resistomycin

naturalproductmech:mibig-14d7cc15c5 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	ABLACSIRCKEUOB-UHFFFAOYSA-N
SMILES	CC1=CC(=C2C3=C4C(=CC(=C13)O)C(C(=O)C5=C(C=C(C(=C45)C2=O)O)O)(C)C)O
Stereochemistry	fully defined
Cross-references	pubchem:5282060

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces resistomycificus NCBITaxon:67356	SOURCE_ASSERTION	mibig:BGC0000264	PMID:14982421

Occurrences 16

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces NCBITaxon:1883	LOTUS	DOI:10.1002/CHIN.200412276
Streptomyces corchorusii NCBITaxon:1903	LOTUS	DOI:10.1134/S1068162006030125
Streptomyces olivaceoviridis NCBITaxon:1921	LOTUS	DOI:10.1134/S1068162006030125
Streptomyces vinaceus NCBITaxon:1960	LOTUS	DOI:10.1002/JLAC.198319830509
Streptomyces griseoincarnatus NCBITaxon:29305	LOTUS	DOI:10.7164/ANTIBIOTICS.38.113
Streptomyces griseoflavus NCBITaxon:35619	LOTUS	DOI:10.1002/JLAC.198319830509
Streptomyces aurantiacus NCBITaxon:47760	LOTUS	DOI:10.1007/S12275-011-1260-5
Streptomyces aurantiacus NCBITaxon:47760	LOTUS	DOI:10.1016/J.SAA.2011.12.072
Streptomyces canus NCBITaxon:58343	LOTUS	DOI:10.1021/JF305210U
Streptomyces variabilis NCBITaxon:67372	LOTUS	DOI:10.7164/ANTIBIOTICS.38.113
Streptomyces resistomycificus NCBITaxon:67356	LOTUS	DOI:10.1002/JLAC.198319830509
Streptomyces resistomycificus NCBITaxon:67356	LOTUS	DOI:10.1007/S13205-018-1304-1
Streptomyces resistomycificus NCBITaxon:67356	LOTUS	DOI:10.1016/J.FEBSLET.2009.07.061
Streptomyces resistomycificus NCBITaxon:67356	LOTUS	DOI:10.1016/J.SAA.2011.12.072
Streptomyces resistomycificus NCBITaxon:67356	LOTUS	DOI:10.1021/JA0390698
Streptomyces resistomycificus NCBITaxon:67356	LOTUS	DOI:10.1021/JO01284A072

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000264	Streptomyces resistomycificus NCBITaxon:67356	CLUSTER_DEMONSTRATED	genbank:AJ585192.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Explore across X-Mech

AntibioticMech (resistomycin) ↗ MediaIngredientMech (naturalproductmech:mibig-14d7cc15c5) ↗ TaxonMech: Streptomyces resistomycificus (NCBITaxon:67356) ↗ PathwayMech (mibig:BGC0000264) ↗

Provenance

Source concept	Source	Version
BGC0000264	MIBIG	5

This page is generated from data/natural_products/polyketides/resistomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.