ustilaginoidin F
naturalproductmech:mibig-fc5f32e530 MINTED SEEDED antiviralcytotoxicenzyme inhibitor
Structure
| Standard InChIKey | JGQBYBXYRUCBQY-UHFFFAOYSA-N |
|---|---|
| SMILES | CC1CC(=O)C2=C(O1)C=C3C(=C2O)C(=CC(=C3C4=C(C=C(C5=C(C6=C(C=C54)OC(CC6=O)C)O)O)O)O)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:160115, chembl:CHEMBL463175 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Ustilaginoidea virens NCBITaxon:1159556 |
BGC_CHARACTERIZED | mibig:BGC0002177 | PMID:30807673 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Verticillium NCBITaxon:1036719 |
LOTUS | DOI:10.7164/ANTIBIOTICS.28.602 |
| Plenodomus influorescens NCBITaxon:1077371 |
LOTUS | DOI:10.3390/MD18020073 |
| Pyrenochaeta nobilis NCBITaxon:390895 |
LOTUS | DOI:10.3390/MD18020073 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002177 | Ustilaginoidea virens NCBITaxon:1159556 |
CLUSTER_DEMONSTRATED | genbank:JHTR01000008.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 25
| Assay | Result | Reference |
|---|---|---|
| A TR-FRET Counter Screen assay to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G | IC50 100 uM | pubchem.aid:1117362 |
| A cell based assay for assessing THP-1 cell cytotoxicity of Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G | 3.08 uM | pubchem.aid:1117359 |
| A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi | IC50 28.55 uM | pubchem.aid:2384 |
| A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen | EC50 0.1 uM | pubchem.aid:2252 |
| A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. | 12.9953 uM | pubchem.aid:624296 |
| A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. | 6.5131 uM | pubchem.aid:624297 |
| A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen | IC50 26.958 uM | pubchem.aid:1985 |
| A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi | IC50 27.33 uM | pubchem.aid:1850 |
| ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick | EC50 5.102 uM | pubchem.aid:463229 |
| Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression | EC50 150 uM | pubchem.aid:1914 |
| An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G | IC50 7.618 uM | pubchem.aid:1117361 |
| Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) | 19.9526 uM | pubchem.aid:2572 |
| Counterscreen for APE1 Inhibitors: Confirmatory Fluorescent Dye Displacement Assay | 4.4668 uM | pubchem.aid:2741 |
| Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Assay | 4.4668 uM | pubchem.aid:2564 |
| Counterscreen for APE1 Inhibitors: qHTS Assay for Inhibitors of Endonuclease IV | 10 uM | pubchem.aid:2565 |
| Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization | 1.122 uM | pubchem.aid:1463 |
| Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors | IC50 1.4919 uM | pubchem.aid:1417 |
| Dose Response concentration confirmation of uHTS hits from a small molecule activators of mouse intestinal alkaline phosphatase via a luminescent assay | EC50 19.1 uM | pubchem.aid:488783 |
| Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Human Intestinal Alkaline Phosphatase | EC50 21.7 uM | pubchem.aid:488873 |
| Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase | EC50 21.1 uM | pubchem.aid:488878 |
| Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. | EC50 26.7 uM | pubchem.aid:488880 |
| Dose response biochemical high throughput screening assay for inhibitors of the p97 ATPase | IC50 43.86 uM | pubchem.aid:1534 |
| Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation | EC50 2.499 uM | pubchem.aid:434968 |
| Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity | EC50 1.57 uM | pubchem.aid:435010 |
| Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity | EC50 1.781 uM | pubchem.aid:449749 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002177 | MIBIG | 2 |
This page is generated from data/natural_products/polyketides/ustilaginoidin-f.yaml, which is generated from the committed inventories. Neither is edited by hand.