AntibioticMech

dragmacidin F

antibioticmech:aro-6a4094ddb2 ·ANTIBACTERIAL ·MINTED SEEDED

Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. — PMID:38206835

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

bis-indole alkaloid with antibiotic activityARO:3007773

Strictly broader compounds or drug classes this molecule belongs to.

Chemical structure

Computed structure properties
Molecular formulaC25H22BrN7O3
Charge0
Average mass548.4 Da
Monoisotopic mass547.09675 Da
SourcePubChem · retrieved 2026-08-29
InChIKeyIIJUQWOGZFHFTN-FHUFSZDOSA-N

SMILES

C[C@H]1[C@@H]2C[C@@](C(=O)C3C2C(=CN3)C4=CN=C(C(=O)N4)C5=CNC6=C5C=CC(=C6)Br)(C7=C1NC(=N7)N)O

InChI

InChI=1S/C25H22BrN7O3/c1-9-12-5-25(36,21-18(9)32-24(27)33-21)22(34)20-17(12)14(7-29-20)16-8-30-19(23(35)31-16)13-6-28-15-4-10(26)2-3-11(13)15/h2-4,6-9,12,17,20,28-29,36H,5H2,1H3,(H,31,35)(H3,27,32,33)/t9-,12-,17?,20?,25-/m0/s1

Cross-references

Equivalent identifiers for this same structure in other resources.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
SourceNative IDLabelMinted CURIEVersion
ARO ARO:3007778 dragmacidin F antibioticmech:aro-6a4094ddb2 2026-08-30

Curation history

  1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Seeded from data/raw/ inventories (ARO)

  2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.