hygromycin A
CHEBI:69414
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
Hygromycin A is an antibiotic produced by Streptomyces hygroscopicus. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site. Not to confused with Hygromycin B, which is structurally distinct. — PMID:26028538
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
antibiotic without defined classificationARO:3000003
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C23H29NO12 |
|---|
| Charge | 0 |
|---|
| Average mass | 511.48 Da |
|---|
| Monoisotopic mass | 511.16898 Da |
|---|
| Source | ChEBI |
|---|
| InChIKey | YQYJSBFKSSDGFO-IIHALWDASA-N |
|---|
SMILES
[H][C@@]12OCO[C@]1([H])[C@H](O)[C@@H](O)[C@@H](NC(=O)/C(C)=C/c1ccc(O[C@@H]3O[C@]([H])(C(C)=O)[C@@H](O)[C@@H]3O)c(O)c1)[C@H]2O
InChI
InChI=1S/C23H29NO12/c1-8(22(32)24-13-14(27)16(29)21-20(15(13)28)33-7-34-21)5-10-3-4-12(11(26)6-10)35-23-18(31)17(30)19(36-23)9(2)25/h3-6,13-21,23,26-31H,7H2,1-2H3,(H,24,32)/b8-5+/t13-,14+,15-,16-,17+,18+,19-,20+,21-,23-/m1/s1
Also called
- totomycin (EXACT_SYNONYM)— aro
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3007638 |
hygromycin A |
antibioticmech:aro-0887083165 |
2026-08-30 |
Resistance mechanisms
3 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_PROTECTION 3
ANTIBIOTIC_TARGET_PROTECTION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Clostridium sporogenes cplR |
ARO:3007645 |
not organism-specific |
— |
- ARO:3007645 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007638 (hygromycin A); database assertion, not a primary citation.)
|
| Neobacillus vireti vmlR2 |
ARO:3007646 |
not organism-specific |
— |
- ARO:3007646 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007638 (hygromycin A); database assertion, not a primary citation.)
|
| vmlR |
ARO:3004476 |
not organism-specific |
— |
- ARO:3004476 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007638 (hygromycin A); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.