edeine A
antibioticmech:aro-68a16c2153
·ANTIBACTERIAL
·MINTED
SEEDED
Edeine A is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and spermidine. Edeine A is a mixture of edeine A1 and its inactive isomer, edeine A2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. — PMID:4984939
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
nonribosomal peptide antibioticsARO:3009657
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C33H58N10O10 |
|---|
| Charge | 0 |
|---|
| Average mass | 754.9 Da |
|---|
| Monoisotopic mass | 754.43373809 Da |
|---|
| Source | PubChem · retrieved 2026-08-29 |
|---|
| InChIKey | HENXXJCYASTLGZ-UHFFFAOYSA-N |
|---|
SMILES
C1=CC(=CC=C1C(CC(=O)NCC(C(=O)NC(CN)C(=O)NC(CCCC(C(CC(=O)NCC(=O)NCCCNCCCCN)O)N)C(=O)O)O)N)O
InChI
InChI=1S/C33H58N10O10/c34-11-1-2-12-38-13-4-14-39-30(49)19-41-29(48)16-26(45)22(36)5-3-6-24(33(52)53)42-31(50)25(17-35)43-32(51)27(46)18-40-28(47)15-23(37)20-7-9-21(44)10-8-20/h7-10,22-27,38,44-46H,1-6,11-19,34-37H2,(H,39,49)(H,40,47)(H,41,48)(H,42,50)(H,43,51)(H,52,53)
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3000130 |
edeine A |
antibioticmech:aro-68a16c2153 |
2026-08-30 |
Molecular targets
The molecular entity or process this compound acts on. Each target
carries evidence — this is a mechanistic claim, not a classification.
30S ribosomal subunit P-site RIBOSOMAL_SUBUNIT DIRECT_BINDING_TARGET
ARO:3000756
CARD/ARO database assertion; target organism, strain, and assay are not specified. The 30S P-site is asserted as the target site. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).
- ARO:3000756 (CARD/ARO asserts targeted_by_antibiotic ARO:3000130 (edeine A); database assertion, not a primary citation.)
Resistance mechanisms
2 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_INACTIVATION 1
ANTIBIOTIC_INACTIVATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| EdeQ |
ARO:3004063 |
not organism-specific |
— |
- ARO:3004063 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000130 (edeine A); database assertion, not a primary citation.)
|
ANTIBIOTIC_TARGET_ALTERATION 1
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Escherichia coli 16S rRNA mutation conferring resistance to edeine |
ARO:3003223 |
not organism-specific |
— |
- ARO:3003223 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000130 (edeine A); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.