cefaloridine

CHEBI:3537 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

cephalosporinARO:0000032

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:23066 CHEBI:23066
CHEBI:72588 CHEBI:72588
CHEBI:88225 CHEBI:88225
ARO:0000032 ARO:0000032

Chemical structure

Computed structure properties
Molecular formula	C19H17N3O4S2
Charge	0
Average mass	415.496 Da
Monoisotopic mass	415.06605 Da
Source	ChEBI
InChIKey	CZTQZXZIADLWOZ-CRAIPNDOSA-N

SMILES

[H][C@]12SCC(C[n+]3ccccc3)=C(C(=O)[O-])N1C(=O)[C@H]2NC(=O)Cc1cccs1

InChI

InChI=1S/C19H17N3O4S2/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21/h1-8,15,18H,9-11H2,(H-,20,23,25,26)/t15-,18-/m1/s1

Also called

cefaloridina (INN)— chebi
cefaloridinum (INN)— chebi
3-(pyridinium-1-ylmethyl)-7β-[(2-thienylacetyl)amino]-3,4-didehydrocepham-4-carboxylate (EXACT_SYNONYM)— chebi
(6R,7R)-8-oxo-3-(pyridinium-1-ylmethyl)-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (EXACT_SYNONYM)— chebi
7-((2-Thienyl)acetamido)-3-(1-pyridylmethyl)cephalosporanic acid (EXACT_SYNONYM)— chebi
Cefaloridin (EXACT_SYNONYM)— chebi
Cefalorizin (EXACT_SYNONYM)— chebi
Ceflorin (EXACT_SYNONYM)— chebi
Cepaloridin (EXACT_SYNONYM)— chebi
Cepalorin (EXACT_SYNONYM)— chebi
Cephaloridin (EXACT_SYNONYM)— chebi
Cephaloridine (EXACT_SYNONYM)— chebi
Cephaloridinum (EXACT_SYNONYM)— chebi
N-(7-((2-Thienyl)acetamido)ceph-3-em-3-ylmethyl)pyridinium-4-carboxylate (EXACT_SYNONYM)— chebi
N-(7-(2'-Thienylacetamidoceph-3-ylmethyl))-pyridinium-2-carboxylate (EXACT_SYNONYM)— chebi
Cefaloridine (EXACT_SYNONYM)— aro
Cephalomycine (EXACT_SYNONYM)— aro
Ceporin (EXACT_SYNONYM)— aro

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3004129
cas:50-59-9
drugcentral:573
kegg.compound:C11754
kegg.drug:D01075
reaxys:4166301
wikipedia.en:Cephaloridine
chembl:CHEMBL316157
pubchem.compound:5773

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281
CHEBI:36047 CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3004129`	cephaloridine	`antibioticmech:aro-5a4dbaa715`	2026-08-30
CHEBI	`CHEBI:3537`	cefaloridine	`antibioticmech:chebi-c8d08a52f9`	2026-08-30

Resistance mechanisms

4 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_INACTIVATION 3

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
CDA-1	ARO:3007650	not organism-specific	—	ARO:3007650 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004129 (cephaloridine); database assertion, not a primary citation.)
CblA beta-lactamase	ARO:3002998	not organism-specific	—	ARO:3002998 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004129 (cephaloridine); database assertion, not a primary citation.)
CblA-1	ARO:3002999	not organism-specific	—	ARO:3002999 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004129 (cephaloridine); database assertion, not a primary citation.)

REDUCED_PERMEABILITY 1

REDUCED_PERMEABILITY
Determinant	ARO ID	Organism	Gene families	Evidence
porin OmpC	ARO:3004114	not organism-specific	—	ARO:3004114 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004129 (cephaloridine); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.