cefaclor
CHEBI:3478
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton. — ChEBI
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
cephalosporinARO:0000032
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C15H14ClN3O4S |
|---|
| Charge | 0 |
|---|
| Average mass | 367.814 Da |
|---|
| Monoisotopic mass | 367.03935 Da |
|---|
| Source | ChEBI |
|---|
| InChIKey | QYIYFLOTGYLRGG-GPCCPHFNSA-N |
|---|
SMILES
[H][C@]12SCC(Cl)=C(C(=O)O)N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1
InChI
InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1
Also called
- cefaclorum (INN)— chebi
- (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (EXACT_SYNONYM)— chebi
- 7β-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-3,4-didehydrocepham-4-carboxylic acid (EXACT_SYNONYM)— chebi
- 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid (EXACT_SYNONYM)— chebi
- CCL (EXACT_SYNONYM)— chebi
- Cefaclor (EXACT_SYNONYM)— chebi
- Cefaclor anhydrous (EXACT_SYNONYM)— chebi
- Cephaclor (EXACT_SYNONYM)— chebi
- CEC (EXACT_SYNONYM)— aro
- ceclor (EXACT_SYNONYM)— aro
- cephaclor (EXACT_SYNONYM)— aro
Cross-references
Equivalent identifiers for this same structure in other resources.
Activity roles
Every antimicrobial role a source asserts for this compound — the
unreduced evidence behind its antimicrobial_class.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3000644 |
cefaclor |
antibioticmech:aro-05c1d0a19e |
2026-08-30 |
| CHEBI |
CHEBI:3478 |
cefaclor |
antibioticmech:chebi-cfd6d47172 |
2026-08-30 |
Molecular targets
The molecular entity or process this compound acts on. Each target
carries evidence — this is a mechanistic claim, not a classification.
beta-lactam sensitive penicillin-binding protein PROTEIN DIRECT_BINDING_TARGET
ARO:3000749
CARD/ARO database assertion; target organism, strain, and assay are not specified. Penicillin-binding proteins are asserted as inhibited transpeptidases. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).
- ARO:3000749 (CARD/ARO asserts targeted_by_antibiotic ARO:3000644 (cefaclor); database assertion, not a primary citation.)
Resistance mechanisms
1 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_ALTERATION 1
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics |
ARO:3004446 |
not organism-specific |
— |
- ARO:3004446 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000644 (cefaclor); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.