NaturalProductMech

Browse · Polyketides · oligomycin

oligomycin

naturalproductmech:mibig-86258f37c8 MINTED SEEDED enzyme inhibitor

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyMNULEGDCPYONBU-WMBHJXFZSA-N
SMILESCC[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
Stereochemistryfully defined
Cross-referencespubchem:5281899

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Streptomyces avermitilis
NCBITaxon:33903		 SOURCE_ASSERTION mibig:BGC0000117 PMID:11572948

Occurrences 25

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.1002/CBDV.201700140
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.1007/S00253-008-1684-Y
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.1007/S00438-009-0502-2
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.1007/S12223-010-0002-0
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.1016/J.MYCMED.2017.10.007
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.1038/S41429-019-0239-Z
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.1099/MIC.0.048371-0
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.1111/J.1574-6968.2009.01721.X
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.1128/JB.00017-11
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.1128/MRA.01531-18
Streptomyces xinghaiensis
NCBITaxon:1038928		 LOTUS DOI:10.14348/MOLCELLS.2016.2226
Streptomyces
NCBITaxon:1883		 LOTUS DOI:10.1016/S0040-4039(00)84680-8
Streptomyces
NCBITaxon:1883		 LOTUS DOI:10.7164/ANTIBIOTICS.40.1053
Streptomyces
NCBITaxon:1883		 LOTUS DOI:10.7164/ANTIBIOTICS.46.1334
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1002/CBDV.201700140
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00253-008-1684-Y
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00438-009-0502-2
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S12223-010-0002-0
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1016/J.MYCMED.2017.10.007
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1038/S41429-019-0239-Z
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1099/MIC.0.048371-0
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1111/J.1574-6968.2009.01721.X
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1128/JB.00017-11
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1128/MRA.01531-18
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.14348/MOLCELLS.2016.2226

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000117 Streptomyces avermitilis
NCBITaxon:33903 		CLUSTER_UNSTATED genbank:AB070940.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 25 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT oligomycin naturalproductmech:mibig-86258f37c8 Polyketides TARGETS & BIOACTIVITY 0 molecular targets 18 bioactivities · 0 graphs

Bioactivities 18

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

AssayResultTarget enzymeSource detail
HTS assay for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit ConfirmationOTHER 7.0584 uM; ACTIVENot recorded
pubchem.aid:624248
assay
HTS assay for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation
evidence
  • reference
    pubchem.aid:624248
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624248, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession AAH15051 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
7.0584
units
uM
Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTSOTHER 33.5875 uM; NOT_DETERMINEDNot recorded
pubchem.aid:504845
assay
Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS
evidence
  • reference
    pubchem.aid:504845
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 504845, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession ABC94591 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
33.5875
units
uM
Inhibitors of the vitamin D receptor (VDR): qHTSOTHER 56.2341 uM; NOT_DETERMINEDNot recorded
pubchem.aid:504847
assay
Inhibitors of the vitamin D receptor (VDR): qHTS
evidence
  • reference
    pubchem.aid:504847
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 504847, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001017535 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
56.2341
units
uM
Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2OTHER 44.6684 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1479
assay
Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2
evidence
  • reference
    pubchem.aid:1479
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1479, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001121649 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
44.6684
units
uM
qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid LeukemiaOTHER 39.8107 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1477
assay
qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia
evidence
  • reference
    pubchem.aid:1477
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1477, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
39.8107
units
uM
qHTS Assay for Enhancers of SMN2 Splice Variant ExpressionOTHER 0.01 uM; INACTIVENot recorded
pubchem.aid:1458
assay
qHTS Assay for Enhancers of SMN2 Splice Variant Expression
evidence
  • reference
    pubchem.aid:1458
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1458, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_059107 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
INACTIVE
measurement type
OTHER
value
0.01
units
uM
qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1)OTHER 19.9526 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1030
assay
qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1)
evidence
  • reference
    pubchem.aid:1030
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1030, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAP35567 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
19.9526
units
uM
qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase)OTHER 0.0006 uM; ACTIVENot recorded
pubchem.aid:1490
assay
qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase)
evidence
  • reference
    pubchem.aid:1490
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1490, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession AAG24257 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
0.0006
units
uM
activity class
ENZYME_INHIBITOR
qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T BindingOTHER 17.7828 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1460
assay
qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding
evidence
  • reference
    pubchem.aid:1460
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1460, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAI14949 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
17.7828
units
uM
qHTS for Inhibitors of binding or entry into cells for Lassa VirusOTHER 39.8107 uM; ACTIVENot recorded
pubchem.aid:720533
assay
qHTS for Inhibitors of binding or entry into cells for Lassa Virus
evidence
  • reference
    pubchem.aid:720533
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 720533, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
39.8107
units
uM
activity class
ENZYME_INHIBITOR
qHTS for Inhibitors of binding or entry into cells for Marburg VirusOTHER 10 uM; ACTIVENot recorded
pubchem.aid:720532
assay
qHTS for Inhibitors of binding or entry into cells for Marburg Virus
evidence
  • reference
    pubchem.aid:720532
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 720532, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession B45705 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
10.0
units
uM
activity class
ENZYME_INHIBITOR
qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2OTHER 39.8107 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1469
assay
qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2
evidence
  • reference
    pubchem.aid:1469
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1469, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001121649 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
39.8107
units
uM
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation using MMS Stimulated ELG1OTHER 0.0112 uM; ACTIVENot recorded
pubchem.aid:624249
assay
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation using MMS Stimulated ELG1
evidence
  • reference
    pubchem.aid:624249
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624249, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession AAH15051 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
0.0112
units
uM
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation in Cell-Based Luciferin AssayOTHER 0.0315 uM; NOT_DETERMINEDNot recorded
pubchem.aid:624247
assay
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation in Cell-Based Luciferin Assay
evidence
  • reference
    pubchem.aid:624247
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624247, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAH15051 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
0.0315
units
uM
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with 5FU ViabilityOTHER 35.3758 uM; NOT_DETERMINEDNot recorded
pubchem.aid:624250
assay
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with 5FU Viability
evidence
  • reference
    pubchem.aid:624250
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624250, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAH15051 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
35.3758
units
uM
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with MMS ViabilityOTHER 0.0112 uM; ACTIVENot recorded
pubchem.aid:624251
assay
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with MMS Viability
evidence
  • reference
    pubchem.aid:624251
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624251, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession AAH15051 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
0.0112
units
uM
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with Unstimulated Viability AssayOTHER 0.0281 uM; ACTIVENot recorded
pubchem.aid:624252
assay
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with Unstimulated Viability Assay
evidence
  • reference
    pubchem.aid:624252
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624252, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession AAH15051 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
0.0281
units
uM
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: SAR in Cell-Based Luciferin Counter AssayOTHER 0.0315 uM; NOT_DETERMINEDNot recorded
pubchem.aid:686934
assay
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: SAR in Cell-Based Luciferin Counter Assay
evidence
  • reference
    pubchem.aid:686934
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 686934, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAH15051 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
0.0315
units
uM

Explore across X-Mech

AntibioticMech (oligomycin) ↗ MediaIngredientMech (naturalproductmech:mibig-86258f37c8) ↗ TaxonMech: Streptomyces avermitilis (NCBITaxon:33903) ↗ PathwayMech (mibig:BGC0000117) ↗

Provenance

Source conceptSourceVersion
BGC0000117MIBIG5

This page is generated from data/natural_products/polyketides/oligomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.