cefiderocol

CHEBI:140376 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A fourth-generation siderophore cephalosporin antibiotic having {1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidinium-1-yl}methyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino side groups located at positions 3 and 7 respectively, developed to combat a variety of bacterial pathogens, including β-lactam- and carbapenem-resistant organisms. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

cephalosporinARO:0000032

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:23066 CHEBI:23066
CHEBI:33575 CHEBI:33575
ARO:0000032 ARO:0000032

Chemical structure

Computed structure properties
Molecular formula	C30H34ClN7O10S2
Charge	0
Average mass	752.228 Da
Monoisotopic mass	751.14971 Da
Source	ChEBI
InChIKey	DBPPRLRVDVJOCL-FQRUVTKNSA-N

SMILES

[H][C@]12SCC(C[N+]3(CCNC(=O)c4ccc(O)c(O)c4Cl)CCCC3)=C(C(=O)[O-])N1C(=O)[C@H]2NC(=O)/C(=N\OC(C)(C)C(=O)O)c1csc(N)n1

InChI

InChI=1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1

Also called

cefiderocolum (INN)— chebi
céfidérocol (INN)— chebi
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-({1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidinium-1-yl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (EXACT_SYNONYM)— chebi
GSK 2696266 (EXACT_SYNONYM)— chebi
GSK-2696266 (EXACT_SYNONYM)— chebi
GSK2696266 (EXACT_SYNONYM)— chebi
RSC 649266 (EXACT_SYNONYM)— chebi
S 649266 (EXACT_SYNONYM)— chebi
S-649266 (EXACT_SYNONYM)— chebi
S649266 (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3004474
cas:1225208-94-5
chemspider:52084902
drugbank:DB14879
drugcentral:5352
kegg.drug:D11302
patent:EP2341053
reaxys:21605074
wikipedia.en:Cefiderocol
chembl:CHEMBL3989974
pubchem.compound:77843966

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281
CHEBI:36047 CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3004474`	cefiderocol	`antibioticmech:aro-eabc5c702e`	2026-08-30
CHEBI	`CHEBI:140376`	cefiderocol	`antibioticmech:chebi-1e15875db2`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.