capsular polysaccharide

naturalproductmech:mibig-ffbecb0bfb MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	NOVHANKYCIGDMV-KSYJWRBWSA-N
SMILES	CC(=O)N[C@@H]1[C@H](C[C@@](O[C@H]1[C@@H]([C@@H](CO)O)O)(C(=O)O)O[C@H]2[C@H]([C@H](O[C@H]([C@@H]2O)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)NC(=O)C)OC[C@@H]4[C@H]([C@@H]([C@H]([C@H](O4)O[C@H]5[C@H](O[C@H]([C@@H]([C@H]5O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)O)O[C@@H]7[C@H](O[C@H]([C@@H]([C@H]7O)O)O)CO)CO)O)O)O)CO)CO)O)O
Stereochemistry	fully defined
Cross-references	pubchem:3083207

Filing pathway

Carbohydrates — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is saccharide, from MIBiG.

Producer organisms 9

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptococcus agalactiae Strain: 090 NCBITaxon:1311	SOURCE_ASSERTION	mibig:BGC0000740	PMID:11773119, https://www.ncbi.nlm.nih.gov/nuccore/AF332893.1 reference PMID:11773119 evidence type DATABASE_ASSERTION notes MIBiG BGC0000740 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AF332893.1 evidence type CURATOR_INFERENCE notes Strain context: 090. GenBank AF332893.1 source feature identifies strain 090 and serotype Ia. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #936. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000740:1; SHA256 cfc37dcdd41f1c2c33b46c28b7d9cc485e204f68d5071e70f6f15efcba1fa1f0. Curator: codex; date: 2026-10-13.
Streptococcus agalactiae Strain: M781 NCBITaxon:1311	SOURCE_ASSERTION	mibig:BGC0000741	PMID:11773119, https://www.ncbi.nlm.nih.gov/nuccore/AF332896.1 reference PMID:11773119 evidence type DATABASE_ASSERTION notes MIBiG BGC0000741 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AF332896.1 evidence type CURATOR_INFERENCE notes Strain context: M781. GenBank AF332896.1 source feature identifies strain M781 and serotype III. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #936. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000741:1; SHA256 f2de6def18f4e15e5c00a98f99f0fc54329f5e79e4e7eafa3d6f3b218a74de4c. Curator: codex; date: 2026-10-13.
Streptococcus agalactiae Strain: SS1214 NCBITaxon:1311	SOURCE_ASSERTION	mibig:BGC0000742	PMID:11773119, https://www.ncbi.nlm.nih.gov/nuccore/AF332901.1 reference PMID:11773119 evidence type DATABASE_ASSERTION notes MIBiG BGC0000742 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AF332901.1 evidence type CURATOR_INFERENCE notes Strain context: SS1214. GenBank AF332901.1 source feature identifies strain SS1214 and serotype VI. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #936. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000742:1; SHA256 e3787528667cfa14e720da07ebc12859460d941e321687884a82062b9d6c9e9e. Curator: codex; date: 2026-10-13.
Streptococcus agalactiae Strain: Prague 118754 NCBITaxon:1311	SOURCE_ASSERTION	mibig:BGC0000743	PMID:11773119, https://www.ncbi.nlm.nih.gov/nuccore/AF332902.1 reference PMID:11773119 evidence type DATABASE_ASSERTION notes MIBiG BGC0000743 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AF332902.1 evidence type CURATOR_INFERENCE notes Strain context: Prague 118754. GenBank AF332902.1 source feature identifies strain Prague 118754 and serotype VI. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #936. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000743:1; SHA256 30ef73bbc8c350e461a1882ce4289f65ad45c4dcd1abb09056ae00564516aad3. Curator: codex; date: 2026-10-13.
Streptococcus agalactiae Strain: SG99/143 NCBITaxon:1311	SOURCE_ASSERTION	mibig:BGC0000744	PMID:11773119, https://www.ncbi.nlm.nih.gov/nuccore/AF363055.1 reference PMID:11773119 evidence type DATABASE_ASSERTION notes MIBiG BGC0000744 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AF363055.1 evidence type CURATOR_INFERENCE notes Strain context: SG99/143. GenBank AF363055.1 source feature identifies strain SG99/143 and serotype III. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #936. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000744:1; SHA256 d28583372d1d6643d977badfb51218b30a24c4305fb3dac2c857809d9b97b6b7. Curator: codex; date: 2026-10-13.
Streptococcus agalactiae Strain: GB00/031 NCBITaxon:1311	SOURCE_ASSERTION	mibig:BGC0000745	PMID:11773119, https://www.ncbi.nlm.nih.gov/nuccore/AF363056.1 reference PMID:11773119 evidence type DATABASE_ASSERTION notes MIBiG BGC0000745 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AF363056.1 evidence type CURATOR_INFERENCE notes Strain context: GB00/031. GenBank AF363056.1 source feature identifies strain GB00/031 and serotype III. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #936. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000745:1; SHA256 f0745814dffcfa54b7fc474b7a8eaadc331ea4dc37961e0e93ff99d8a2d8df19. Curator: codex; date: 2026-10-13.
Streptococcus agalactiae Strain: GB00/017 NCBITaxon:1311	SOURCE_ASSERTION	mibig:BGC0000746	PMID:11773119, https://www.ncbi.nlm.nih.gov/nuccore/AF363057.1 reference PMID:11773119 evidence type DATABASE_ASSERTION notes MIBiG BGC0000746 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AF363057.1 evidence type CURATOR_INFERENCE notes Strain context: GB00/017. GenBank AF363057.1 source feature identifies strain GB00/017 and serotype Ia. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #936. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000746:1; SHA256 5ea48da0039b14aa2167eeeced0b6ef5b08fa16b3c426f683c24a446e5243635. Curator: codex; date: 2026-10-13.
Streptococcus agalactiae Strain: FP6453 NCBITaxon:1311	SOURCE_ASSERTION	mibig:BGC0000747	PMID:11773119, https://www.ncbi.nlm.nih.gov/nuccore/AF363058.1 reference PMID:11773119 evidence type DATABASE_ASSERTION notes MIBiG BGC0000747 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AF363058.1 evidence type CURATOR_INFERENCE notes Strain context: FP6453. GenBank AF363058.1 source feature identifies strain FP6453 and serotype Ia. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #936. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000747:1; SHA256 2dc92c661ff374cf52c39c2aed89a17989d6c71237e8d0ca79a465d7a757614d. Curator: codex; date: 2026-10-13.
Streptococcus agalactiae Strain: SG99/276 NCBITaxon:1311	SOURCE_ASSERTION	mibig:BGC0000748	PMID:11773119, https://www.ncbi.nlm.nih.gov/nuccore/AF363059.1 reference PMID:11773119 evidence type DATABASE_ASSERTION notes MIBiG BGC0000748 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AF363059.1 evidence type CURATOR_INFERENCE notes Strain context: SG99/276. GenBank AF363059.1 source feature identifies strain SG99/276 and serotype Ia. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #936. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000748:1; SHA256 3bd9460e90d921ab87565ea6b3cd1e94c64e5318fc843c1251d1972c879aef50. Curator: codex; date: 2026-10-13.

Occurrences 0

None cited.

Biosynthetic gene clusters 9

Accession	Host	Locus evidence	Genome
mibig:BGC0000740	Streptococcus agalactiae NCBITaxon:1311	CLUSTER_UNSTATED	genbank:AF332893.1
mibig:BGC0000741	Streptococcus agalactiae NCBITaxon:1311	CLUSTER_UNSTATED	genbank:AF332896.1
mibig:BGC0000742	Streptococcus agalactiae NCBITaxon:1311	CLUSTER_UNSTATED	genbank:AF332901.1
mibig:BGC0000743	Streptococcus agalactiae NCBITaxon:1311	CLUSTER_UNSTATED	genbank:AF332902.1
mibig:BGC0000744	Streptococcus agalactiae NCBITaxon:1311	CLUSTER_UNSTATED	genbank:AF363055.1
mibig:BGC0000745	Streptococcus agalactiae NCBITaxon:1311	CLUSTER_UNSTATED	genbank:AF363056.1
mibig:BGC0000746	Streptococcus agalactiae NCBITaxon:1311	CLUSTER_UNSTATED	genbank:AF363057.1
mibig:BGC0000747	Streptococcus agalactiae NCBITaxon:1311	CLUSTER_UNSTATED	genbank:AF363058.1
mibig:BGC0000748	Streptococcus agalactiae NCBITaxon:1311	CLUSTER_UNSTATED	genbank:AF363059.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Explore across X-Mech

AntibioticMech (capsular polysaccharide) ↗ MediaIngredientMech (naturalproductmech:mibig-ffbecb0bfb) ↗ TaxonMech: Streptococcus agalactiae (NCBITaxon:1311) ↗ TaxonMech: Streptococcus agalactiae (NCBITaxon:1311) ↗ TaxonMech: Streptococcus agalactiae (NCBITaxon:1311) ↗ TaxonMech: Streptococcus agalactiae (NCBITaxon:1311) ↗ PathwayMech (mibig:BGC0000740) ↗ PathwayMech (mibig:BGC0000741) ↗ PathwayMech (mibig:BGC0000742) ↗

Open questions 2

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000740, BGC0000741, BGC0000742, BGC0000743, BGC0000744, BGC0000745, BGC0000746, BGC0000747, BGC0000748. Confirm they describe the same compound rather than an upstream cross-reference error.

curator-capsule-exact-product-assignment — Which exact chemical product does each deposited capsule locus support?

Provenance

Source concept	Source	Version
BGC0000740	MIBIG	3
BGC0000741	MIBIG	3
BGC0000742	MIBIG	3
BGC0000743	MIBIG	3
BGC0000744	MIBIG	3
BGC0000745	MIBIG	3
BGC0000746	MIBIG	3
BGC0000747	MIBIG	3
BGC0000748	MIBIG	3

This page is generated from data/natural_products/carbohydrates/capsular-polysaccharide-3.yaml, which is generated from the committed inventories. Neither is edited by hand.