AntibioticMech

cefroxadine

CHEBI:31379 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A first-generation cephalosporin antibiotic having methoxy and [(2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetyl]amino side groups located at positions 3 and 7 respectively. — ChEBI

Classification

cephalosporinARO:0000032

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:23066 CHEBI:23066
• ARO:0000032 ARO:0000032

Chemical structure

Computed structure properties

Molecular formula	C16H19N3O5S
Charge	0
Average mass	365.411 Da
Monoisotopic mass	365.10454 Da
Source	ChEBI
InChIKey	RDMOROXKXONCAL-UEKVPHQBSA-N

SMILES

[H][C@]12SCC(OC)=C(C(=O)O)N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CCC=CC1

InChI

InChI=1S/C16H19N3O5S/c1-24-9-7-25-15-11(14(21)19(15)12(9)16(22)23)18-13(20)10(17)8-5-3-2-4-6-8/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1

Also called

• cefroxadino (INN)— chebi
• cefroxadinum (INN)— chebi
• céfroxadine (INN)— chebi
• 7-{[(2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetyl]amino}-3-methoxy-3,4-didehydrocepham-4-carboxylic acid (EXACT_SYNONYM)— chebi
• (6R,7R)-7-{[(2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetyl]amino}-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (EXACT_SYNONYM)— chebi
• CXD (EXACT_SYNONYM)— chebi
• cephroxadine (EXACT_SYNONYM)— aro

Cross-references

Equivalent identifiers for this same structure in other resources.

• ARO:3009113
• cas:51762-05-1
• drugcentral:557
• kegg.compound:C12979
• kegg.drug:D01528
• reaxys:8165480
• wikipedia.en:Cefroxadine
• chembl:CHEMBL3186538
• pubchem.compound:5284529

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:33281 CHEBI:33281

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
ARO	ARO:3009113	cefroxadine	antibioticmech:aro-137a154cbc	2026-08-30
CHEBI	CHEBI:31379	cefroxadine	antibioticmech:chebi-32ae24ba61	2026-08-30

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO, CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.