delamanid
CHEBI:134742
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
A novel nitroimidazole antibiotic for treating Mycobacterium tuberculosis infection. Delamanid inhibits bacterial cell wall growth by mycolic acid synthesis disruption and is particularly effective in combination therapies against multidrug-resistant tuberculosis. — PMID:25210407
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
nitroimidazole antibioticARO:3004115
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C25H25F3N4O6 |
|---|
| Charge | 0 |
|---|
| Average mass | 534.491 Da |
|---|
| Monoisotopic mass | 534.17262 Da |
|---|
| Source | ChEBI |
|---|
| InChIKey | XDAOLTSRNUSPPH-XMMPIXPASA-N |
|---|
SMILES
C[C@]1(COc2ccc(N3CCC(Oc4ccc(OC(F)(F)F)cc4)CC3)cc2)Cn2cc([N+](=O)[O-])nc2O1
InChI
InChI=1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1
Also called
- deltyba (EXACT_SYNONYM)— aro
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3004490 |
delamanid |
antibioticmech:aro-2882d6317b |
2026-08-30 |
Resistance mechanisms
5 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_ALTERATION 5
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Mycobacterium tuberculosis ddn mutation conferring resistance to nitroimidazole antibiotics |
ARO:3007661 |
not organism-specific |
— |
- ARO:3007661 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004490 (delamanid); database assertion, not a primary citation.)
|
| Mycobacterium tuberculosis fbiA with mutation conferring resistance to delamanid |
ARO:3009339 |
not organism-specific |
— |
- ARO:3009339 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004490 (delamanid); database assertion, not a primary citation.)
|
| Mycobacterium tuberculosis fbiB with mutation conferring resistance to delamanid |
ARO:3009340 |
not organism-specific |
— |
- ARO:3009340 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004490 (delamanid); database assertion, not a primary citation.)
|
| Mycobacterium tuberculosis fbiC with mutation conferring resistance to delamanid |
ARO:3009341 |
not organism-specific |
— |
- ARO:3009341 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004490 (delamanid); database assertion, not a primary citation.)
|
| Mycobacterium tuberculosis fgd1 with mutation conferring resistance to delamanid |
ARO:3007849 |
not organism-specific |
— |
- ARO:3007849 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004490 (delamanid); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.