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desferrioxamine B

CHEBI:4356 EXACT SEEDED cytotoxicenzyme inhibitor

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N1-(5-aminopentyl)-N1-hydroxy-N4-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.

Structure

Standard InChIKeyUBQYURCVBFRUQT-UHFFFAOYSA-N
SMILESCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
Stereochemistryfully defined
Cross-referencesnpatlas:NPA09012, pubchem:2973, npatlas:NPA009012

Filing pathway

Fatty acids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 4

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Streptomyces coelicolor A3(2)
NCBITaxon:100226		 BGC_CHARACTERIZED mibig:BGC0000940 PMID:15600304
Streptomyces griseus subsp. griseus NBRC 13350
NCBITaxon:455632		 SOURCE_ASSERTION mibig:BGC0000941 PMID:18375553
Streptomyces argillaceus
NCBITaxon:41951		 SOURCE_ASSERTION mibig:BGC0001453 PMID:29795673
Streptomyces sp.
NCBITaxon:1931		 SOURCE_ASSERTION mibig:BGC0002305 DOI:10.1016/j.tetlet.2018.11.063

Occurrences 25

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.1007/S00253-018-9337-2
Moorea producens
NCBITaxon:1155739		 LOTUS DOI:10.1021/ACS.JNATPROD.6B00051
Streptomyces wadayamensis
NCBITaxon:141454		 LOTUS DOI:10.1128/GENOMEA.00625-14
Streptomyces malaysiense
NCBITaxon:1428626		 LOTUS DOI:10.1038/SREP24247
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1021/JA045774K
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1099/MIC.0.000524
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1111/J.1742-4658.2007.05662.X
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1111/J.1742-4658.2009.07182.X
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1111/J.1751-7915.2010.00232.X
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1128/MBIO.00459-13
Streptomyces coelicolor
NCBITaxon:1902		 LOTUS DOI:10.1021/JA045774K
Streptomyces coelicolor
NCBITaxon:1902		 LOTUS DOI:10.1099/MIC.0.000524
Streptomyces coelicolor
NCBITaxon:1902		 LOTUS DOI:10.1111/J.1742-4658.2007.05662.X
Streptomyces coelicolor
NCBITaxon:1902		 LOTUS DOI:10.1111/J.1742-4658.2009.07182.X
Streptomyces coelicolor
NCBITaxon:1902		 LOTUS DOI:10.1111/J.1751-7915.2010.00232.X
Streptomyces coelicolor
NCBITaxon:1902		 LOTUS DOI:10.1128/MBIO.00459-13
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1128/JB.00204-08
Streptomyces chartreusis
NCBITaxon:1969		 LOTUS DOI:10.1073/PNAS.1715713115
Streptomyces sviceus
NCBITaxon:285530		 CHEBI PMID:33784308
Streptomyces pilosus
NCBITaxon:28893		 LOTUS DOI:10.1128/JB.175.11.3295-3302.1993
Streptomyces pilosus
NCBITaxon:28893		 LOTUS DOI:10.1186/1475-2859-2-5
Streptomyces pilosus
NCBITaxon:28893		 LOTUS DOI:10.3923/PJBS.2010.1151.1155
Streptomyces pilosus
NCBITaxon:28893		 LOTUS DOI:10.3923/PJBS.2010.546.550
Streptomyces pilosus
NCBITaxon:28893		 CHEBI PMID:30701380
Streptomyces lydicus
NCBITaxon:47763		 LOTUS DOI:10.1038/SREP44786

Biosynthetic gene clusters 4

AccessionHostLocus evidenceGenome
mibig:BGC0000940 Streptomyces coelicolor A3(2)
NCBITaxon:100226 		CLUSTER_DEMONSTRATED genbank:AL645882.2
mibig:BGC0000941 Streptomyces griseus subsp. griseus NBRC 13350
NCBITaxon:455632 		CLUSTER_UNSTATED genbank:AP009493.1
mibig:BGC0001453 Streptomyces argillaceus
NCBITaxon:41951 		CLUSTER_UNSTATED genbank:LT989883.1
mibig:BGC0002305 Streptomyces sp.
NCBITaxon:1931 		CLUSTER_UNSTATED genbank:MN509302.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 4 producers (1 causal) 25 cited occurrences BIOSYNTHETIC LOCUS 4 gene clusters 0 curated pathway steps NATURAL PRODUCT desferrioxamine B CHEBI:4356 Fatty acids TARGETS & BIOACTIVITY 0 molecular targets 25 bioactivities · 1 graph

Causal graph — biosynthesis 7 nodes, 6 edges

Streptomyces coelicolor M145 premature-stop genetics. Five-day ISP-2 extract LC-HRMS/MS signals are assigned to free desferrioxamine B, not metal complexes or absolute concentrations. Canonical proteins denote targeted loci, not mutant sequences. No direct catalysis, complete activity loss, protein-specific independence, or quantitative complementation rescue is asserted. Gene-only traces do not distinguish alternative stop alleles.

SubjectPredicateObjectNotesEvidence
desJ premature-stop mutant disrupts_encoding_gene_of DesJ (SCO4048) native reference SCO4048: designed W55* or Q68*; no mutant protein accession assigned. DesJ complement is pGWS1596 in methods but pGWS1586 in S5 Table.
DOI:10.1371/journal.pbio.3003183
DOI:10.1371/journal.pbio.3003183.s013
DOI:10.1371/journal.pbio.3003183.s014
https://www.uniprot.org/uniprotkb/Q9AK69
https://www.ebi.ac.uk/ena/browser/view/AL939118.1
  • reference
    DOI:10.1371/journal.pbio.3003183
    evidence type
    PRIMARY_EXPERIMENT
    notes
    Results 4; mutant construction methods.
  • reference
    DOI:10.1371/journal.pbio.3003183.s013
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S5 Table: constructs; plasmid-name disagreements retained above.
  • reference
    DOI:10.1371/journal.pbio.3003183.s014
    evidence type
    CURATOR_INFERENCE
    notes
    S6 Table guide and check-primer sequences map uniquely in AL939118.1; target codons permit stop-generating base edits. Complement primers replace the native stop with TAA without changing translated residues.
  • reference
    https://www.uniprot.org/uniprotkb/Q9AK69
    evidence type
    DATABASE_ASSERTION
    notes
    Unreviewed SCO4048, taxon 100226 (A3(2)/M145), 241 aa, sequence version 1; EMBL protein CAC32319.1. Automated functional annotations are not adopted.
    retrieved on
    2026-10-10
  • reference
    https://www.ebi.ac.uk/ena/browser/view/AL939118.1
    evidence type
    CURATOR_INFERENCE
    notes
    CAC32319.1: full native CDS translation under table 11 equals Q9AK69. Reference matching does not sequence the experimental stock.
desJ premature-stop mutant increases_assigned_LC_MS_signal_of desferrioxamine B Genetic metabolite-profile comparison, not purified enzyme activity. Native desG/desH coding intervals overlap by eight bases; polar effects, bystander edits and pathway compensation are not excluded.
DOI:10.1371/journal.pbio.3003183
DOI:10.1371/journal.pbio.3003183.s004
DOI:10.1371/journal.pbio.3003183.s012
DOI:10.1371/journal.pbio.3003183.s002
https://www.ebi.ac.uk/ena/browser/view/AL939118.1
  • reference
    DOI:10.1371/journal.pbio.3003183
    evidence type
    PRIMARY_EXPERIMENT
    notes
    Results 4, Fig 3a; extraction and LC-MS methods.
    snippet
    only the levels of DFO B
  • reference
    DOI:10.1371/journal.pbio.3003183.s004
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S4 Fig: genotype-labelled extracted-ion chromatograms.
  • reference
    DOI:10.1371/journal.pbio.3003183.s012
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S4 Table: free B [M+H]+, predicted 561.3606 m/z. Metal-bound/adduct channels are not this compound node.
  • reference
    DOI:10.1371/journal.pbio.3003183.s002
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S2 Fig B spectrum: cosine 0.7741; figure library CCMSLIB00003135712 differs from caption CCMSLIB00001059066. The author-assigned DFO B signal is retained with this discrepancy, not independently reidentified.
  • reference
    https://www.ebi.ac.uk/ena/browser/view/AL939118.1
    evidence type
    CURATOR_INFERENCE
    notes
    Coordinate comparison: SCO4049 213677..216025(+); SCO4050 216018..216638(+); eight shared bases. Reference geometry does not demonstrate polar effects.
desG premature-stop mutant disrupts_encoding_gene_of DesG (SCO4049) native reference SCO4049: designed W61*; no mutant protein accession assigned.
DOI:10.1371/journal.pbio.3003183
DOI:10.1371/journal.pbio.3003183.s013
DOI:10.1371/journal.pbio.3003183.s014
https://www.uniprot.org/uniprotkb/Q9AK68
https://www.ebi.ac.uk/ena/browser/view/AL939118.1
  • reference
    DOI:10.1371/journal.pbio.3003183
    evidence type
    PRIMARY_EXPERIMENT
    notes
    Results 4; mutant construction methods.
  • reference
    DOI:10.1371/journal.pbio.3003183.s013
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S5 Table: constructs; plasmid-name disagreements retained above.
  • reference
    DOI:10.1371/journal.pbio.3003183.s014
    evidence type
    CURATOR_INFERENCE
    notes
    S6 Table guide and check-primer sequences map uniquely in AL939118.1; target codons permit stop-generating base edits. Complement primers replace the native stop with TAA without changing translated residues.
  • reference
    https://www.uniprot.org/uniprotkb/Q9AK68
    evidence type
    DATABASE_ASSERTION
    notes
    Unreviewed SCO4049, taxon 100226 (A3(2)/M145), 782 aa, sequence version 1; EMBL protein CAC32320.1. Automated functional annotations are not adopted.
    retrieved on
    2026-10-10
  • reference
    https://www.ebi.ac.uk/ena/browser/view/AL939118.1
    evidence type
    CURATOR_INFERENCE
    notes
    CAC32320.1: full native CDS translation under table 11 equals Q9AK68. Reference matching does not sequence the experimental stock.
desG premature-stop mutant decreases_assigned_LC_MS_signal_of desferrioxamine B Genetic metabolite-profile comparison, not purified enzyme activity. Native desG/desH coding intervals overlap by eight bases; polar effects, bystander edits and pathway compensation are not excluded.
DOI:10.1371/journal.pbio.3003183
DOI:10.1371/journal.pbio.3003183.s004
DOI:10.1371/journal.pbio.3003183.s012
DOI:10.1371/journal.pbio.3003183.s002
https://www.ebi.ac.uk/ena/browser/view/AL939118.1
  • reference
    DOI:10.1371/journal.pbio.3003183
    evidence type
    PRIMARY_EXPERIMENT
    notes
    Results 4, Fig 3a; extraction and LC-MS methods.
  • reference
    DOI:10.1371/journal.pbio.3003183.s004
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S4 Fig: genotype-labelled extracted-ion chromatograms.
  • reference
    DOI:10.1371/journal.pbio.3003183.s012
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S4 Table: free B [M+H]+, predicted 561.3606 m/z. Metal-bound/adduct channels are not this compound node.
  • reference
    DOI:10.1371/journal.pbio.3003183.s002
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S2 Fig B spectrum: cosine 0.7741; figure library CCMSLIB00003135712 differs from caption CCMSLIB00001059066. The author-assigned DFO B signal is retained with this discrepancy, not independently reidentified.
  • reference
    https://www.ebi.ac.uk/ena/browser/view/AL939118.1
    evidence type
    CURATOR_INFERENCE
    notes
    Coordinate comparison: SCO4049 213677..216025(+); SCO4050 216018..216638(+); eight shared bases. Reference geometry does not demonstrate polar effects.
desH premature-stop mutant disrupts_encoding_gene_of DesH (SCO4050) native reference SCO4050: designed W43* or Q91*; no mutant protein accession assigned. W43* vector is pGWS1598 in methods but pGWS1589 in S5 Table; pGWS1598 also names the complement.
DOI:10.1371/journal.pbio.3003183
DOI:10.1371/journal.pbio.3003183.s013
DOI:10.1371/journal.pbio.3003183.s014
https://www.uniprot.org/uniprotkb/Q9AK67
https://www.ebi.ac.uk/ena/browser/view/AL939118.1
  • reference
    DOI:10.1371/journal.pbio.3003183
    evidence type
    PRIMARY_EXPERIMENT
    notes
    Results 4; mutant construction methods.
  • reference
    DOI:10.1371/journal.pbio.3003183.s013
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S5 Table: constructs; plasmid-name disagreements retained above.
  • reference
    DOI:10.1371/journal.pbio.3003183.s014
    evidence type
    CURATOR_INFERENCE
    notes
    S6 Table guide and check-primer sequences map uniquely in AL939118.1; target codons permit stop-generating base edits. Complement primers replace the native stop with TAA without changing translated residues.
  • reference
    https://www.uniprot.org/uniprotkb/Q9AK67
    evidence type
    DATABASE_ASSERTION
    notes
    Unreviewed SCO4050, taxon 100226 (A3(2)/M145), 206 aa, sequence version 1; EMBL protein CAC32321.1. Automated functional annotations are not adopted.
    retrieved on
    2026-10-10
  • reference
    https://www.ebi.ac.uk/ena/browser/view/AL939118.1
    evidence type
    CURATOR_INFERENCE
    notes
    CAC32321.1: full native CDS translation under table 11 equals Q9AK67. Reference matching does not sequence the experimental stock.
desH premature-stop mutant decreases_assigned_LC_MS_signal_of desferrioxamine B Genetic metabolite-profile comparison, not purified enzyme activity. Native desG/desH coding intervals overlap by eight bases; polar effects, bystander edits and pathway compensation are not excluded.
DOI:10.1371/journal.pbio.3003183
DOI:10.1371/journal.pbio.3003183.s004
DOI:10.1371/journal.pbio.3003183.s012
DOI:10.1371/journal.pbio.3003183.s002
https://www.ebi.ac.uk/ena/browser/view/AL939118.1
  • reference
    DOI:10.1371/journal.pbio.3003183
    evidence type
    PRIMARY_EXPERIMENT
    notes
    Results 4, Fig 3a; extraction and LC-MS methods.
  • reference
    DOI:10.1371/journal.pbio.3003183.s004
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S4 Fig: genotype-labelled extracted-ion chromatograms.
  • reference
    DOI:10.1371/journal.pbio.3003183.s012
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S4 Table: free B [M+H]+, predicted 561.3606 m/z. Metal-bound/adduct channels are not this compound node.
  • reference
    DOI:10.1371/journal.pbio.3003183.s002
    evidence type
    PRIMARY_EXPERIMENT
    notes
    S2 Fig B spectrum: cosine 0.7741; figure library CCMSLIB00003135712 differs from caption CCMSLIB00001059066. The author-assigned DFO B signal is retained with this discrepancy, not independently reidentified.
  • reference
    https://www.ebi.ac.uk/ena/browser/view/AL939118.1
    evidence type
    CURATOR_INFERENCE
    notes
    Coordinate comparison: SCO4049 213677..216025(+); SCO4050 216018..216638(+); eight shared bases. Reference geometry does not demonstrate polar effects.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

AssayResultTarget enzymeSource detail
A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells.OTHER 0.1458 uM; NOT_DETERMINEDNot recorded
pubchem.aid:624296
assay
A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells.
evidence
  • reference
    pubchem.aid:624296
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624296, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_056979 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
0.1458
units
uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: AML-191 cell lineOTHER 8.3275 uM; ACTIVENot recorded
pubchem.aid:2202236
assay
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: AML-191 cell line
evidence
  • reference
    pubchem.aid:2202236
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202236, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
8.3275
units
uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: AML-194 cell lineOTHER 9.3436 uM; ACTIVENot recorded
pubchem.aid:2202237
assay
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: AML-194 cell line
evidence
  • reference
    pubchem.aid:2202237
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202237, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
9.3436
units
uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: HNT-34 cell lineOTHER 9.3436 uM; ACTIVENot recorded
pubchem.aid:2202234
assay
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: HNT-34 cell line
evidence
  • reference
    pubchem.aid:2202234
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202234, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
9.3436
units
uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: MV-4-11 cell lineOTHER 11.7629 uM; ACTIVENot recorded
pubchem.aid:2202233
assay
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: MV-4-11 cell line
evidence
  • reference
    pubchem.aid:2202233
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202233, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
11.7629
units
uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: OCI-AML3 cell lineOTHER 11.7629 uM; ACTIVENot recorded
pubchem.aid:2202232
assay
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: OCI-AML3 cell line
evidence
  • reference
    pubchem.aid:2202232
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202232, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
11.7629
units
uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: SET-2 cell lineOTHER 20.9177 uM; ACTIVENot recorded
pubchem.aid:2202231
assay
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: SET-2 cell line
evidence
  • reference
    pubchem.aid:2202231
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202231, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
20.9177
units
uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: UCSD-AML1 cell lineOTHER 0.8327 uM; NOT_DETERMINEDNot recorded
pubchem.aid:2202235
assay
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: UCSD-AML1 cell line
evidence
  • reference
    pubchem.aid:2202235
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202235, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
0.8327
units
uM
Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13OTHER 28.1838 uM; ACTIVENot recorded
pubchem.aid:1963989
assay
Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13
evidence
  • reference
    pubchem.aid:1963989
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963989, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
28.1838
units
uM
activity class
CYTOTOXIC
Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line 8505COTHER 17.4111 uM; ACTIVENot recorded
pubchem.aid:2202553
assay
Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line 8505C
evidence
  • reference
    pubchem.aid:2202553
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202553, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
17.4111
units
uM
activity class
CYTOTOXIC
Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line THJ-11TOTHER 12.3261 uM; ACTIVENot recorded
pubchem.aid:2202552
assay
Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line THJ-11T
evidence
  • reference
    pubchem.aid:2202552
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202552, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
12.3261
units
uM
activity class
CYTOTOXIC
Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line THJ-16TOTHER 13.8302 uM; ACTIVENot recorded
pubchem.aid:2202551
assay
Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line THJ-16T
evidence
  • reference
    pubchem.aid:2202551
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202551, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
13.8302
units
uM
activity class
CYTOTOXIC
Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entryOTHER 25.1189 uM; ACTIVENot recorded
pubchem.aid:1645845
assay
Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
evidence
  • reference
    pubchem.aid:1645845
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645845, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
25.1189
units
uM
activity class
CYTOTOXIC
Nrf2 qHTS screen for inhibitorsOTHER 14.581 uM; NOT_DETERMINEDNot recorded
pubchem.aid:504444
assay
Nrf2 qHTS screen for inhibitors
evidence
  • reference
    pubchem.aid:504444
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 504444, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001138884 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
14.581
units
uM
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2OTHER 50.1187 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1671190
assay
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
evidence
  • reference
    pubchem.aid:1671190
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1671190, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
50.1187
units
uM
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2OTHER 50.1187 uM; NOT_DETERMINEDUniProtKB:P18054
pubchem.aid:1671190
assay
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
evidence
  • reference
    pubchem.aid:1671190
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1671190, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
50.1187
units
uM
target enzyme
UniProtKB:P18054
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)OTHER 4.6829 uM; ACTIVENot recorded
pubchem.aid:1645877
assay
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
evidence
  • reference
    pubchem.aid:1645877
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645877, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
4.6829
units
uM
activity class
ENZYME_INHIBITOR
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)OTHER 4.6829 uM; ACTIVEUniProtKB:O96028
pubchem.aid:1645877
assay
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
evidence
  • reference
    pubchem.aid:1645877
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645877, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
4.6829
units
uM
target enzyme
UniProtKB:O96028
activity class
ENZYME_INHIBITOR
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)OTHER 5.2543 uM; ACTIVENot recorded
pubchem.aid:1645876
assay
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
evidence
  • reference
    pubchem.aid:1645876
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645876, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
5.2543
units
uM
activity class
ENZYME_INHIBITOR
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)OTHER 5.2543 uM; ACTIVEUniProtKB:O96028
pubchem.aid:1645876
assay
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
evidence
  • reference
    pubchem.aid:1645876
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645876, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
5.2543
units
uM
target enzyme
UniProtKB:O96028
activity class
ENZYME_INHIBITOR
Primary qHTS to identify anti-liver cancer compounds using libraries of approved drugs and bioactive compoundsOTHER 11.2202 uM; ACTIVENot recorded
pubchem.aid:2202548
assay
Primary qHTS to identify anti-liver cancer compounds using libraries of approved drugs and bioactive compounds
evidence
  • reference
    pubchem.aid:2202548
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202548, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
11.2202
units
uM
activity class
CYTOTOXIC
Primary qHTS to identify inhibitors of SARS-CoV-2 cell entryOTHER 17.7828 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1645846
assay
Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
evidence
  • reference
    pubchem.aid:1645846
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645846, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
17.7828
units
uM
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cellsOTHER 5.8954 uM; ACTIVENot recorded
pubchem.aid:1963824
assay
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells
evidence
  • reference
    pubchem.aid:1963824
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963824, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
5.8954
units
uM
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cellsOTHER 5.8954 uM; ACTIVEUniProtKB:P43405
pubchem.aid:1963824
assay
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells
evidence
  • reference
    pubchem.aid:1963824
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963824, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
5.8954
units
uM
target enzyme
UniProtKB:P43405
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 cellsOTHER 6.6148 uM; ACTIVENot recorded
pubchem.aid:1963823
assay
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 cells
evidence
  • reference
    pubchem.aid:1963823
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963823, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
6.6148
units
uM
notes
23 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.

Explore across X-Mech

AntibioticMech (desferrioxamine B) ↗ MediaIngredientMech (CHEBI:4356) ↗ TaxonMech: Streptomyces coelicolor A3(2) (NCBITaxon:100226) ↗ TaxonMech: Streptomyces griseus subsp. griseus NBRC 13350 (NCBITaxon:455632) ↗ TaxonMech: Streptomyces argillaceus (NCBITaxon:41951) ↗ TaxonMech: Streptomyces sp. (NCBITaxon:1931) ↗ PathwayMech (mibig:BGC0000940) ↗ PathwayMech (mibig:BGC0000941) ↗ PathwayMech (mibig:BGC0001453) ↗

Open questions 2

name-disagreement — ChEBI calls this structure 'desferrioxamine B' and MIBiG calls it 'desferrioxamin B'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000940, BGC0000941, BGC0001453, BGC0002305. Confirm they describe the same compound rather than an upstream cross-reference error.

Provenance

Source conceptSourceVersion
BGC0000940MIBIG5
BGC0000941MIBIG3
BGC0001453MIBIG5
BGC0002305MIBIG2
CHEBI:4356CHEBI3-star

This page is generated from data/natural_products/fatty_acids/desferrioxamine-b.yaml, which is generated from the committed inventories. Neither is edited by hand.