diflunisal

CHEBI:39669 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

Diflunisal is a salicylic acid derivative and aspirin analogue typically used as a nonsteroidal anti-inflammatory drug. It has been shown to exhibit antibiotic activity against Escherichia coli by inhibiting MurA (MurZ), thereby disrupting cell wall synthesis. — PMID:35453279

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

salicylic acid antibioticARO:3007159

Strictly broader compounds or drug classes this molecule belongs to.

salicylic acid antibiotic ARO:3007159

Chemical structure

Computed structure properties
Molecular formula	C13H8F2O3
Charge	0
Average mass	250.2 Da
Monoisotopic mass	250.04415 Da
Source	ChEBI
InChIKey	HUPFGZXOMWLGNK-UHFFFAOYSA-N

SMILES

O=C(O)c1cc(-c2ccc(F)cc2F)ccc1O

InChI

InChI=1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18)

Also called

Adomal (EXACT_SYNONYM)— aro
Dolobid (EXACT_SYNONYM)— aro
Dolobis (EXACT_SYNONYM)— aro
Flovacil (EXACT_SYNONYM)— aro
Fluniget (EXACT_SYNONYM)— aro
Fluodonil (EXACT_SYNONYM)— aro
Flustar (EXACT_SYNONYM)— aro

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3007091`	diflunisal	`antibioticmech:aro-4da855baac`	2026-08-30

Mechanism summary

Clinical status: APPROVED

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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