fusidic acid

CHEBI:29013 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

fusidane antibioticARO:3007153

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:19129 CHEBI:19129
CHEBI:26761 CHEBI:26761
CHEBI:35915 CHEBI:35915
CHEBI:36835 CHEBI:36835
CHEBI:47891 CHEBI:47891
CHEBI:79020 CHEBI:79020
ARO:3007153 ARO:3007153

Chemical structure

Computed structure properties
Molecular formula	C31H48O6
Charge	0
Average mass	516.719 Da
Monoisotopic mass	516.34509 Da
Source	ChEBI
InChIKey	IECPWNUMDGFDKC-MZJAQBGESA-N

SMILES

[H][C@@]12[C@H](O)C[C@@]3([H])/C(=C(\CCC=C(C)C)C(=O)O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]1(C)CC[C@@]1([H])[C@H](C)[C@H](O)CC[C@]21C

InChI

InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1

Also called

(2Z)-2-[(17Z)-16β-acetoxy-3α,11α-dihydroxy-4α,8α,10,14β-tetramethyl-5α,9β,13α-gonan-17-ylidene]-6-methylhept-5-enoic acid (EXACT_SYNONYM)— chebi
Fucidin acid (EXACT_SYNONYM)— chebi
Fusidic acid (EXACT_SYNONYM)— chebi
Fusidine (EXACT_SYNONYM)— chebi
Ramycin (EXACT_SYNONYM)— chebi
fucidic acid (EXACT_SYNONYM)— chebi
fucidin (EXACT_SYNONYM)— aro

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3000759
beilstein:5672885
cas:6990-06-3
drugbank:DB02703
drugcentral:1261
hmdb:HMDB0015570
kegg.compound:C06694
kegg.drug:D04281
knapsack:C00023903
lipidmaps:LMPR0106040001
metacyc.compound:CPD0-1606
pdb-ccd:FUA
reaxys:2197692
vsdb:1776
wikipedia.en:Fusidic_acid
chembl:CHEMBL374975
pubchem.compound:3000226

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3000759`	fusidic acid	`antibioticmech:aro-2c6733d01a`	2026-08-30
CHEBI	`CHEBI:29013`	fusidic acid	`antibioticmech:chebi-f32e1be199`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

elongation factor G PROTEIN DIRECT_BINDING_TARGET

ARO:3000730

CARD/ARO database assertion; target organism, strain, and assay are not specified. Elongation factor G is asserted as the antibiotic target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000730 (CARD/ARO asserts targeted_by_antibiotic ARO:3000759 (fusidic acid); database assertion, not a primary citation.)

Mechanism summary

Mode of action: PROTEIN_SYNTHESIS_INHIBITION host shared target — Assigned from ChEBI role CHEBI:48001 (protein synthesis inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Resistance mechanisms

8 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_PROTECTION 4

ANTIBIOTIC_TARGET_PROTECTION
Determinant	ARO ID	Organism	Gene families	Evidence
FusF	ARO:3004663	not organism-specific	—	ARO:3004663 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000759 (fusidic acid); database assertion, not a primary citation.)
fusB	ARO:3003552	not organism-specific	—	ARO:3003552 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000759 (fusidic acid); database assertion, not a primary citation.)
fusC	ARO:3003733	not organism-specific	—	ARO:3003733 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000759 (fusidic acid); database assertion, not a primary citation.)
fusD	ARO:3003731	not organism-specific	—	ARO:3003731 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000759 (fusidic acid); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_ALTERATION 2

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid	ARO:3003735	not organism-specific	—	ARO:3003735 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000759 (fusidic acid); database assertion, not a primary citation.)
Staphylococcus aureus fusE with mutation conferring resistance to fusidic acid	ARO:3003737	not organism-specific	—	ARO:3003737 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000759 (fusidic acid); database assertion, not a primary citation.)

ANTIBIOTIC_EFFLUX 1

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
CmeABC	ARO:3000773	not organism-specific	—	ARO:3000773 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000759 (fusidic acid); database assertion, not a primary citation.)

ANTIBIOTIC_INACTIVATION 1

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
fusH	ARO:3003026	not organism-specific	—	ARO:3003026 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000759 (fusidic acid); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.