed inventories. Neither is edited by hand.