AntibioticMech

bicozamycin

CHEBI:60584 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli. — ChEBI

Classification

bicyclomycin-like antibioticARO:3007150

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:35990 CHEBI:35990
• CHEBI:38295 CHEBI:38295
• ARO:3007150 ARO:3007150

Chemical structure

Computed structure properties

Molecular formula	C12H18N2O7
Charge	0
Average mass	302.283 Da
Monoisotopic mass	302.1114 Da
Source	ChEBI
InChIKey	WOUDXEYYJPOSNE-VKZDFBPFSA-N

SMILES

C=C1CCO[C@]2([C@@H](O)[C@@](C)(O)CO)NC(=O)[C@@]1(O)NC2=O

InChI

InChI=1S/C12H18N2O7/c1-6-3-4-21-12(7(16)10(2,19)5-15)9(18)13-11(6,20)8(17)14-12/h7,15-16,19-20H,1,3-5H2,2H3,(H,13,18)(H,14,17)/t7-,10-,11+,12-/m0/s1

Also called

• bicozamicina (INN)— chebi
• bicozamycine (INN)— chebi
• bicozamycinum (INN)— chebi
• Bicozamycin (EXACT_SYNONYM)— chebi
• Bicyclomycin (EXACT_SYNONYM)— chebi
• aizumycin (EXACT_SYNONYM)— chebi
• Aizumycin (EXACT_SYNONYM)— aro
• Bacfeed (EXACT_SYNONYM)— aro
• Bacteron (EXACT_SYNONYM)— aro
• Bicozamicina (EXACT_SYNONYM)— aro
• Bicozamycine (EXACT_SYNONYM)— aro
• Bicozamycinum (EXACT_SYNONYM)— aro

Cross-references

Equivalent identifiers for this same structure in other resources.

• ARO:0000055
• cas:38129-37-2
• kegg.compound:C11259
• knapsack:C00018850
• reaxys:566286
• chembl:CHEMBL1231250
• pubchem.compound:65807

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:33282 CHEBI:33282

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
ARO	ARO:0000055	bicyclomycin	antibioticmech:aro-b86b27b1dd	2026-08-30
CHEBI	CHEBI:60584	bicozamycin	antibioticmech:chebi-b84bb7c116	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

rho transcription terminator factor PROTEIN DIRECT_BINDING_TARGET

ARO:3000736

CARD/ARO database assertion; target organism, strain, and assay are not specified. Rho termination factor is asserted as the antibiotic target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

• ARO:3000736 (CARD/ARO asserts targeted_by_antibiotic ARO:0000055 (bicyclomycin); database assertion, not a primary citation.)

Resistance mechanisms

1 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_EFFLUX 1

ANTIBIOTIC_EFFLUX

Determinant	ARO ID	Organism	Gene families	Evidence
bcr-1	ARO:3003801	not organism-specific	—	ARO:3003801 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000055 (bicyclomycin); database assertion, not a primary citation.)

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO, CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.