hookerianamide J

CHEBI:66022 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A steroid alkaloid that is 5α-preg-16-ene substituted by a hydroxy group at position 4, a N,N-dimethylamino group at position 20 and a N-senecoylamino group at position 3 (the 3β,4β,20S stereoisomer). Isolated from Sarcococca hookeriana, it exhibits antileishmanial and antibacterial activities. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:140325
Label unavailable CHEBI:26767
Label unavailable CHEBI:35681
Label unavailable CHEBI:51751

Chemical structure

Computed structure properties
Molecular formula	C28H46N2O2
Charge	0
Average mass	442.688 Da
Monoisotopic mass	442.35593 Da
Source	ChEBI
InChIKey	UBWMSSICUOCSHT-BJHCZKLTSA-N

SMILES

[H][C@@]12CC[C@@]3([H])[C@@H](O)[C@@H](NC(=O)C=C(C)C)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C([C@H](C)N(C)C)=CC[C@@]21[H]

InChI

InChI=1S/C28H46N2O2/c1-17(2)16-25(31)29-24-13-15-28(5)22-12-14-27(4)20(18(3)30(6)7)10-11-21(27)19(22)8-9-23(28)26(24)32/h10,16,18-19,21-24,26,32H,8-9,11-15H2,1-7H3,(H,29,31)/t18-,19-,21-,22-,23-,24-,26+,27+,28+/m0/s1

Also called

N-[(3β,4β,5α,20S)-20-(dimethylamino)-4-hydroxypregn-16-en-3-yl]-3-methylbut-2-enamide (EXACT_SYNONYM)— chebi
(20S)-20-(N,N-dimethylamino)-3β-(N-senecoylamino)-5α-preg-16-en-4β-ol (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

reaxys:18885924

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antibacterial agent CHEBI:33282
antileishmanial agent CHEBI:70868

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:66022`	hookerianamide J	`antibioticmech:chebi-6d644c5d3b`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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