cefiderocol

CHEBI:140376 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A fourth-generation siderophore cephalosporin antibiotic having {1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidinium-1-yl}methyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino side groups located at positions 3 and 7 respectively, developed to combat a variety of bacterial pathogens, including β-lactam- and carbapenem-resistant organisms. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

cephalosporinARO:0000032

Strictly broader compounds or drug classes this molecule belongs to.

cephalosporin CHEBI:23066
Label unavailable CHEBI:33575
cephalosporin ARO:0000032

Chemical structure

Computed structure properties
Molecular formula	C30H34ClN7O10S2
Charge	0
Average mass	752.228 Da
Monoisotopic mass	751.14971 Da
Source	ChEBI
InChIKey	DBPPRLRVDVJOCL-FQRUVTKNSA-N

SMILES

[H][C@]12SCC(C[N+]3(CCNC(=O)c4ccc(O)c(O)c4Cl)CCCC3)=C(C(=O)[O-])N1C(=O)[C@H]2NC(=O)/C(=N\OC(C)(C)C(=O)O)c1csc(N)n1

InChI

InChI=1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1

Also called

cefiderocolum (INN)— chebi
céfidérocol (INN)— chebi
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-({1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidinium-1-yl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (EXACT_SYNONYM)— chebi
GSK 2696266 (EXACT_SYNONYM)— chebi
GSK-2696266 (EXACT_SYNONYM)— chebi
GSK2696266 (EXACT_SYNONYM)— chebi
RSC 649266 (EXACT_SYNONYM)— chebi
S 649266 (EXACT_SYNONYM)— chebi
S-649266 (EXACT_SYNONYM)— chebi
S649266 (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antimicrobial agent CHEBI:33281
antibacterial drug CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3004474`	cefiderocol	`antibioticmech:aro-eabc5c702e`	2026-08-30
CHEBI	`CHEBI:140376`	cefiderocol	`antibioticmech:chebi-1e15875db2`	2026-08-30

Activity spectrum

Measured or curated activity against specific taxa. A number without a method is not an observation — every row here carries an assay.

10 observations · Browse all observations · Complete record (JSON.gz)

Activity observations
Organism	Activity	MIC	Disk diffusion	Assay	Strain	Sample/genome	Evidence
Acinetobacter baumannii NCBITaxon:470	—	16.0 mg/L	—	Broth microdilution cefiderocol MIC; modal MIC reported; CDC/FDA AR Isolate Bank reports an R interpretation without a versioned breakpoint footnote on this isolate page.	0033	BioSample SAMN04014874	Evidence Page data (JSON.gz)
Acinetobacter baumannii NCBITaxon:470	—	16.0 mg/L	—	Broth microdilution cefiderocol MIC; modal MIC reported; interpreted using CLSI 2024 M100 S34 per the CDC/FDA AR Isolate Bank Panel 1227 footnote.	0078	BioSample SAMN04014919	Evidence Page data (JSON.gz)
Acinetobacter baumannii NCBITaxon:470	—	>32.0 mg/L	—	Broth microdilution cefiderocol MIC; modal MIC reported; interpreted using CLSI 2020 M100 S30 per the CDC/FDA AR Isolate Bank Panel 1227 footnote.	0083	BioSample SAMN04014924	Evidence Page data (JSON.gz)
Acinetobacter baumannii NCBITaxon:470	—	>32.0 mg/L	—	Broth microdilution cefiderocol MIC; modal MIC reported; interpreted using CLSI 2024 M100 S34 per the CDC/FDA AR Isolate Bank Panel 1227 footnote.	0088	BioSample SAMN04014929	Evidence Page data (JSON.gz)
Escherichia coli NCBITaxon:562	—	>32.0 mg/L	—	Broth microdilution cefiderocol MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35 per the CDC/FDA AR Isolate Bank Panel 1227 footnote.	0118	BioSample SAMN04014959	Evidence Page data (JSON.gz)
Klebsiella pneumoniae NCBITaxon:573	—	16.0 mg/L	—	Broth microdilution cefiderocol MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35 per the CDC/FDA AR Isolate Bank Panel 1227 footnote.	0143	BioSample SAMN04014984	Evidence Page data (JSON.gz)
Escherichia coli NCBITaxon:562	—	>32.0 mg/L	—	Broth microdilution cefiderocol MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35 per the CDC/FDA AR Isolate Bank Panel 1227 footnote.	0150	BioSample SAMN04014991	Evidence Page data (JSON.gz)
Escherichia coli NCBITaxon:562	—	>64.0 mg/L	—	Broth microdilution cefiderocol MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35 per the CDC/FDA AR Isolate Bank Panel 1227 footnote.	0151	BioSample SAMN04014992	Evidence Page data (JSON.gz)
Escherichia coli NCBITaxon:562	—	>32.0 mg/L	—	Broth microdilution cefiderocol MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35 per the CDC/FDA AR Isolate Bank Panel 1227 footnote.	0162	BioSample SAMN04015003	Evidence Page data (JSON.gz)
Pseudomonas aeruginosa NCBITaxon:287	—	16.0 mg/L	—	Broth microdilution cefiderocol MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35 per the CDC/FDA AR Isolate Bank Panel 1227 footnote.	0246	BioSample SAMN04901636	Evidence Page data (JSON.gz)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories
CURATED_RESISTANT_TAXA 2026-09-13 · codex · LLM-assisted
Added 10 stable-URL CDC/FDA AR Isolate Bank Panel 1227 cefiderocol-resistant MIC observations.
STRUCTURED_ACTIVITY_BIOSAMPLE_ACCESSIONS 2026-09-26 · codex · LLM-assisted
Structured BioSample accessions on 10 activity_spectrum observation(s) where evidence notes already named exactly one accession.

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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