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erythromycin A

CHEBI:42355 EXACT SEEDED antibacterialcytotoxicenzyme inhibitor

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.

Structure

Standard InChIKeyULGZDMOVFRHVEP-RWJQBGPGSA-N
SMILESCC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O
Stereochemistryfully defined
Cross-referencespubchem:12560, chembl:CHEMBL532

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, saccharide, from MIBiG.

Producer organisms 2

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Saccharopolyspora erythraea NRRL 2338
NCBITaxon:405948		 BGC_CHARACTERIZED mibig:BGC0000055 PMID:11336289
Aeromicrobium erythreum
NCBITaxon:2041		 SOURCE_ASSERTION mibig:BGC0000054 PMID:15257441

Occurrences 14

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Bacillus subtilis
NCBITaxon:1423		 LOTUS DOI:10.1021/ACSCATAL.1C05131
Saccharopolyspora erythraea
NCBITaxon:1836		 LOTUS DOI:10.1016/0021-9673(91)80132-Z
Saccharopolyspora erythraea
NCBITaxon:1836		 LOTUS DOI:10.1016/0040-4039(91)80057-D
Saccharopolyspora erythraea
NCBITaxon:1836		 LOTUS DOI:10.1021/ACSSYNBIO.8B00372
Saccharopolyspora erythraea
NCBITaxon:1836		 LOTUS DOI:10.1248/CPB.42.1522
Saccharopolyspora erythraea
NCBITaxon:1836		 LOTUS DOI:10.7164/ANTIBIOTICS.40.1115
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1021/BI965010K
Streptomyces coelicolor
NCBITaxon:1902		 LOTUS DOI:10.1021/BI965010K
Streptomyces hygroscopicus
NCBITaxon:1912		 LOTUS DOI:10.1021/NP400145U
Streptomyces lydicus
NCBITaxon:47763		 LOTUS DOI:10.1007/BF00873025
Streptomyces lydicus
NCBITaxon:47763		 LOTUS DOI:10.1038/SREP44786
Streptomyces lydicus
NCBITaxon:47763		 LOTUS DOI:10.4103/0250-474X.42979
Pseudoalteromonas
NCBITaxon:53246		 LOTUS DOI:10.1021/NP500775E
Aeromicrobium erythreum
NCBITaxon:2041		 LOTUS DOI:10.1007/S10295-004-0154-5

Biosynthetic gene clusters 2

AccessionHostLocus evidenceGenome
mibig:BGC0000055 Saccharopolyspora erythraea NRRL 2338
NCBITaxon:405948 		CLUSTER_DEMONSTRATED genbank:AM420293.1
mibig:BGC0000054 Aeromicrobium erythreum
NCBITaxon:2041 		CLUSTER_UNSTATED genbank:AY623658.2

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Biosynthesis curated

Written by a curator with claim-level evidence on each step; not derived from a source. This is what the rest of the record exists to support.

StepEnzymeReactionSubstrate → productEvidence
10 EryF 6-deoxyerythronolide B hydroxylase
UniProtKB:Q00441		 RHEA:40299 CHEBI:16089 → CHEBI:27977 DOI:10.1128/jb.174.3.725-735.1992
20 EryK erythromycin C-12 hydroxylase
UniProtKB:P48635		 RHEA:32631 CHEBI:63677 → CHEBI:64258 DOI:10.1021/bi00006a006
30 EryG erythromycin 3''-O-methyltransferase
UniProtKB:A4F7P5		 RHEA:32647 CHEBI:64258 → CHEBI:64268 DOI:10.1128/jb.172.5.2541-2546.1990

Step 10: Partial tailoring view: EryF hydroxylates 6-deoxyerythronolide B to erythronolide B; uncurated glycosylation and deoxysugar steps between erythronolide B and erythromycin D are intentionally omitted.

Step 20: EryK hydroxylates erythromycin D to erythromycin C. The erythromycin B branch is excluded here because EryK does not accept erythromycin B efficiently.

Step 30: EryG methylates erythromycin C(1+) at the mycarosyl 3-O position to produce erythromycin A(1+) in RHEA:32647; this NaturalProductRecord remains grounded to neutral erythromycin A, CHEBI:42355.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 2 producers (1 causal) 14 cited occurrences BIOSYNTHETIC LOCUS 2 gene clusters 3 curated pathway steps NATURAL PRODUCT erythromycin A CHEBI:42355 Polyketides TARGETS & BIOACTIVITY 0 molecular targets 25 bioactivities · 1 graph

Causal graph — biosynthesis 8 nodes, 6 edges

Partial Saccharopolyspora erythraea NRRL 2338 erythromycin A biosynthesis graph for three curated tailoring enzymes.

SubjectPredicateObjectNotesEvidence
6-deoxyerythronolide B is hydroxylated by EryF
DOI:10.1128/jb.174.3.725-735.1992
  • reference
    DOI:10.1128/jb.174.3.725-735.1992
    evidence type
    PRIMARY_EXPERIMENT
    notes
    EryF catalyzes RHEA:40299.
EryF forms erythronolide B The full DEBS-to-glycosylated-macrolide route between erythronolide B and erythromycin D remains uncurated in this partial graph.
DOI:10.1128/jb.174.3.725-735.1992
  • reference
    DOI:10.1128/jb.174.3.725-735.1992
    evidence type
    PRIMARY_EXPERIMENT
    notes
    EryF catalyzes RHEA:40299.
erythromycin D is hydroxylated by EryK
DOI:10.1021/bi00006a006
  • reference
    DOI:10.1021/bi00006a006
    evidence type
    PRIMARY_EXPERIMENT
    notes
    EryK catalyzes RHEA:32631.
EryK forms erythromycin C
DOI:10.1021/bi00006a006
  • reference
    DOI:10.1021/bi00006a006
    evidence type
    PRIMARY_EXPERIMENT
    notes
    EryK catalyzes RHEA:32631.
erythromycin C is O-methylated by EryG
DOI:10.1128/jb.172.5.2541-2546.1990
  • reference
    DOI:10.1128/jb.172.5.2541-2546.1990
    evidence type
    PRIMARY_EXPERIMENT
    notes
    EryG catalyzes RHEA:32647.
EryG forms erythromycin A(1+)
DOI:10.1128/jb.172.5.2541-2546.1990
  • reference
    DOI:10.1128/jb.172.5.2541-2546.1990
    evidence type
    PRIMARY_EXPERIMENT
    notes
    EryG catalyzes RHEA:32647, whose ChEBI participants are the pH 7.3 erythromycin cations.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

AssayResultTarget enzymeSource detail
A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells.OTHER 1.636 uM; NOT_DETERMINEDNot recorded
pubchem.aid:624297
assay
A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells.
evidence
  • reference
    pubchem.aid:624297
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624297, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_056979 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
1.636
units
uM
Confirmatory fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compoundsOTHER 0.9698 uM; INACTIVENot recorded
pubchem.aid:1845226
assay
Confirmatory fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds
evidence
  • reference
    pubchem.aid:1845226
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1845226, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
INACTIVE
measurement type
OTHER
value
0.9698
units
uM
Cytochrome P450 Family 3 Subfamily A Member 4 (CYP3A4) small molecule antagonists: luciferase reporter qHTS assayOTHER 3.4528 uM; ACTIVENot recorded
pubchem.aid:1671201
assay
Cytochrome P450 Family 3 Subfamily A Member 4 (CYP3A4) small molecule antagonists: luciferase reporter qHTS assay
evidence
  • reference
    pubchem.aid:1671201
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1671201, deposited by 824; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
3.4528
units
uM
Cytochrome P450 Family 3 Subfamily A Member 4 (CYP3A4) small molecule antagonists: luciferase reporter qHTS assayOTHER 3.4528 uM; ACTIVENot recorded
pubchem.aid:1671201
assay
Cytochrome P450 Family 3 Subfamily A Member 4 (CYP3A4) small molecule antagonists: luciferase reporter qHTS assay
evidence
  • reference
    pubchem.aid:1671201
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1671201, deposited by 824; assay type Confirmatory. Source endpoint: Potency. Target accession ABI96208 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
3.4528
units
uM
Dopamine D2 receptor (DRD2) small molecule antagonists, cell-based qHTS assayOTHER 52.8704 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1963595
assay
Dopamine D2 receptor (DRD2) small molecule antagonists, cell-based qHTS assay
evidence
  • reference
    pubchem.aid:1963595
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963595, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
52.8704
units
uM
Dopamine D2 receptor (DRD2) small molecule antagonists, cell-based qHTS assayOTHER 52.8704 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1963595
assay
Dopamine D2 receptor (DRD2) small molecule antagonists, cell-based qHTS assay
evidence
  • reference
    pubchem.aid:1963595
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963595, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAH21195 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
52.8704
units
uM
Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assayIC50 80 uM; INACTIVENot recorded
pubchem.aid:652005
assay
Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay
evidence
  • reference
    pubchem.aid:652005
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 652005, deposited by Burnham Center for Chemical Genomics; assay type Confirmatory. Target accession NP_004291 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
INACTIVE
measurement type
IC50
value
80.0
units
uM
Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assayIC50 47.1 uM; INACTIVEUniProtKB:P24666
pubchem.aid:651700
assay
Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay
evidence
  • reference
    pubchem.aid:651700
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 651700, deposited by Burnham Center for Chemical Genomics; assay type Confirmatory.
call
INACTIVE
measurement type
IC50
value
47.1
units
uM
target enzyme
UniProtKB:P24666
Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTSOTHER 70.7946 uM; NOT_DETERMINEDNot recorded
pubchem.aid:504937
assay
Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS
evidence
  • reference
    pubchem.aid:504937
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 504937, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAA58377 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
70.7946
units
uM
Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A StreptococcusEC50 0.06 uM; ACTIVENot recorded
pubchem.aid:1900
assay
Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus
evidence
  • reference
    pubchem.aid:1900
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1900, deposited by Broad Institute; assay type Confirmatory.
call
ACTIVE
measurement type
EC50
value
0.06
units
uM
activity class
CYTOTOXIC
Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor ActivityEC50 0.06 uM; ACTIVENot recorded
pubchem.aid:1902
assay
Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity
evidence
  • reference
    pubchem.aid:1902
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1902, deposited by Broad Institute; assay type Confirmatory. Target accession NP_269944 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
EC50
value
0.06
units
uM
activity class
ENZYME_INHIBITOR
Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to StreptococcusEC50 0.06 uM; ACTIVENot recorded
pubchem.aid:1915
assay
Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus
evidence
  • reference
    pubchem.aid:1915
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1915, deposited by Broad Institute; assay type Confirmatory.
call
ACTIVE
measurement type
EC50
value
0.06
units
uM
activity class
CYTOTOXIC
Oatp1d1 Transport Assay from Article 10.1074/jbc.M113.518506: "Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide."KI 882 uM; INACTIVENot recorded
PMID:24126916
assay
Oatp1d1 Transport Assay from Article 10.1074/jbc.M113.518506: "Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide."
evidence
  • reference
    PMID:24126916
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1802450, deposited by BindingDB; assay type Confirmatory.
call
INACTIVE
measurement type
KI
value
882.0
units
uM
Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubationOTHER 9.285 uM; NOT_DETERMINEDNot recorded
pubchem.aid:504834
assay
Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation
evidence
  • reference
    pubchem.aid:504834
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 504834, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
9.285
units
uM
Surface Plasmon Resonance (SPR) from US Patent US20240118263: "TARGET FOR SCREENING ANTI-TUMOR DRUG, USE THEREOF AND SCREENING METHOD THEREFOR"KD 10.4 uM; INACTIVEUniProtKB:Q8IZQ5
pubchem.aid:1963645
assay
Surface Plasmon Resonance (SPR) from US Patent US20240118263: "TARGET FOR SCREENING ANTI-TUMOR DRUG, USE THEREOF AND SCREENING METHOD THEREFOR"
evidence
  • reference
    pubchem.aid:1963645
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963645, deposited by BindingDB; assay type Confirmatory.
call
INACTIVE
measurement type
KD
value
10.4
units
uM
target enzyme
UniProtKB:Q8IZQ5
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1)OTHER 125.892 uM; INACTIVENot recorded
pubchem.aid:1645883
assay
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1)
evidence
  • reference
    pubchem.aid:1645883
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645883, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
INACTIVE
measurement type
OTHER
value
125.892
units
uM
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1)OTHER 125.892 uM; INACTIVEUniProtKB:O95398
pubchem.aid:1645883
assay
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1)
evidence
  • reference
    pubchem.aid:1645883
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645883, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
INACTIVE
measurement type
OTHER
value
125.892
units
uM
target enzyme
UniProtKB:O95398
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2)OTHER 0.7943 uM; INACTIVENot recorded
pubchem.aid:1645887
assay
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2)
evidence
  • reference
    pubchem.aid:1645887
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645887, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
INACTIVE
measurement type
OTHER
value
0.7943
units
uM
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2)OTHER 0.7943 uM; INACTIVEUniProtKB:Q8WZA2
pubchem.aid:1645887
assay
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2)
evidence
  • reference
    pubchem.aid:1645887
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645887, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
INACTIVE
measurement type
OTHER
value
0.7943
units
uM
target enzyme
UniProtKB:Q8WZA2
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cellsOTHER 0.0006 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1963824
assay
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells
evidence
  • reference
    pubchem.aid:1963824
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963824, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
0.0006
units
uM
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cellsOTHER 0.0006 uM; NOT_DETERMINEDUniProtKB:P43405
pubchem.aid:1963824
assay
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells
evidence
  • reference
    pubchem.aid:1963824
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963824, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
0.0006
units
uM
target enzyme
UniProtKB:P43405
qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent)OTHER 1.9953 uM; NOT_DETERMINEDNot recorded
pubchem.aid:485294
assay
qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent)
evidence
  • reference
    pubchem.aid:485294
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 485294, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession 2HDS_A was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
1.9953
units
uM
qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent)OTHER 39.8107 uM; INACTIVENot recorded
pubchem.aid:485341
assay
qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent)
evidence
  • reference
    pubchem.aid:485341
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 485341, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession 2HDS_A was left ungrounded because PubChem did not provide a UniProtKB accession.
call
INACTIVE
measurement type
OTHER
value
39.8107
units
uM
qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screenOTHER 16.865 uM; NOT_DETERMINEDNot recorded
pubchem.aid:743209
assay
qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen
evidence
  • reference
    pubchem.aid:743209
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 743209, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
16.865
units
uM
qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screenOTHER 52.8704 uM; NOT_DETERMINEDNot recorded
pubchem.aid:743203
assay
qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen
evidence
  • reference
    pubchem.aid:743203
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 743203, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
52.8704
units
uM
notes
46 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.

Elsewhere in the fleet

Explore across X-Mech

AntibioticMech (erythromycin A) ↗ MediaIngredientMech (CHEBI:42355) ↗ TaxonMech: Saccharopolyspora erythraea NRRL 2338 (NCBITaxon:405948) ↗ TaxonMech: Aeromicrobium erythreum (NCBITaxon:2041) ↗ PathwayMech (mibig:BGC0000055) ↗ PathwayMech (mibig:BGC0000054) ↗

Open questions 1

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000054, BGC0000055. Confirm they describe the same compound rather than an upstream cross-reference error.

Provenance

Source conceptSourceVersion
BGC0000055MIBIG5
BGC0000054MIBIG5
CHEBI:42355CHEBI3-star

This page is generated from data/natural_products/polyketides/erythromycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.