AntibioticMech

chalcomycin

CHEBI:80016 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

Produced by Streptomyces bikiniensis. — DOI:10.1139/m63-088

Classification

macrolide antibioticARO:0000000

Strictly broader compounds or drug classes this molecule belongs to.

• ARO:0000000 ARO:0000000

Chemical structure

Computed structure properties

Molecular formula	C35H56O14
Charge	0
Average mass	700.819 Da
Monoisotopic mass	700.36701 Da
Source	ChEBI
InChIKey	KLGADJPDTCIJLO-LJUCOGSUSA-N

SMILES

CO[C@@H]1[C@H](O)[C@@H](C)O[C@@H](OC[C@H]2[C@H]3O[C@@H]3/C=C/C(=O)[C@@](C)(O)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](OC)[C@H]3O)[C@@H](C)/C=C/C(=O)O[C@@H]2C)[C@@H]1OC

InChI

InChI=1S/C35H56O14/c1-17-10-13-26(37)46-20(4)22(16-44-34-32(43-9)31(42-8)27(38)21(5)47-34)30-23(48-30)11-12-25(36)35(6,40)15-18(2)29(17)49-33-28(39)24(41-7)14-19(3)45-33/h10-13,17-24,27-34,38-40H,14-16H2,1-9H3/b12-11+,13-10+/t17-,18-,19+,20+,21+,22+,23+,24-,27+,28+,29+,30+,31+,32+,33-,34+,35-/m0/s1

Cross-references

Equivalent identifiers for this same structure in other resources.

• ARO:3001222
• cas:20283-48-1
• chembl:CHEMBL4076923
• pubchem.compound:6436271

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
ARO	ARO:3001222	chalcomycin	antibioticmech:aro-6574c1f99e	2026-08-30

Resistance mechanisms

3 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 2

ANTIBIOTIC_TARGET_ALTERATION

Determinant	ARO ID	Organism	Gene families	Evidence
ErmV	ARO:3002824	not organism-specific	—	ARO:3002824 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001222 (chalcomycin); database assertion, not a primary citation.)
chrB	ARO:3001302	not organism-specific	—	ARO:3001302 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001222 (chalcomycin); database assertion, not a primary citation.)

ANTIBIOTIC_INACTIVATION 1

ANTIBIOTIC_INACTIVATION

Determinant	ARO ID	Organism	Gene families	Evidence
gimA	ARO:3000463	not organism-specific	—	ARO:3000463 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001222 (chalcomycin); database assertion, not a primary citation.)

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.