doripenem

CHEBI:135928 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

Doripenem is a carbapenem with a broad range of activity against Gram-positive and Gram-negative bacteria, and along with meropenem, it is the most active beta-lactam antibiotic against Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis. — PMID:15047550

Classification

carbapenemARO:0000020

Strictly broader compounds or drug classes this molecule belongs to.

• carbapenems CHEBI:46633
• carbapenem ARO:0000020

Chemical structure

SMILES

C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](CNS(N)(=O)=O)C3)[C@H](C)[C@H]12

InChI

InChI=1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1

Also called

• doribax (EXACT_SYNONYM)— chebi
• doripenem hydrate (EXACT_SYNONYM)— chebi
• DOR (EXACT_SYNONYM)— aro

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

• doripenemARO:3000640
• cas:148016-81-3
• hmdb:HMDB0041883
• chembl:CHEMBL491571
• pubchem.compound:73303

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

• drugcentral:4149

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• antimicrobial agent CHEBI:33281
• antibacterial agent CHEBI:33282

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

beta-lactam sensitive penicillin-binding protein PROTEIN DIRECT_BINDING_TARGET

ARO:3000749

CARD/ARO database assertion; target organism, strain, and assay are not specified. Penicillin-binding proteins are asserted as inhibited transpeptidases. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

• ARO:3000749 (CARD/ARO asserts targeted_by_antibiotic ARO:3000640 (doripenem); database assertion, not a primary citation.)

Mechanism summary

Clinical status

APPROVED

Activity spectrum

Measured or curated activity against specific taxa. A number without a method is not an observation — every row here carries an assay.

6 observations · Browse all observations · Complete record (JSON.gz)

Resistance mechanisms

3 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO, CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

6. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

7. RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

8. CURATED_RESISTANT_TAXA 2026-09-12 · codex · LLM-assisted

   Added one stable-URL CDC/FDA AR Isolate Bank doripenem-resistant Acinetobacter baumannii isolate MIC observation.

9. CURATED_RESISTANT_TAXA 2026-09-13 · codex · LLM-assisted

   Added two stable-URL CDC/FDA AR Isolate Bank Panel 10 doripenem-resistant Klebsiella pneumoniae and Escherichia coli MIC observations for AR-0347 and AR-0348.

10. CURATED_RESISTANT_TAXA 2026-09-18 · codex · LLM-assisted

    Added CDC/FDA AR Isolate Bank Panel 1227 isolate 0033 Acinetobacter baumannii doripenem MIC >8 mg/L with interpretation R; preserved source Unknown, BioSample SAMN04014874, Study ID CarbaNP-02, and MLST ST85(Pasteur)/ST1089(Oxford) in evidence notes.

11. CURATED_RESISTANT_TAXA 2026-09-18 · codex · LLM-assisted

    Added one stable-URL CDC/FDA AR Isolate Bank Panel 1227 doripenem-resistant Acinetobacter baumannii MIC observation for AR-0078; preserved source Pus, BioSample SAMN04014919, Study ID CarbaNP-47, and MLST ST229(Pasteur)/ST203(Oxford) in evidence notes.

12. CURATED_RESISTANT_TAXA 2026-09-19 · codex · LLM-assisted

    Added one stable-URL CDC/FDA AR Isolate Bank Panel 1227 doripenem-resistant Acinetobacter baumannii MIC observation for AR-0083; preserved source Unknown, BioSample SAMN04014924, Study ID CarbaNP-52, and MLST ST1(Pasteur)/ST231/1604(Oxford) in evidence notes.

13. STRUCTURED_ACTIVITY_BIOSAMPLE_ACCESSIONS 2026-09-26 · codex · LLM-assisted

    Structured BioSample accessions on 6 activity_spectrum observation(s) where evidence notes already named exactly one accession.

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

Explore across X-Mech: MediaIngredientMech (doripenem) · CultureMech · NaturalProductMech · PathwayMech · TraitMech