streptomycin

CHEBI:17076 EXACT SEEDED antibacterialenzyme inhibitortoxin

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. The parent of the streptomycin class

Structure

Standard InChIKey	UCSJYZPVAKXKNQ-HZYVHMACSA-N
SMILES	C[C@H]1[C@@]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC)(C=O)O
Stereochemistry	fully defined
Cross-references	pubchem:19649

Filing pathway

Carbohydrates — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is saccharide, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces griseus subsp. griseus NBRC 13350 NCBITaxon:455632	SOURCE_ASSERTION	mibig:BGC0000724	PMID:18375553

Occurrences 25

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Aspergillus sclerotiorum NCBITaxon:138282	LOTUS	DOI:10.1021/ACS.JNATPROD.5B00961
Lyngbya majuscula NCBITaxon:158786	LOTUS	DOI:10.1021/NP1006839
Senecio NCBITaxon:18794	LOTUS	DOI:10.1021/NP0702741
Streptomyces albidoflavus NCBITaxon:1886	LOTUS	DOI:10.1099/00221287-129-9-2939
Streptomyces albidoflavus NCBITaxon:1886	LOTUS	DOI:10.1111/J.1365-2958.2005.04817.X
Streptomyces albidoflavus NCBITaxon:1886	LOTUS	DOI:10.1128/AEM.00546-13
Streptomyces albidoflavus NCBITaxon:1886	LOTUS	DOI:10.1128/JB.168.1.257-269.1986
Streptomyces bikiniensis NCBITaxon:1896	LOTUS	DOI:10.7164/ANTIBIOTICS.30.404
Streptomyces bikiniensis NCBITaxon:1896	LOTUS	DOI:10.7164/ANTIBIOTICS.38.636
Streptomyces coelicolor NCBITaxon:1902	LOTUS	DOI:10.1099/00221287-129-9-2939
Streptomyces coelicolor NCBITaxon:1902	LOTUS	DOI:10.1111/J.1365-2958.2005.04817.X
Streptomyces coelicolor NCBITaxon:1902	LOTUS	DOI:10.1128/AEM.00546-13
Streptomyces coelicolor NCBITaxon:1902	LOTUS	DOI:10.1128/JB.168.1.257-269.1986
Streptomyces glaucescens NCBITaxon:1907	LOTUS	DOI:10.1046/J.1432-1327.1998.2581059.X
Streptomyces griseus NCBITaxon:1911	LOTUS	DOI:10.1007/BF00211140
Streptomyces griseus NCBITaxon:1911	LOTUS	DOI:10.1007/BF00264220
Streptomyces griseus NCBITaxon:1911	LOTUS	DOI:10.1007/BF00293829
Streptomyces griseus NCBITaxon:1911	LOTUS	DOI:10.1007/BF00330443
Streptomyces griseus NCBITaxon:1911	LOTUS	DOI:10.1016/0304-4165(79)90095-3
Streptomyces griseus NCBITaxon:1911	LOTUS	DOI:10.1016/0378-1119(83)90178-6
Streptomyces griseus NCBITaxon:1911	LOTUS	DOI:10.1016/B978-0-08-025385-5.50022-5
Streptomyces griseus NCBITaxon:1911	LOTUS	DOI:10.1021/BI981949P
Streptomyces griseus NCBITaxon:1911	LOTUS	DOI:10.1021/JA01187A006
Streptomyces griseus NCBITaxon:1911	LOTUS	DOI:10.1038/JA.2009.97
Streptomyces griseus NCBITaxon:1911	LOTUS	DOI:10.1038/SJ.JIM.7000068

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000724	Streptomyces griseus subsp. griseus NBRC 13350 NCBITaxon:455632	CLUSTER_UNSTATED	genbank:AP009493.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 6

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Inhibitors of the vitamin D receptor (VDR): qHTS	OTHER 70.7946 uM; NOT_DETERMINED	Not recorded	pubchem.aid:504847 assay Inhibitors of the vitamin D receptor (VDR): qHTS evidence reference pubchem.aid:504847 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504847, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001017535 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 70.7946 units uM
qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1)	OTHER 39.8107 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1030 assay qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) evidence reference pubchem.aid:1030 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1030, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAP35567 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 39.8107 units uM
qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a	OTHER 17.7828 uM; ACTIVE	Not recorded	pubchem.aid:504332 assay qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a evidence reference pubchem.aid:504332 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504332, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession CAQ07474 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 17.7828 units uM activity class ENZYME_INHIBITOR
CCRIS mutagenicity studies	ACTIVE	Not recorded	pubchem.aid:1259407 assay CCRIS mutagenicity studies evidence reference pubchem.aid:1259407 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1259407, deposited by 22070; assay type Other. call ACTIVE activity class TOXIN
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database	ACTIVE	Not recorded	pubchem.aid:1195 assay DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database evidence reference pubchem.aid:1195 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1195, deposited by EPA DSSTox; assay type Other. call ACTIVE
GENE-TOX mutagenicity studies	ACTIVE	Not recorded	pubchem.aid:1259408 assay GENE-TOX mutagenicity studies evidence reference pubchem.aid:1259408 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1259408, deposited by 22071; assay type Other. call ACTIVE activity class TOXIN

Elsewhere in the fleet

AntibioticMech — CHEBI:17076 (same structure, same inchikey)

Explore across X-Mech

AntibioticMech (streptomycin) ↗ MediaIngredientMech (CHEBI:17076) ↗ TaxonMech: Streptomyces griseus subsp. griseus NBRC 13350 (NCBITaxon:455632) ↗ PathwayMech (mibig:BGC0000724) ↗

Provenance

Source concept	Source	Version
BGC0000724	MIBIG	5
CHEBI:17076	CHEBI	3-star

This page is generated from data/natural_products/carbohydrates/streptomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.