chloroxine

CHEBI:59477 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 have been substituted by chlorine. A synthetic antibacterial prepared by chlorination of quinolin-8-ol, it is used for the treatment of dandruff and seborrhoeic dermatitis of the scalp. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:36683 CHEBI:36683
CHEBI:38775 CHEBI:38775

Chemical structure

Computed structure properties
Molecular formula	C9H5Cl2NO
Charge	0
Average mass	214.051 Da
Monoisotopic mass	212.97482 Da
Source	ChEBI
InChIKey	WDFKMLRRRCGAKS-UHFFFAOYSA-N

SMILES

Oc1c(Cl)cc(Cl)c2cccnc12

InChI

InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

Also called

5,7-dichloroquinolin-8-ol (EXACT_SYNONYM)— chebi
5,7-dichlor-8-hydroxychinolin (EXACT_SYNONYM)— chebi
5,7-dichloro-8-hydroxyquinoline (EXACT_SYNONYM)— chebi
5,7-dichloro-8-oxyquinoline (EXACT_SYNONYM)— chebi
5,7-dichloro-8-quinolinol (EXACT_SYNONYM)— chebi
5,7-dichlorooxine (EXACT_SYNONYM)— chebi
5,7-dichloroxine (EXACT_SYNONYM)— chebi
CHQ (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:773-76-2
drugbank:DB01243
drugcentral:611
kegg.drug:D03472
lincs.smallmolecule:LSM-2371
reaxys:153606
wikipedia.en:Chloroxine

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33282 CHEBI:33282
CHEBI:86327 CHEBI:86327

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:59477`	chloroxine	`antibioticmech:chebi-042e1ab9f4`	2026-08-30

Mechanism summary

Clinical status: APPROVED

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.