AntibioticMech

5-chloro-7-iodoquinolin-8-ol

CHEBI:74460 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease. — ChEBI

Classification

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:36683 CHEBI:36683
• CHEBI:37142 CHEBI:37142
• CHEBI:38775 CHEBI:38775

Chemical structure

Computed structure properties

Molecular formula	C9H5ClINO
Charge	0
Average mass	305.502 Da
Monoisotopic mass	304.91044 Da
Source	ChEBI
InChIKey	QCDFBFJGMNKBDO-UHFFFAOYSA-N

SMILES

Oc1c(I)cc(Cl)c2cccnc12

InChI

InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

Also called

• clioquinol (INN)— chebi
• clioquinolum (INN)— chebi
• 5-Chlor-7-jod-8-hydroxy-chinolin (EXACT_SYNONYM)— chebi
• 5-chloro-7-iodo-8-hydroxyquinoline (EXACT_SYNONYM)— chebi
• 5-chloro-7-iodo-8-quinolinol (EXACT_SYNONYM)— chebi
• 5-chloro-8-hydroxy-7-iodoquinoline (EXACT_SYNONYM)— chebi
• 7-iodo-5-chloro-8-hydroxyquinoline (EXACT_SYNONYM)— chebi
• 7-iodo-5-chloroxine (EXACT_SYNONYM)— chebi
• chloroiodoquin (EXACT_SYNONYM)— chebi
• iodochlorhydroxyquinoline (EXACT_SYNONYM)— chebi
• iodochlorohydroxyquin (EXACT_SYNONYM)— chebi
• iodochloroxyquinoline (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• cas:130-26-7
• drugbank:DB04815
• drugcentral:681
• kegg.drug:D03538
• lincs.smallmolecule:LSM-2186
• patent:DE117767
• patent:US641491
• pdb-ccd:CQL
• reaxys:153637
• wikipedia.en:Clioquinol

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:33281 CHEBI:33281
• CHEBI:33282 CHEBI:33282
• CHEBI:35718 CHEBI:35718
• CHEBI:35820 CHEBI:35820

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
CHEBI	CHEBI:74460	5-chloro-7-iodoquinolin-8-ol	antibioticmech:chebi-781dacc9d8	2026-08-30

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.