A201A
antibioticmech:aro-e83eaf8a8a
·ANTIBACTERIAL
·MINTED
SEEDED
A201A is a nucleoside antibiotic. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site. — PMID:26028538
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
nucleoside antibioticARO:3000034
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C37H50N6O14 |
|---|
| Charge | 0 |
|---|
| Average mass | 802.8 Da |
|---|
| Monoisotopic mass | 802.33850029 Da |
|---|
| Source | PubChem · retrieved 2026-08-29 |
|---|
| InChIKey | HELPZWNRUYNCJQ-QWJSOBSRSA-N |
|---|
SMILES
CC1C(C(C(C(O1)OC/C(=C/2\C(C(C(O2)OC3=CC=C(C=C3)/C=C(\C)/C(=O)NC4C(OC(C4O)N5C=NC6=C5N=CN=C6N(C)C)CO)O)O)/OC)O)OC)OC
InChI
InChI=1S/C37H50N6O14/c1-17(34(49)41-23-21(13-44)56-35(25(23)45)43-16-40-24-32(42(3)4)38-15-39-33(24)43)12-19-8-10-20(11-9-19)55-37-27(47)26(46)30(57-37)22(50-5)14-53-36-28(48)31(52-7)29(51-6)18(2)54-36/h8-12,15-16,18,21,23,25-29,31,35-37,44-48H,13-14H2,1-7H3,(H,41,49)/b17-12+,30-22-
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3007639 |
A201A |
antibioticmech:aro-e83eaf8a8a |
2026-08-30 |
Resistance mechanisms
3 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_PROTECTION 3
ANTIBIOTIC_TARGET_PROTECTION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Clostridioides difficile cplR |
ARO:3007637 |
not organism-specific |
— |
- ARO:3007637 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007639 (A201A); database assertion, not a primary citation.)
|
| Neobacillus vireti vmlR2 |
ARO:3007646 |
not organism-specific |
— |
- ARO:3007646 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007639 (A201A); database assertion, not a primary citation.)
|
| vmlR |
ARO:3004476 |
not organism-specific |
— |
- ARO:3004476 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007639 (A201A); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.