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(-)-Mellein

naturalproductmech:mibig-5879a27c10 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyKWILGNNWGSNMPA-ZCFIWIBFSA-N
SMILESC[C@@H]1CC2=C(C(=CC=C2)O)C(=O)O1
Stereochemistryfully defined
Cross-referencespubchem:114679

Filing pathway

Shikimates and phenylpropanoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Parastagonospora nodorum
NCBITaxon:13684		 SOURCE_ASSERTION mibig:BGC0001244 PMID:25326302

Occurrences 23

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Microsphaeropsis
NCBITaxon:107453		 LOTUS DOI:10.1021/NP980341E
Pezicula livida
NCBITaxon:108568		 LOTUS DOI:10.7164/ANTIBIOTICS.47.113
Ficus formosana
NCBITaxon:1127366		 LOTUS DOI:10.1055/S-2005-873163
Aspergillus melleus
NCBITaxon:138277		 LOTUS DOI:10.1038/165274A0
Aspergillus melleus
NCBITaxon:138277		 LOTUS DOI:10.1039/P19840001021
Aspergillus melleus
NCBITaxon:138277		 LOTUS DOI:10.1271/BBB.60.1375
Mycetinis alliaceus
NCBITaxon:139086		 LOTUS DOI:10.1039/P19810001790
Plenodomus tracheiphilus
NCBITaxon:1408161		 LOTUS DOI:10.1016/0031-9422(93)85221-C
Millettia leucantha
NCBITaxon:1712206		 LOTUS DOI:10.1007/S12272-011-0603-4
Garcinia bancana
NCBITaxon:180102		 LOTUS DOI:10.1002/CHIN.200537209
Enicosanthum membranifolium
NCBITaxon:235726		 LOTUS DOI:10.1002/CHIN.200738212
Enicosanthum membranifolium
NCBITaxon:235726		 LOTUS DOI:10.1016/J.BMC.2007.03.051
Parastagonospora nodorum
NCBITaxon:321614		 LOTUS DOI:10.1016/S0031-9422(00)82234-7
Parastagonospora nodorum
NCBITaxon:321614		 LOTUS DOI:10.1128/AEM.02745-14
Ficus subcuneata
NCBITaxon:326052		 LOTUS DOI:10.1055/S-2005-873163
Picea glauca
NCBITaxon:3330		 LOTUS DOI:10.1021/NP800192F
Millettia vatkei
NCBITaxon:3851323		 LOTUS DOI:10.1007/S12272-011-0603-4
Lasiodiplodia theobromae
NCBITaxon:45133		 LOTUS DOI:10.1016/J.TET.2009.10.084
Lasiodiplodia theobromae
NCBITaxon:45133		 LOTUS DOI:10.1016/S0031-9422(00)90622-8
Garcinia mangostana
NCBITaxon:58228		 LOTUS DOI:10.1016/J.PHYTOL.2012.11.007
Coniothyrium
NCBITaxon:78388		 LOTUS DOI:10.1021/NP980341E
Ipomoea pes-caprae
NCBITaxon:89656		 LOTUS DOI:10.1002/PTR.2650060211
Ipomoea pes-caprae
NCBITaxon:89656		 LOTUS DOI:10.1055/S-2006-960196

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0001244 Parastagonospora nodorum
NCBITaxon:13684 		CLUSTER_UNSTATED genbank:KM365454.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 23 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT (-)-Mellein naturalproductmech:mibig-5879a27c10 Shikimates and phenylpropanoids TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 0 graphs

Explore across X-Mech

AntibioticMech ((-)-Mellein) ↗ MediaIngredientMech (naturalproductmech:mibig-5879a27c10) ↗ TaxonMech: Parastagonospora nodorum (NCBITaxon:13684) ↗ PathwayMech (mibig:BGC0001244) ↗

Provenance

Source conceptSourceVersion
BGC0001244MIBIG3

This page is generated from data/natural_products/shikimates_and_phenylpropanoids/mellein.yaml, which is generated from the committed inventories. Neither is edited by hand.