beauvericin
naturalproductmech:mibig-4c106eac10 MINTED SEEDED cytotoxicenzyme inhibitor
Structure
| Standard InChIKey | GYSCAQFHASJXRS-UHFFFAOYSA-N |
|---|---|
| SMILES | CC(C)C1OC(=O)C(CC2=CC=CC=C2)N(C)C(=O)C(OC(=O)C(CC2=CC=CC=C2)N(C)C(=O)C(OC(=O)C(CC2=CC=CC=C2)N(C)C1=O)C(C)C)C(C)C |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:3007984, npatlas:NPA01888 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Beauveria bassiana NCBITaxon:176275 |
SOURCE_ASSERTION | mibig:BGC0000313 | DOI:10.1016/s0040-4039(01)88668-8 |
Occurrences 16
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Fusarium avenaceum NCBITaxon:40199 |
LOTUS | DOI:10.1007/BF03192255 |
| Fusarium avenaceum NCBITaxon:40199 |
LOTUS | DOI:10.1007/S11427-013-4505-1 |
| Fusarium avenaceum NCBITaxon:40199 |
LOTUS | DOI:10.1021/NP060394T |
| Fusarium avenaceum NCBITaxon:40199 |
LOTUS | DOI:10.1590/S0102-695X2012005000106 |
| Paecilomyces tenuipes NCBITaxon:45847 |
LOTUS | DOI:10.1016/S0040-4020(02)00294-6 |
| Fusarium oxysporum NCBITaxon:5507 |
LOTUS | DOI:10.1007/BF03192255 |
| Fusarium oxysporum NCBITaxon:5507 |
LOTUS | DOI:10.1007/S11427-013-4505-1 |
| Fusarium oxysporum NCBITaxon:5507 |
LOTUS | DOI:10.1016/J.FM.2014.09.009 |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1007/BF03192255 |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1007/S11427-013-4505-1 |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1021/NP060394T |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1590/S0102-695X2012005000106 |
| Fusarium equiseti NCBITaxon:61235 |
LOTUS | DOI:10.1007/BF03192255 |
| Fusarium equiseti NCBITaxon:61235 |
LOTUS | DOI:10.1007/S11427-013-4505-1 |
| Fusarium equiseti NCBITaxon:61235 |
LOTUS | DOI:10.1021/NP060394T |
| Fusarium equiseti NCBITaxon:61235 |
LOTUS | DOI:10.1590/S0102-695X2012005000106 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000313 | Beauveria bassiana NCBITaxon:176275 |
CLUSTER_UNSTATED | genbank:EU886196.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 22
| Assay | Result | Reference |
|---|---|---|
| Constitutive androstane receptor (CAR) small molecule agonists, cell-based qHTS assay in HepG2 cells | 6.108 uM | pubchem.aid:2202728 |
| Constitutive androstane receptor (CAR) small molecule agonists, cell-based qHTS assay in HepG2 cells | 6.108 uM | pubchem.aid:2202728 |
| GF-AFC viability counterscreen for inhibitors of alpha-synuclein gene (SNCA) expression | 0.63 uM | pubchem.aid:1671193 |
| P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 4.8499 uM | PMID:31515284 |
| Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds. | 1.7756 uM | pubchem.aid:1845221 |
| Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1) | 0.7592 uM | pubchem.aid:1845191 |
| Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1) | 0.7592 uM | pubchem.aid:1845191 |
| Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C) | 4.826 uM | pubchem.aid:1645877 |
| Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C) | 4.826 uM | pubchem.aid:1645877 |
| Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B) | 6.8169 uM | pubchem.aid:1645876 |
| Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B) | 6.8169 uM | pubchem.aid:1645876 |
| Primary qHTS for small molecule compounds that upregulate eGFP-tagged delta133p53alpha (in N-terminal) cells. | 3.1575 uM | pubchem.aid:2060322 |
| Primary qHTS for small molecule compounds that upregulate eGFP-tagged delta133p53alpha (in N-terminal) cells. | 3.1575 uM | pubchem.aid:2060322 |
| Primary qHTS to identify anti-liver cancer compounds using libraries of approved drugs and bioactive compounds | 1.9953 uM | pubchem.aid:2202548 |
| Primary redox qHTS assay for identification of artifact compounds. | 6.3 uM | pubchem.aid:1845223 |
| Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells | 5.4417 uM | pubchem.aid:1963824 |
| Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells | 5.4417 uM | pubchem.aid:1963824 |
| Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 cells | 3.8524 uM | pubchem.aid:1963823 |
| Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 cells | 3.8524 uM | pubchem.aid:1963823 |
| Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | ACTIVE | PMID:31498718 |
| Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approved drugs and bioactive compounds | ACTIVE | pubchem.aid:1345084 |
| qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma treatment | ACTIVE | pubchem.aid:1296009 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000313 | MIBIG | 4 |
This page is generated from data/natural_products/unclassified/beauvericin.yaml, which is generated from the committed inventories. Neither is edited by hand.