Balofloxacin
CHEBI:34553
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
Balofloxacin is an 8-methoxy fluoroquinolone antibiotic. It shows potent bactericidal activity and inhibits the supercoiling activity of DNA gyrase of S. aureus, E. coli, and P. aeruginosa. — PMID:1329626
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
fluoroquinolone antibioticARO:0000001
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C20H24FN3O4 |
|---|
| Charge | 0 |
|---|
| Average mass | 389.427 Da |
|---|
| Monoisotopic mass | 389.17508 Da |
|---|
| Source | ChEBI |
|---|
| InChIKey | MGQLHRYJBWGORO-LLVKDONJSA-N |
|---|
SMILES
CN[C@@H]1CCCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2OC)C1
InChI
InChI=1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27)/t11-/m1/s1
Also called
- balofloxacine (INN)— chebi
- balofloxacino (INN)— chebi
- Q-Roxin (EXACT_SYNONYM)— chebi
- balofloxacin hydrate (EXACT_SYNONYM)— chebi
- 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylaminopiperidine-1-yl)-4-oxoquinoline-3-carboxylic acid (EXACT_SYNONYM)— aro
- Q 35 (EXACT_SYNONYM)— aro
- Q-35 (EXACT_SYNONYM)— aro
Cross-references
Equivalent identifiers for this same structure in other resources.
Activity roles
Every antimicrobial role a source asserts for this compound — the
unreduced evidence behind its antimicrobial_class.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3004130 |
balofloxacin |
antibioticmech:aro-ea4bb6f903 |
2026-08-30 |
| CHEBI |
CHEBI:34553 |
Balofloxacin |
antibioticmech:chebi-01b857fb5b |
2026-08-30 |
Resistance mechanisms
1 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
REDUCED_PERMEABILITY 1
REDUCED_PERMEABILITY
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Escherichia coli LamB |
ARO:3004126 |
not organism-specific |
— |
- ARO:3004126 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004130 (balofloxacin); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.