AntibioticMech

dragmacidin E

antibioticmech:aro-7a113ada2c ·ANTIBACTERIAL ·MINTED SEEDED

Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. — PMID:38206835

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

bis-indole alkaloid with antibiotic activityARO:3007773

Strictly broader compounds or drug classes this molecule belongs to.

Chemical structure

Computed structure properties
Molecular formulaC25H20BrN7O2
Charge0
Average mass530.4 Da
Monoisotopic mass529.08619 Da
SourcePubChem · retrieved 2026-08-29
InChIKeyZUCSTWKVHHAHLA-REFGNXHDSA-N

SMILES

C[C@@H]1C2=C3C(=CNC3=C(C=C2)O)C4=C([C@@]15CN=C(N5)N)N=C(C(=O)N4)C6=CNC7=C6C=CC(=C7)Br

InChI

InChI=1S/C25H20BrN7O2/c1-10-12-4-5-17(34)21-18(12)15(8-29-21)19-22(25(10)9-30-24(27)33-25)31-20(23(35)32-19)14-7-28-16-6-11(26)2-3-13(14)16/h2-8,10,28-29,34H,9H2,1H3,(H,32,35)(H3,27,30,33)/t10-,25-/m1/s1

Cross-references

Equivalent identifiers for this same structure in other resources.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
SourceNative IDLabelMinted CURIEVersion
ARO ARO:3007777 dragmacidin E antibioticmech:aro-7a113ada2c 2026-08-30

Curation history

  1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Seeded from data/raw/ inventories (ARO)

  2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.