hookerianamide K

CHEBI:66023 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A steroid alkaloid that is pregn-4,14-diene substituted by N-dimethylamino groups at positions 3 and 20 (the 3β,20S stereoisomer). Isolated from Sarcococca hookeriana, it exhibits antileishmanial and antibacterial activities. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:26767 CHEBI:26767
CHEBI:50996 CHEBI:50996

Chemical structure

Computed structure properties
Molecular formula	C25H42N2
Charge	0
Average mass	370.625 Da
Monoisotopic mass	370.3348 Da
Source	ChEBI
InChIKey	JLDLXPZTQHZTBT-JYNQZMPESA-N

SMILES

[H][C@]12CC[C@@]3(C)C(=CC[C@]3([H])[C@H](C)N(C)C)[C@]1([H])CCC1=C[C@@H](N(C)C)CC[C@@]12C

InChI

InChI=1S/C25H42N2/c1-17(26(4)5)21-10-11-22-20-9-8-18-16-19(27(6)7)12-14-24(18,2)23(20)13-15-25(21,22)3/h11,16-17,19-21,23H,8-10,12-15H2,1-7H3/t17-,19-,20-,21+,23-,24-,25+/m0/s1

Also called

(3β,20S)-N3,N3,N20,N20-tetramethylpregna-4,14-diene-3,20-diamine (EXACT_SYNONYM)— chebi
(20S)-20-(N-dimethylamino)-3β-(N-dimethylamino)-pregn-4,14-diene (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

reaxys:18885919

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33282 CHEBI:33282
CHEBI:70868 CHEBI:70868

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:66023`	hookerianamide K	`antibioticmech:chebi-c5b65cd77c`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.