AFN-1252

antibioticmech:curator-8edc5e6516 ·ANTIBACTERIAL ·MINTED PROPOSED

A FabI inhibitor with narrow-spectrum antistaphylococcal antibacterial activity. — DOI:10.1128/AAC.00400-09

Chemical structure

Computed structure properties
Molecular formula	C22H21N3O3
Charge	0
Source	https://pubchem.ncbi.nlm.nih.gov/compound/10407120 · retrieved 2026-09-07
InChIKey	QXTWSUQCXCWEHF-JXMROGBWSA-N

SMILES

CC1=C(OC2=CC=CC=C12)CN(C)C(=O)/C=C/C3=CC4=C(NC(=O)CC4)N=C3

InChI

InChI=1S/C22H21N3O3/c1-14-17-5-3-4-6-18(17)28-19(14)13-25(2)21(27)10-7-15-11-16-8-9-20(26)24-22(16)23-12-15/h3-7,10-12H,8-9,13H2,1-2H3,(H,23,24,26)/b10-7+

Also called

afabicin desphosphono (EXACT_SYNONYM)— curator
DEBIO-1452 (EXACT_SYNONYM)— curator

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

pubchem.compound:10407120

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antibacterial agent CHEBI:33282

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version	Evidence
CURATOR	`DOI:10.1128/AAC.00400-09#afn-1252`	AFN-1252	`antibioticmech:curator-8edc5e6516`	2026-09-07	DOI:10.1128/AAC.00400-09 — "Karlowsky et al. reported that AFN-1252 inhibited all tested clinical Staphylococcus aureus and Staphylococcus epidermidis isolates, including methicillin-resistant isolates, at concentrations of 0.12 micrograms per milliliter or lower." (PubChem CID 10407120 supplies the standard InChI, InChIKey, formula, and isomeric SMILES for AFN-1252.)

Curation history

PROPOSED_FROM_CURATOR_INVENTORY 2026-09-07 · seed_from_sources
Proposed from curation/curator_antibiotics.tsv

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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