ceftiofur
CHEBI:31383
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
Ceftiofur is a third-generation broad spectrum cephalosporin and beta-lactam antibiotic predominantly used in veterinary medicine. It causes cell lysis by disrupting peptidoglycan cross-linkage and cell wall formation by binding to PBPs. — PMID:3631686
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
cephalosporinARO:0000032
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C19H16N5O7S3.Na |
|---|
| Charge | 0 |
|---|
| Average mass | 545.556 Da |
|---|
| Monoisotopic mass | 545.01096 Da |
|---|
| Source | ChEBI |
|---|
| InChIKey | RFLHUYUQCKHUKS-JUODUXDSSA-M |
|---|
SMILES
[H][C@]12SCC(CSC(=O)c3ccco3)=C(C(=O)[O-])N1C(=O)[C@H]2NC(=O)/C(=N\OC)c1csc(N)n1.[Na+]
InChI
InChI=1S/C19H17N5O7S3.Na/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10;/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28);/q;+1/p-1/b23-11-;/t12-,16-;/m1./s1
Also called
- Excenel (EXACT_SYNONYM)— aro
- Naxcel (EXACT_SYNONYM)— aro
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3004006 |
ceftiofur |
antibioticmech:aro-0ad6dfa51b |
2026-08-30 |
Molecular targets
The molecular entity or process this compound acts on. Each target
carries evidence — this is a mechanistic claim, not a classification.
beta-lactam sensitive penicillin-binding protein PROTEIN DIRECT_BINDING_TARGET
ARO:3000749
CARD/ARO database assertion; target organism, strain, and assay are not specified. Penicillin-binding proteins are asserted as inhibited transpeptidases. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).
- ARO:3000749 (CARD/ARO asserts targeted_by_antibiotic ARO:3004006 (ceftiofur); database assertion, not a primary citation.)
Resistance mechanisms
1 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_INACTIVATION 1
ANTIBIOTIC_INACTIVATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| EBR-5 |
ARO:3007437 |
not organism-specific |
— |
- ARO:3007437 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004006 (ceftiofur); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.