GE2270A

CHEBI:29584 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

GE2270A is the model molecule of cyclic thiazolyl peptide elfamycins. GE2270A is produced by Planobispora rosea. Biosynthesis of the molecule has been shown to originate as a ribosomally synthesized peptide that undergoes significant post-translational modification. Clinical use of cyclic thiazolyl peptides is hindered by their low water solubility and bioavailability. — PMID:10625477

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

elfamycin antibioticARO:3001219

Strictly broader compounds or drug classes this molecule belongs to.

elfamycin antibiotic ARO:3001219

Chemical structure

Computed structure properties
Molecular formula	C56H55N15O10S6
Charge	0
Average mass	1290.553 Da
Monoisotopic mass	1289.25806 Da
Source	ChEBI
InChIKey	JMDULECOHIXMNX-UHFFFAOYSA-N

SMILES

CNC(=O)CC1NC(=O)c2csc(n2)-c2ccc(-c3nc(C4=NC(C(=O)N5CCCC5C(N)=O)CO4)cs3)nc2-c2csc(n2)-c2csc(n2)C(C(O)c2ccccc2)NC(=O)CNC(=O)c2nc(sc2COC)C(C(C)C)NC(=O)c2nc1sc2C

InChI

InChI=1S/C56H55N15O10S6/c1-24(2)39-55-70-42(36(87-55)19-80-5)47(77)59-17-38(73)67-43(44(74)26-10-7-6-8-11-26)54-66-34(23-85-54)52-63-31(20-83-52)41-27(50-64-32(21-82-50)46(76)61-29(16-37(72)58-4)53-69-40(25(3)86-53)48(78)68-39)13-14-28(60-41)51-65-33(22-84-51)49-62-30(18-81-49)56(79)71-15-9-12-35(71)45(57)75/h6-8,10-11,13-14,20-24,29-30,35,39,43-44,74H,9,12,15-19H2,1-5H3,(H2,57,75)(H,58,72)(H,59,77)(H,61,76)(H,67,73)(H,68,78)

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3001237`	GE2270A	`antibioticmech:aro-47e9e1ef33`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

elongation factor Tu PROTEIN DIRECT_BINDING_TARGET

ARO:3000731

CARD/ARO database assertion; target organism, strain, and assay are not specified. Elongation factor Tu is asserted as the antibiotic target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000731 (CARD/ARO asserts targeted_by_antibiotic ARO:3001237 (GE2270A); database assertion, not a primary citation.)

Resistance mechanisms

2 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 2

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Enterococcus faecium EF-Tu mutants conferring resistance to GE2270A	ARO:3003438	not organism-specific	—	ARO:3003438 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001237 (GE2270A); database assertion, not a primary citation.)
Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A	ARO:3003361	not organism-specific	—	ARO:3003361 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001237 (GE2270A); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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