NaturalProductMech

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beauvericin

naturalproductmech:mibig-4c106eac10 MINTED SEEDED cytotoxicenzyme inhibitor

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyGYSCAQFHASJXRS-UHFFFAOYSA-N
SMILESCC(C)C1OC(=O)C(CC2=CC=CC=C2)N(C)C(=O)C(OC(=O)C(CC2=CC=CC=C2)N(C)C(=O)C(OC(=O)C(CC2=CC=CC=C2)N(C)C1=O)C(C)C)C(C)C
Stereochemistry undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-referencespubchem:3007984, npatlas:NPA01888

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Beauveria bassiana
NCBITaxon:176275		 SOURCE_ASSERTION mibig:BGC0000313 DOI:10.1016/s0040-4039(01)88668-8

Occurrences 16

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Fusarium avenaceum
NCBITaxon:40199		 LOTUS DOI:10.1007/BF03192255
Fusarium avenaceum
NCBITaxon:40199		 LOTUS DOI:10.1007/S11427-013-4505-1
Fusarium avenaceum
NCBITaxon:40199		 LOTUS DOI:10.1021/NP060394T
Fusarium avenaceum
NCBITaxon:40199		 LOTUS DOI:10.1590/S0102-695X2012005000106
Paecilomyces tenuipes
NCBITaxon:45847		 LOTUS DOI:10.1016/S0040-4020(02)00294-6
Fusarium oxysporum
NCBITaxon:5507		 LOTUS DOI:10.1007/BF03192255
Fusarium oxysporum
NCBITaxon:5507		 LOTUS DOI:10.1007/S11427-013-4505-1
Fusarium oxysporum
NCBITaxon:5507		 LOTUS DOI:10.1016/J.FM.2014.09.009
Fusarium sporotrichioides
NCBITaxon:5514		 LOTUS DOI:10.1007/BF03192255
Fusarium sporotrichioides
NCBITaxon:5514		 LOTUS DOI:10.1007/S11427-013-4505-1
Fusarium sporotrichioides
NCBITaxon:5514		 LOTUS DOI:10.1021/NP060394T
Fusarium sporotrichioides
NCBITaxon:5514		 LOTUS DOI:10.1590/S0102-695X2012005000106
Fusarium equiseti
NCBITaxon:61235		 LOTUS DOI:10.1007/BF03192255
Fusarium equiseti
NCBITaxon:61235		 LOTUS DOI:10.1007/S11427-013-4505-1
Fusarium equiseti
NCBITaxon:61235		 LOTUS DOI:10.1021/NP060394T
Fusarium equiseti
NCBITaxon:61235		 LOTUS DOI:10.1590/S0102-695X2012005000106

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000313 Beauveria bassiana
NCBITaxon:176275 		CLUSTER_UNSTATED genbank:EU886196.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 16 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT beauvericin naturalproductmech:mibig-4c106eac10 Unclassified TARGETS & BIOACTIVITY 0 molecular targets 22 bioactivities · 0 graphs

Bioactivities 22

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

AssayResultTarget enzymeSource detail
Constitutive androstane receptor (CAR) small molecule agonists, cell-based qHTS assay in HepG2 cellsOTHER 6.108 uM; INACTIVENot recorded
pubchem.aid:2202728
assay
Constitutive androstane receptor (CAR) small molecule agonists, cell-based qHTS assay in HepG2 cells
evidence
  • reference
    pubchem.aid:2202728
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202728, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
INACTIVE
measurement type
OTHER
value
6.108
units
uM
Constitutive androstane receptor (CAR) small molecule agonists, cell-based qHTS assay in HepG2 cellsOTHER 6.108 uM; INACTIVENot recorded
pubchem.aid:2202728
assay
Constitutive androstane receptor (CAR) small molecule agonists, cell-based qHTS assay in HepG2 cells
evidence
  • reference
    pubchem.aid:2202728
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202728, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession ADZ17385 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
INACTIVE
measurement type
OTHER
value
6.108
units
uM
GF-AFC viability counterscreen for inhibitors of alpha-synuclein gene (SNCA) expressionOTHER 0.63 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1671193
assay
GF-AFC viability counterscreen for inhibitors of alpha-synuclein gene (SNCA) expression
evidence
  • reference
    pubchem.aid:1671193
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1671193, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
0.63
units
uM
P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screenOTHER 4.8499 uM; ACTIVENot recorded
PMID:31515284
assay
P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen
evidence
  • reference
    PMID:31515284
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1346987, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
4.8499
units
uM
Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds.OTHER 1.7756 uM; INACTIVENot recorded
pubchem.aid:1845221
assay
Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds.
evidence
  • reference
    pubchem.aid:1845221
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1845221, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
INACTIVE
measurement type
OTHER
value
1.7756
units
uM
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)OTHER 0.7592 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1845191
assay
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
evidence
  • reference
    pubchem.aid:1845191
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1845191, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
0.7592
units
uM
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)OTHER 0.7592 uM; NOT_DETERMINEDUniProtKB:P07203
pubchem.aid:1845191
assay
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
evidence
  • reference
    pubchem.aid:1845191
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1845191, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
0.7592
units
uM
target enzyme
UniProtKB:P07203
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)OTHER 4.826 uM; ACTIVENot recorded
pubchem.aid:1645877
assay
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
evidence
  • reference
    pubchem.aid:1645877
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645877, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
4.826
units
uM
activity class
ENZYME_INHIBITOR
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)OTHER 4.826 uM; ACTIVEUniProtKB:O96028
pubchem.aid:1645877
assay
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
evidence
  • reference
    pubchem.aid:1645877
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645877, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
4.826
units
uM
target enzyme
UniProtKB:O96028
activity class
ENZYME_INHIBITOR
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)OTHER 6.8169 uM; ACTIVENot recorded
pubchem.aid:1645876
assay
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
evidence
  • reference
    pubchem.aid:1645876
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645876, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
6.8169
units
uM
activity class
ENZYME_INHIBITOR
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)OTHER 6.8169 uM; ACTIVEUniProtKB:O96028
pubchem.aid:1645876
assay
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
evidence
  • reference
    pubchem.aid:1645876
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1645876, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
6.8169
units
uM
target enzyme
UniProtKB:O96028
activity class
ENZYME_INHIBITOR
Primary qHTS for small molecule compounds that upregulate eGFP-tagged delta133p53alpha (in N-terminal) cells.OTHER 3.1575 uM; NOT_DETERMINEDNot recorded
pubchem.aid:2060322
assay
Primary qHTS for small molecule compounds that upregulate eGFP-tagged delta133p53alpha (in N-terminal) cells.
evidence
  • reference
    pubchem.aid:2060322
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2060322, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
3.1575
units
uM
Primary qHTS for small molecule compounds that upregulate eGFP-tagged delta133p53alpha (in N-terminal) cells.OTHER 3.1575 uM; NOT_DETERMINEDNot recorded
pubchem.aid:2060322
assay
Primary qHTS for small molecule compounds that upregulate eGFP-tagged delta133p53alpha (in N-terminal) cells.
evidence
  • reference
    pubchem.aid:2060322
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2060322, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001119587 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
3.1575
units
uM
Primary qHTS to identify anti-liver cancer compounds using libraries of approved drugs and bioactive compoundsOTHER 1.9953 uM; ACTIVENot recorded
pubchem.aid:2202548
assay
Primary qHTS to identify anti-liver cancer compounds using libraries of approved drugs and bioactive compounds
evidence
  • reference
    pubchem.aid:2202548
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202548, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
1.9953
units
uM
activity class
CYTOTOXIC
Primary redox qHTS assay for identification of artifact compounds.OTHER 6.3 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1845223
assay
Primary redox qHTS assay for identification of artifact compounds.
evidence
  • reference
    pubchem.aid:1845223
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1845223, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
6.3
units
uM
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cellsOTHER 5.4417 uM; ACTIVENot recorded
pubchem.aid:1963824
assay
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells
evidence
  • reference
    pubchem.aid:1963824
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963824, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
5.4417
units
uM
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cellsOTHER 5.4417 uM; ACTIVEUniProtKB:P43405
pubchem.aid:1963824
assay
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells
evidence
  • reference
    pubchem.aid:1963824
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963824, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
5.4417
units
uM
target enzyme
UniProtKB:P43405
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 cellsOTHER 3.8524 uM; ACTIVENot recorded
pubchem.aid:1963823
assay
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 cells
evidence
  • reference
    pubchem.aid:1963823
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963823, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
3.8524
units
uM
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 cellsOTHER 3.8524 uM; ACTIVEUniProtKB:P43405
pubchem.aid:1963823
assay
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 cells
evidence
  • reference
    pubchem.aid:1963823
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963823, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
ACTIVE
measurement type
OTHER
value
3.8524
units
uM
target enzyme
UniProtKB:P43405
Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput ScreeningACTIVENot recorded
PMID:31498718
assay
Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening
evidence
  • reference
    PMID:31498718
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1296008, deposited by NCGC; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approved drugs and bioactive compoundsACTIVENot recorded
pubchem.aid:1345084
assay
Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approved drugs and bioactive compounds
evidence
  • reference
    pubchem.aid:1345084
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1345084, deposited by NCGC; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma treatmentACTIVENot recorded
pubchem.aid:1296009
assay
qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma treatment
evidence
  • reference
    pubchem.aid:1296009
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1296009, deposited by NCGC; assay type Confirmatory.
call
ACTIVE

Explore across X-Mech

AntibioticMech (beauvericin) ↗ MediaIngredientMech (naturalproductmech:mibig-4c106eac10) ↗ TaxonMech: Beauveria bassiana (NCBITaxon:176275) ↗ PathwayMech (mibig:BGC0000313) ↗

Provenance

Source conceptSourceVersion
BGC0000313MIBIG4

This page is generated from data/natural_products/unclassified/beauvericin.yaml, which is generated from the committed inventories. Neither is edited by hand.