AntibioticMech

2'-N-ethylnetilmicin

antibioticmech:aro-ab7143cd24 ·ANTIBACTERIAL ·MINTED SEEDED

2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. — PMID:8385262

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

aminoglycoside antibioticARO:0000016

Strictly broader compounds or drug classes this molecule belongs to.

Chemical structure

Computed structure properties
Molecular formulaC23H45N5O7
Charge0
Average mass503.6 Da
Monoisotopic mass503.33189879 Da
SourcePubChem · retrieved 2026-08-29
InChIKeyJWKYPUZBLKYBRK-OXMUXZJXSA-N

SMILES

CCN[C@@H]1CC=C(O[C@@H]1O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@](CO3)(C)O)NC)O)NCC)N)CN

InChI

InChI=1S/C23H45N5O7/c1-5-27-14-8-7-12(10-24)33-21(14)34-18-13(25)9-15(28-6-2)19(16(18)29)35-22-17(30)20(26-4)23(3,31)11-32-22/h7,13-22,26-31H,5-6,8-11,24-25H2,1-4H3/t13-,14+,15+,16-,17+,18+,19-,20+,21+,22+,23-/m0/s1

Cross-references

Equivalent identifiers for this same structure in other resources.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
SourceNative IDLabelMinted CURIEVersion
ARO ARO:3007378 2'-N-ethylnetilmicin antibioticmech:aro-ab7143cd24 2026-08-30

Resistance mechanisms

47 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_INACTIVATION 47
ANTIBIOTIC_INACTIVATION
DeterminantARO IDOrganismGene familiesEvidence
AAC(3)-IIa ARO:3002533 not organism-specific —
  • ARO:3002533 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(3)-IIb ARO:3002534 not organism-specific —
  • ARO:3002534 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(3)-IIc ARO:3002535 not organism-specific —
  • ARO:3002535 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(3)-IId ARO:3004623 not organism-specific —
  • ARO:3004623 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(3)-IIe ARO:3004621 not organism-specific —
  • ARO:3004621 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(3)-IIg ARO:3005085 not organism-specific —
  • ARO:3005085 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(3)-IVa ARO:3002539 not organism-specific —
  • ARO:3002539 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-I-48 ARO:3004638 not organism-specific —
  • ARO:3004638 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-I30 ARO:3002588 not organism-specific —
  • ARO:3002588 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-IIa ARO:3002594 not organism-specific —
  • ARO:3002594 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-IIb ARO:3002595 not organism-specific —
  • ARO:3002595 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-IIc ARO:3002596 not organism-specific —
  • ARO:3002596 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ia ARO:3002545 not organism-specific —
  • ARO:3002545 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iaa ARO:3002571 not organism-specific —
  • ARO:3002571 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iad ARO:3002572 not organism-specific —
  • ARO:3002572 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iae ARO:3002573 not organism-specific —
  • ARO:3002573 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iaf ARO:3002574 not organism-specific —
  • ARO:3002574 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iai ARO:3002575 not organism-specific —
  • ARO:3002575 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iaj ARO:3003677 not organism-specific —
  • ARO:3003677 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iak ARO:3003199 not organism-specific —
  • ARO:3003199 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ian ARO:3003200 not organism-specific —
  • ARO:3003200 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iap ARO:3007204 not organism-specific —
  • ARO:3007204 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ic ARO:3002549 not organism-specific —
  • ARO:3002549 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ie-APH(2'')-Ia bifunctional protein ARO:3002597 not organism-specific —
  • ARO:3002597 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-If ARO:3002553 not organism-specific —
  • ARO:3002553 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ig ARO:3002554 not organism-specific —
  • ARO:3002554 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ih ARO:3002555 not organism-specific —
  • ARO:3002555 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ii ARO:3002556 not organism-specific —
  • ARO:3002556 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iid ARO:3002589 not organism-specific —
  • ARO:3002589 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iih ARO:3002590 not organism-specific —
  • ARO:3002590 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ij ARO:3002557 not organism-specific —
  • ARO:3002557 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ik ARO:3002558 not organism-specific —
  • ARO:3002558 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Il ARO:3004635 not organism-specific —
  • ARO:3004635 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Im ARO:3004629 not organism-specific —
  • ARO:3004629 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ip ARO:3002559 not organism-specific —
  • ARO:3002559 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iq ARO:3002560 not organism-specific —
  • ARO:3002560 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ir ARO:3002561 not organism-specific —
  • ARO:3002561 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Is ARO:3002562 not organism-specific —
  • ARO:3002562 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Isa ARO:3002563 not organism-specific —
  • ARO:3002563 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-It ARO:3002564 not organism-specific —
  • ARO:3002564 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iu ARO:3002565 not organism-specific —
  • ARO:3002565 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iv ARO:3002566 not organism-specific —
  • ARO:3002566 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iw ARO:3002567 not organism-specific —
  • ARO:3002567 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Ix ARO:3002568 not organism-specific —
  • ARO:3002568 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iy ARO:3002569 not organism-specific —
  • ARO:3002569 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
AAC(6')-Iz ARO:3002570 not organism-specific —
  • ARO:3002570 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)
ANT(3'')-II-AAC(6')-IId bifunctional protein ARO:3002598 not organism-specific —
  • ARO:3002598 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007378 (2'-N-ethylnetilmicin); database assertion, not a primary citation.)

Curation history

  1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Seeded from data/raw/ inventories (ARO)

  2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.