5-chloro-7-iodoquinolin-8-ol

CHEBI:74460 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:36683
Label unavailable CHEBI:37142
Label unavailable CHEBI:38775

Chemical structure

Computed structure properties
Molecular formula	C9H5ClINO
Charge	0
Average mass	305.502 Da
Monoisotopic mass	304.91044 Da
Source	ChEBI
InChIKey	QCDFBFJGMNKBDO-UHFFFAOYSA-N

SMILES

Oc1c(I)cc(Cl)c2cccnc12

InChI

InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

Also called

clioquinol (INN)— chebi
clioquinolum (INN)— chebi
5-Chlor-7-jod-8-hydroxy-chinolin (EXACT_SYNONYM)— chebi
5-chloro-7-iodo-8-hydroxyquinoline (EXACT_SYNONYM)— chebi
5-chloro-7-iodo-8-quinolinol (EXACT_SYNONYM)— chebi
5-chloro-8-hydroxy-7-iodoquinoline (EXACT_SYNONYM)— chebi
7-iodo-5-chloro-8-hydroxyquinoline (EXACT_SYNONYM)— chebi
7-iodo-5-chloroxine (EXACT_SYNONYM)— chebi
chloroiodoquin (EXACT_SYNONYM)— chebi
iodochlorhydroxyquinoline (EXACT_SYNONYM)— chebi
iodochlorohydroxyquin (EXACT_SYNONYM)— chebi
iodochloroxyquinoline (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antimicrobial agent CHEBI:33281
antibacterial agent CHEBI:33282
antifungal agent CHEBI:35718
antiprotozoal drug CHEBI:35820

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:74460`	5-chloro-7-iodoquinolin-8-ol	`antibioticmech:chebi-781dacc9d8`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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