gentamicin C

antibioticmech:aro-6407ce57f1 ·ANTIBACTERIAL ·MINTED SEEDED

Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. — PMID:8385262

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

aminoglycoside antibioticARO:0000016

Strictly broader compounds or drug classes this molecule belongs to.

aminoglycoside antibiotic ARO:0000016

Chemical structure

Computed structure properties
Molecular formula	C19H39N5O7
Charge	0
Average mass	449.5 Da
Monoisotopic mass	449.2849486 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	VEGXETMJINRLTH-ALRICIOSSA-N

SMILES

C[C@@]1(CO[C@@H]([C@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@H]2O)O[C@@H]3[C@@H](CC[C@H](O3)CN)N)N)N)O

InChI

InChI=1S/C19H39N5O7/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h8-18,24-27H,3-7,20-23H2,1-2H3/t8-,9+,10-,11+,12+,13-,14+,15-,16+,17+,18+,19-/m0/s1

Also called

Cidomycin (EXACT_SYNONYM)— aro
Garamycin (EXACT_SYNONYM)— aro
Gentacycol (EXACT_SYNONYM)— aro
Gentamicins (EXACT_SYNONYM)— aro
Gentamycinum (EXACT_SYNONYM)— aro
Gentavet (EXACT_SYNONYM)— aro
Gentocin (EXACT_SYNONYM)— aro
Refobacin (EXACT_SYNONYM)— aro
Uromycine (EXACT_SYNONYM)— aro

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:0000014`	gentamicin C	`antibioticmech:aro-6407ce57f1`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive 16S rRNA NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000755

CARD/ARO database assertion; target organism, strain, and assay are not specified. 16S rRNA is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000755 (CARD/ARO asserts targeted_by_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)

Resistance mechanisms

14 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 9

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Borreliella burgdorferi 16S rRNA mutation conferring resistance to gentamicin	ARO:3003504	not organism-specific	—	ARO:3003504 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to gentamicin C	ARO:3003396	not organism-specific	—	ARO:3003396 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
Mycobacteroides abscessus 16S rRNA mutation conferring resistance to gentamicin	ARO:3003240	not organism-specific	—	ARO:3003240 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
Mycobacteroides chelonae 16S rRNA mutation conferring resistance to gentamicin C	ARO:3003517	not organism-specific	—	ARO:3003517 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
armA	ARO:3000858	not organism-specific	—	ARO:3000858 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
rmtA	ARO:3000859	not organism-specific	—	ARO:3000859 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
rmtB	ARO:3000860	not organism-specific	—	ARO:3000860 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
rmtC	ARO:3000861	not organism-specific	—	ARO:3000861 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
sgm	ARO:3000862	not organism-specific	—	ARO:3000862 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)

ANTIBIOTIC_EFFLUX 5

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
Klebsiella pneumoniae KpnGH-TolC	ARO:3004598	not organism-specific	—	ARO:3004598 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
MexCD-OprJ	ARO:3000797	not organism-specific	—	ARO:3000797 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
MexXY-OprA	ARO:3003038	not organism-specific	—	ARO:3003038 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
MexXY-OprM	ARO:3003032	not organism-specific	—	ARO:3003032 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)
Pseudomonas aeruginosa emrE	ARO:3004038	not organism-specific	—	ARO:3004038 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000014 (gentamicin C); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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