erythromycin A

CHEBI:42355 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

macrolide antibioticARO:0000000

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:3992 CHEBI:3992
CHEBI:48923 CHEBI:48923
ARO:0000000 ARO:0000000

Chemical structure

Computed structure properties
Molecular formula	C37H67NO13
Charge	0
Average mass	733.937 Da
Monoisotopic mass	733.46124 Da
Source	ChEBI
InChIKey	ULGZDMOVFRHVEP-RWJQBGPGSA-N

SMILES

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

InChI=1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

Also called

eritromicina (INN)— chebi
erythromycin (INN)— chebi
erythromycinum (INN)— chebi
érythromycine (INN)— chebi
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyloxy)-14-ethyl-7,12,13-trihydroxy-6-[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (EXACT_SYNONYM)— chebi
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (EXACT_SYNONYM)— chebi
3''-O-demethylerythromycin (EXACT_SYNONYM)— chebi
Abomacetin (EXACT_SYNONYM)— chebi
ERYTHROMYCIN (EXACT_SYNONYM)— chebi
ERYTHROMYCIN A (EXACT_SYNONYM)— chebi
Erythromycin (EXACT_SYNONYM)— chebi
Erythromycin A (EXACT_SYNONYM)— chebi
Erythromycin C (EXACT_SYNONYM)— chebi
erthromycin (EXACT_SYNONYM)— chebi
Emgel (EXACT_SYNONYM)— aro
Eritromicina (EXACT_SYNONYM)— aro
Erymax (EXACT_SYNONYM)— aro
Erythrocin (EXACT_SYNONYM)— aro
Erythromycine (EXACT_SYNONYM)— aro
Erythromycinum (EXACT_SYNONYM)— aro
N-methylerythromycin A (EXACT_SYNONYM)— aro

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:0000006
beilstein:75000
cas:114-07-8
cas:1675-02-1
drugbank:DB00199
drugcentral:1048
kegg.compound:C01912
kegg.drug:D00140
lincs.smallmolecule:LSM-3416
lipidmaps:LMPK04000006
metacyc.compound:CPD-13804
patent:US2823203
pdb-ccd:ERY
reaxys:75279
chembl:CHEMBL532
pubchem.compound:12560

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:0000006`	erythromycin	`antibioticmech:aro-1ed7584b6e`	2026-08-30
CHEBI	`CHEBI:42355`	erythromycin A	`antibioticmech:chebi-e89c2cf8dd`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

50S ribosomal subunit P-site RIBOSOMAL_SUBUNIT DIRECT_BINDING_TARGET

ARO:3000757

CARD/ARO database assertion; target organism, strain, and assay are not specified. The 50S P-site is asserted as the target site. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000757 (CARD/ARO asserts targeted_by_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)

Mechanism summary

Clinical status: APPROVED

Resistance mechanisms

110 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 51

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	ARO:3005099	not organism-specific	—	ARO:3005099 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Campylobacter jejuni 23S rRNA with mutation conferring resistance to erythromycin	ARO:3004546	not organism-specific	—	ARO:3004546 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Chlamydia trachomatis 23S rRNA with mutation conferring resistance to macrolide antibiotics	ARO:3004174	not organism-specific	—	ARO:3004174 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Chlamydomonas reinhardtii 23S rRNA with mutation conferring resistance to erythromycin	ARO:3004132	not organism-specific	—	ARO:3004132 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Clostridioides difficile 23S rRNA with mutation conferring resistance to erythromycin and clindamycin	ARO:3004654	not organism-specific	—	ARO:3004654 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(33)	ARO:3000599	not organism-specific	—	ARO:3000599 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(34)	ARO:3000600	not organism-specific	—	ARO:3000600 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(35)	ARO:3000604	not organism-specific	—	ARO:3000604 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(36)	ARO:3000605	not organism-specific	—	ARO:3000605 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(37)	ARO:3000392	not organism-specific	—	ARO:3000392 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(38)	ARO:3000601	not organism-specific	—	ARO:3000601 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(39)	ARO:3000602	not organism-specific	—	ARO:3000602 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(41)	ARO:3000603	not organism-specific	—	ARO:3000603 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(42)	ARO:3003106	not organism-specific	—	ARO:3003106 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(43)	ARO:3003205	not organism-specific	—	ARO:3003205 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(44)v	ARO:3003971	not organism-specific	—	ARO:3003971 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(47)	ARO:3003908	not organism-specific	—	ARO:3003908 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(48)	ARO:3004094	not organism-specific	—	ARO:3004094 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(49)	ARO:3004626	not organism-specific	—	ARO:3004626 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(51)	ARO:3007033	not organism-specific	—	ARO:3007033 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(K)	ARO:3004643	not organism-specific	—	ARO:3004643 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Erm(O)-lrm	ARO:3004652	not organism-specific	—	ARO:3004652 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmA	ARO:3000347	not organism-specific	—	ARO:3000347 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmB	ARO:3000375	not organism-specific	—	ARO:3000375 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmC	ARO:3000250	not organism-specific	—	ARO:3000250 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmD	ARO:3000495	not organism-specific	—	ARO:3000495 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmE	ARO:3000326	not organism-specific	—	ARO:3000326 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmF	ARO:3000498	not organism-specific	—	ARO:3000498 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmG	ARO:3000522	not organism-specific	—	ARO:3000522 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmH	ARO:3002823	not organism-specific	—	ARO:3002823 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmN	ARO:3000592	not organism-specific	—	ARO:3000592 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmQ	ARO:3000593	not organism-specific	—	ARO:3000593 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmR	ARO:3000594	not organism-specific	—	ARO:3000594 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmT	ARO:3000595	not organism-specific	—	ARO:3000595 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmV	ARO:3002824	not organism-specific	—	ARO:3002824 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmW	ARO:3001306	not organism-specific	—	ARO:3001306 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmX	ARO:3000596	not organism-specific	—	ARO:3000596 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
ErmY	ARO:3002825	not organism-specific	—	ARO:3002825 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Escherichia coli 23S rRNA with mutation conferring resistance to erythromycin and telithromycin	ARO:3004131	not organism-specific	—	ARO:3004131 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Moraxella catarrhalis 23S rRNA with mutation conferring resistance to macrolide antibiotics	ARO:3004138	not organism-specific	—	ARO:3004138 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MrmA	ARO:3009654	not organism-specific	—	ARO:3009654 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics	ARO:3004176	not organism-specific	—	ARO:3004176 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Mycoplasma pneumoniae 23S rRNA mutation conferring resistance to erythromycin	ARO:3004179	not organism-specific	—	ARO:3004179 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Mycoplasmopsis fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics	ARO:3004177	not organism-specific	—	ARO:3004177 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Propionibacteria 23S rRNA with mutation conferring resistance to macrolide antibiotics	ARO:3004161	not organism-specific	—	ARO:3004161 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Streptococcus pneumoniae 23S rRNA with mutation conferring resistance to macrolide antibiotics	ARO:3004170	not organism-specific	—	ARO:3004170 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Treponema pallidum 23S rRNA with mutation conferring resistance to erythromycin	ARO:3007759	not organism-specific	—	ARO:3007759 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
erm(40)	ARO:3004606	not organism-specific	—	ARO:3004606 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
erm(45)	ARO:3004595	not organism-specific	—	ARO:3004595 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
erm(46)	ARO:3004596	not organism-specific	—	ARO:3004596 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
erm(56)	ARO:3007654	not organism-specific	—	ARO:3007654 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)

ANTIBIOTIC_EFFLUX 32

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
Acinetobacter baumannii AmvA	ARO:3004577	not organism-specific	—	ARO:3004577 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
AxyXY-OprZ	ARO:3004141	not organism-specific	—	ARO:3004141 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
CmeABC	ARO:3000773	not organism-specific	—	ARO:3000773 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
EfrAB	ARO:3003947	not organism-specific	—	ARO:3003947 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Enterobacter cloacae rob	ARO:3004108	not organism-specific	—	ARO:3004108 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Escherichia coli emrE	ARO:3004039	not organism-specific	—	ARO:3004039 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Klebsiella pneumoniae KpnEF	ARO:3004585	not organism-specific	—	ARO:3004585 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Klebsiella pneumoniae KpnGH-TolC	ARO:3004598	not organism-specific	—	ARO:3004598 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
LpeAB	ARO:3004098	not organism-specific	—	ARO:3004098 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MacAB-TolC	ARO:3000545	not organism-specific	—	ARO:3000545 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MdtEF-TolC	ARO:3000788	not organism-specific	—	ARO:3000788 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MexAB-OprM	ARO:3000386	not organism-specific	—	ARO:3000386 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MexCD-OprJ	ARO:3000797	not organism-specific	—	ARO:3000797 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MexJK-OprM	ARO:3003694	not organism-specific	—	ARO:3003694 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MexPQ-OpmE	ARO:3003697	not organism-specific	—	ARO:3003697 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MexVW-OprM	ARO:3003029	not organism-specific	—	ARO:3003029 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MexXY-OprA	ARO:3003038	not organism-specific	—	ARO:3003038 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MexXY-OprM	ARO:3003032	not organism-specific	—	ARO:3003032 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MtrCDE	ARO:3000369	not organism-specific	—	ARO:3000369 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
MuxABC-OpmB	ARO:3004076	not organism-specific	—	ARO:3004076 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Neisseria gonorrhoeae mtrR with mutation conferring resistance	ARO:3004851	not organism-specific	—	ARO:3004851 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Staphylococcus aureus LmrS	ARO:3004572	not organism-specific	—	ARO:3004572 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
aadT	ARO:3007669	not organism-specific	—	ARO:3007669 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
abeS	ARO:3000768	not organism-specific	—	ARO:3000768 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
efmA	ARO:3003954	not organism-specific	—	ARO:3003954 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
hp1184	ARO:3003965	not organism-specific	—	ARO:3003965 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
lmrP	ARO:3003969	not organism-specific	—	ARO:3003969 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mef(B)	ARO:3003107	not organism-specific	—	ARO:3003107 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mef(D)	ARO:3005089	not organism-specific	—	ARO:3005089 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mef(E)	ARO:3000614	not organism-specific	—	ARO:3000614 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mef(F)	ARO:3007044	not organism-specific	—	ARO:3007044 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mreA	ARO:3007050	not organism-specific	—	ARO:3007050 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)

ANTIBIOTIC_INACTIVATION 19

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
EreA	ARO:3000361	not organism-specific	—	ARO:3000361 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
EreA2	ARO:3002826	not organism-specific	—	ARO:3002826 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
EreB	ARO:3000363	not organism-specific	—	ARO:3000363 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
EreD	ARO:3004608	not organism-specific	—	ARO:3004608 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
Mrx	ARO:3003839	not organism-specific	—	ARO:3003839 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mgtA	ARO:3000462	not organism-specific	—	ARO:3000462 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphA	ARO:3000316	not organism-specific	—	ARO:3000316 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphB	ARO:3000318	not organism-specific	—	ARO:3000318 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphC	ARO:3000319	not organism-specific	—	ARO:3000319 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphE	ARO:3003741	not organism-specific	—	ARO:3003741 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphF	ARO:3003071	not organism-specific	—	ARO:3003071 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphG	ARO:3003742	not organism-specific	—	ARO:3003742 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphI	ARO:3003991	not organism-specific	—	ARO:3003991 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphJ	ARO:3004544	not organism-specific	—	ARO:3004544 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphL	ARO:3003072	not organism-specific	—	ARO:3003072 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphM	ARO:3003767	not organism-specific	—	ARO:3003767 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphN	ARO:3004542	not organism-specific	—	ARO:3004542 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
mphO	ARO:3004543	not organism-specific	—	ARO:3004543 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
oleD	ARO:3000865	not organism-specific	—	ARO:3000865 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_PROTECTION 8

ANTIBIOTIC_TARGET_PROTECTION
Determinant	ARO ID	Organism	Gene families	Evidence
mel	ARO:3000616	not organism-specific	—	ARO:3000616 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
msr(G)	ARO:3007042	not organism-specific	—	ARO:3007042 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
msrA	ARO:3000251	not organism-specific	—	ARO:3000251 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
msrB	ARO:3002818	not organism-specific	—	ARO:3002818 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
msrC	ARO:3002819	not organism-specific	—	ARO:3002819 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
msrE	ARO:3003109	not organism-specific	—	ARO:3003109 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
msrF	ARO:3005087	not organism-specific	—	ARO:3005087 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)
msrH	ARO:3005088	not organism-specific	—	ARO:3005088 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000006 (erythromycin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
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RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
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RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
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RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.