brodimoprim

CHEBI:131726 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

An aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group. — ChEBI

Classification

diaminopyrimidine antibioticARO:3000171

Strictly broader compounds or drug classes this molecule belongs to.

• Label unavailable CHEBI:37149
• Label unavailable CHEBI:38338
• Label unavailable CHEBI:51683
• diaminopyrimidine antibiotic ARO:3000171

Chemical structure

SMILES

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1Br

InChI

InChI=1S/C13H15BrN4O2/c1-19-9-4-7(5-10(20-2)11(9)14)3-8-6-17-13(16)18-12(8)15/h4-6H,3H2,1-2H3,(H4,15,16,17,18)

Also called

• brodimoprima (INN)— chebi
• brodimoprime (INN)— chebi
• brodimoprimum (INN)— chebi
• 5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine-2,4-diamine (EXACT_SYNONYM)— chebi
• 2,4-diamino-5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine (EXACT_SYNONYM)— chebi
• Ro 10-5970 (EXACT_SYNONYM)— chebi
• Ro 105970 (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

• brodimoprimARO:3000269
• cas:56518-41-3
• reaxys:760113
• chembl:CHEMBL31891
• pubchem.compound:68760

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

• drugcentral:398
• kegg.drug:D07238

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

• wikipedia.en:Brodimoprim

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• antibacterial drug CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive dihydrofolate reductase PROTEIN DIRECT_BINDING_TARGET

ARO:3000745

CARD/ARO database assertion; target organism, strain, and assay are not specified. Dihydrofolate reductase is asserted as the inhibited enzyme. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

• ARO:3000745 (CARD/ARO asserts targeted_by_antibiotic ARO:3000269 (brodimoprim); database assertion, not a primary citation.)

Mechanism summary

Mode of action

FOLATE_PATHWAY_INHIBITION host shared target — Assigned from ChEBI role CHEBI:50683 (EC 1.5.1.3 (dihydrofolate reductase) inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO, CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

Explore across X-Mech: MediaIngredientMech (brodimoprim) · CultureMech · NaturalProductMech · PathwayMech · TraitMech