AntibioticMech

finafloxacin

CHEBI:85176 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A quinolone that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted at positions 1, 6, 7 and 8 by cyclopropyl, fluoro, hexahydropyrrolo[3,4-b][1,4]oxazin-6-yl and cyano groups respectively; an antibiotic used for treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. — ChEBI

Classification

fluoroquinolone antibioticARO:0000001

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:18379 CHEBI:18379
• CHEBI:23765 CHEBI:23765
• CHEBI:25384 CHEBI:25384
• CHEBI:37143 CHEBI:37143
• CHEBI:50995 CHEBI:50995
• CHEBI:50996 CHEBI:50996
• CHEBI:51454 CHEBI:51454
• ARO:0000001 ARO:0000001

Chemical structure

Computed structure properties

Molecular formula	C20H19FN4O4
Charge	0
Average mass	398.394 Da
Monoisotopic mass	398.13903 Da
Source	ChEBI
InChIKey	FYMHQCNFKNMJAV-HOTGVXAUSA-N

SMILES

[H][C@]12CN(c3c(F)cc4c(=O)c(C(=O)O)cn(C5CC5)c4c3C#N)C[C@]1([H])OCCN2

InChI

InChI=1S/C20H19FN4O4/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28)/t15-,16-/m0/s1

Also called

• Xtoro (BRAND_NAME)— chebi
• 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• ARO:3004732
• cas:209342-40-5
• drugcentral:4920
• kegg.drug:D10575
• patent:WO2011003091
• reaxys:14830297
• wikipedia.en:Finafloxacin
• chembl:CHEMBL1908370
• pubchem.compound:11567473

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:33281 CHEBI:33281
• CHEBI:36047 CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
ARO	ARO:3004732	finafloxacin	antibioticmech:aro-7be13398f4	2026-08-30
CHEBI	CHEBI:85176	finafloxacin	antibioticmech:chebi-1f53164593	2026-08-30

Mechanism summary

Clinical status

APPROVED

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO, CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.