gentamicin B
antibioticmech:aro-808cc3b683
·ANTIBACTERIAL
·MINTED
SEEDED
Gentamicin B is a semisynthetic aminoglycoside antibacterial. — PMID:9872733
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
aminoglycoside antibioticARO:0000016
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C19H38N4O10 |
|---|
| Charge | 0 |
|---|
| Average mass | 482.5 Da |
|---|
| Monoisotopic mass | 482.25879342 Da |
|---|
| Source | PubChem · retrieved 2026-08-29 |
|---|
| InChIKey | RHRAMPXHWHSKQB-GGEUKFTFSA-N |
|---|
SMILES
C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N)N)O
InChI
InChI=1S/C19H38N4O10/c1-19(29)5-30-17(13(28)16(19)23-2)32-14-6(21)3-7(22)15(12(14)27)33-18-11(26)10(25)9(24)8(4-20)31-18/h6-18,23-29H,3-5,20-22H2,1-2H3/t6-,7+,8-,9-,10+,11-,12-,13-,14+,15-,16-,17-,18-,19+/m1/s1
Also called
- betamicin (EXACT_SYNONYM)— aro
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3000655 |
gentamicin B |
antibioticmech:aro-808cc3b683 |
2026-08-30 |
Molecular targets
The molecular entity or process this compound acts on. Each target
carries evidence — this is a mechanistic claim, not a classification.
antibiotic sensitive 16S rRNA NUCLEIC_ACID DIRECT_BINDING_TARGET
ARO:3000755
CARD/ARO database assertion; target organism, strain, and assay are not specified. 16S rRNA is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).
- ARO:3000755 (CARD/ARO asserts targeted_by_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
Resistance mechanisms
13 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_INACTIVATION 8
ANTIBIOTIC_INACTIVATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| APH(3')-IIIa |
ARO:3002647 |
not organism-specific |
— |
- ARO:3002647 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
| APH(3')-IIa |
ARO:3002644 |
not organism-specific |
— |
- ARO:3002644 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
| APH(3')-IIb |
ARO:3002645 |
not organism-specific |
— |
- ARO:3002645 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
| APH(3')-IIc |
ARO:3002646 |
not organism-specific |
— |
- ARO:3002646 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
| APH(3')-Ia |
ARO:3002641 |
not organism-specific |
— |
- ARO:3002641 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
| APH(3')-Ib |
ARO:3002642 |
not organism-specific |
— |
- ARO:3002642 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
| APH(3')-VIa |
ARO:3002652 |
not organism-specific |
— |
- ARO:3002652 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
| APH(3')-VIb |
ARO:3002653 |
not organism-specific |
— |
- ARO:3002653 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
ANTIBIOTIC_TARGET_ALTERATION 5
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| armA |
ARO:3000858 |
not organism-specific |
— |
- ARO:3000858 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
| rmtA |
ARO:3000859 |
not organism-specific |
— |
- ARO:3000859 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
| rmtB |
ARO:3000860 |
not organism-specific |
— |
- ARO:3000860 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
| rmtC |
ARO:3000861 |
not organism-specific |
— |
- ARO:3000861 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
| sgm |
ARO:3000862 |
not organism-specific |
— |
- ARO:3000862 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000655 (gentamicin B); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.