mevinic acid

CHEBI:39508 EXACT SEEDED cytotoxicenzyme inhibitor

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A member of the class of hexahydronaphthalenes that is 1,2,6,7,8,8a-hexahydronaphthalene which is substituted by a (3R,5R)-6-carboxy-3,5-dihydroxyhexyl group at position 1, a methyl group at position 2, and a (2S)-2-methylbutanoyloxy group at position 8 (the 1S,2S,8S,8aR isomer). Lactonisation of the hydroxy-carboxylic acid chain at position 1 affords mevastatin.

Structure

Standard InChIKey	BOZILQFLQYBIIY-INTXDZFKSA-N
SMILES	CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@@H]12
Stereochemistry	fully defined
Cross-references	npatlas:NPA018102, pubchem:64715

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Penicillium citrinum NCBITaxon:5077	SOURCE_ASSERTION	mibig:BGC0000039	PMID:12172803

Occurrences 3

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Penicillium javanicum NCBITaxon:28578	LOTUS	DOI:10.1021/NP040052S
Penicillium javanicum NCBITaxon:28578	LOTUS	DOI:10.1039/P19760001165
Penicillium citrinum NCBITaxon:5077	LOTUS	DOI:10.1007/S00438-002-0697-Y

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000039	Penicillium citrinum NCBITaxon:5077	CLUSTER_UNSTATED	genbank:AB072893.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Explore across X-Mech

AntibioticMech (mevinic acid) ↗ MediaIngredientMech (CHEBI:39508) ↗ TaxonMech: Penicillium citrinum (NCBITaxon:5077) ↗ PathwayMech (mibig:BGC0000039) ↗

Open questions 1

name-disagreement — ChEBI calls this structure 'mevinic acid' and MIBiG calls it 'compactin'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.

Provenance

Source concept	Source	Version
BGC0000039	MIBIG	3
CHEBI:39508	CHEBI	3-star

This page is generated from data/natural_products/polyketides/mevinic-acid.yaml, which is generated from the committed inventories. Neither is edited by hand.

Assay	Result	Target enzyme	Source detail
A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression	OTHER 12.5893 uM; NOT_DETERMINED	Not recorded	pubchem.aid:624263 assay A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression evidence reference pubchem.aid:624263 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 624263, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAQ89316 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 12.5893 units uM
A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression	OTHER 12.5893 uM; NOT_DETERMINED	Not recorded	pubchem.aid:624263 assay A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression evidence reference pubchem.aid:624263 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 624263, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession BAA25751 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 12.5893 units uM
A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells.	OTHER 7.3078 uM; INACTIVE	Not recorded	pubchem.aid:624296 assay A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. evidence reference pubchem.aid:624296 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 624296, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_056979 was left ungrounded because PubChem did not provide a UniProtKB accession. call INACTIVE measurement type OTHER value 7.3078 units uM
A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells.	OTHER 3.2643 uM; NOT_DETERMINED	Not recorded	pubchem.aid:624297 assay A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. evidence reference pubchem.aid:624297 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 624297, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_056979 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 3.2643 units uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: AML-191 cell line	OTHER 10.4837 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2202236 assay BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: AML-191 cell line evidence reference pubchem.aid:2202236 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202236, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 10.4837 units uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: AML-194 cell line	OTHER 18.6429 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2202237 assay BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: AML-194 cell line evidence reference pubchem.aid:2202237 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202237, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 18.6429 units uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: HNT-34 cell line	OTHER 18.6429 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2202234 assay BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: HNT-34 cell line evidence reference pubchem.aid:2202234 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202234, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 18.6429 units uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: MV-4-11 cell line	OTHER 18.6429 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2202233 assay BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: MV-4-11 cell line evidence reference pubchem.aid:2202233 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202233, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 18.6429 units uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: OCI-AML3 cell line	OTHER 11.7629 uM; ACTIVE	Not recorded	pubchem.aid:2202232 assay BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: OCI-AML3 cell line evidence reference pubchem.aid:2202232 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202232, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 11.7629 units uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: SET-2 cell line	OTHER 20.9177 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2202231 assay BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: SET-2 cell line evidence reference pubchem.aid:2202231 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202231, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 20.9177 units uM
BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: UCSD-AML1 cell line	OTHER 14.8086 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2202235 assay BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML: UCSD-AML1 cell line evidence reference pubchem.aid:2202235 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202235, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 14.8086 units uM
Cell Viability qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome	OTHER 12.5893 uM; NOT_DETERMINED	Not recorded	PMID:33910017 assay Cell Viability qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome evidence reference PMID:33910017 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1508629, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 12.5893 units uM
Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R	OTHER 17.7828 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1963990 assay Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R evidence reference pubchem.aid:1963990 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1963990, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 17.7828 units uM
Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line 8505C	OTHER 4.9071 uM; ACTIVE	Not recorded	pubchem.aid:2202553 assay Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line 8505C evidence reference pubchem.aid:2202553 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202553, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 4.9071 units uM activity class CYTOTOXIC
Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line THJ-11T	OTHER 9.791 uM; ACTIVE	Not recorded	pubchem.aid:2202552 assay Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line THJ-11T evidence reference pubchem.aid:2202552 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202552, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 9.791 units uM activity class CYTOTOXIC
Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line THJ-16T	OTHER 9.791 uM; ACTIVE	Not recorded	pubchem.aid:2202551 assay Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line THJ-16T evidence reference pubchem.aid:2202551 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202551, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 9.791 units uM activity class CYTOTOXIC
Confirmatory qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	OTHER 7.9433 uM; NOT_DETERMINED	Not recorded	PMID:33910017 assay Confirmatory qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay evidence reference PMID:33910017 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1508628, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 7.9433 units uM
Confirmatory qHTS to identify inhibitors of SARS-CoV-2 cell entry	OTHER 1.9182 uM; INACTIVE	Not recorded	pubchem.aid:1645844 assay Confirmatory qHTS to identify inhibitors of SARS-CoV-2 cell entry evidence reference pubchem.aid:1645844 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645844, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call INACTIVE measurement type OTHER value 1.9182 units uM
Counterscreen for inhibitors of NLG for Luciferase Activators Measured in Cell-Based System Using Plate Reader - 2146-03_Inhibitor_Dose_CherryPick_Activity	OTHER 1.26 uM; ACTIVE	Not recorded	pubchem.aid:624404 assay Counterscreen for inhibitors of NLG for Luciferase Activators Measured in Cell-Based System Using Plate Reader - 2146-03_Inhibitor_Dose_CherryPick_Activity evidence reference pubchem.aid:624404 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 624404, deposited by Broad Institute; assay type Confirmatory. Source endpoint: AbsAC35_uM. call ACTIVE measurement type OTHER value 1.26 units uM activity class ENZYME_INHIBITOR
Counterscreen qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: GLuc-NoTag assay	OTHER 50.1187 uM; NOT_DETERMINED	Not recorded	PMID:33910017 assay Counterscreen qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: GLuc-NoTag assay evidence reference PMID:33910017 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1508627, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 50.1187 units uM
Cytometry Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF cells	OTHER 9.2683 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2668 assay Cytometry Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF cells evidence reference pubchem.aid:2668 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2668, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_004949 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 9.2683 units uM
HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators	OTHER 4.1092 uM; NOT_DETERMINED	Not recorded	pubchem.aid:488982 assay HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators evidence reference pubchem.aid:488982 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 488982, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_000785 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 4.1092 units uM
High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF Cells	OTHER 16.4816 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2667 assay High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF Cells evidence reference pubchem.aid:2667 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2667, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_004949 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 16.4816 units uM
Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_Dose_CherryPick_Activity	OTHER 0.18 uM; ACTIVE	Not recorded	pubchem.aid:624491 assay Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_Dose_CherryPick_Activity evidence reference pubchem.aid:624491 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 624491, deposited by Broad Institute; assay type Confirmatory. Source endpoint: AbsAC26_uM. call ACTIVE measurement type OTHER value 0.18 units uM activity class ENZYME_INHIBITOR
Nrf2 qHTS screen for inhibitors	OTHER 18.3564 uM; NOT_DETERMINED	Not recorded	pubchem.aid:504444 assay Nrf2 qHTS screen for inhibitors evidence reference pubchem.aid:504444 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504444, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001138884 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 18.3564 units uM notes 115 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.