iboxamycin
antibioticmech:aro-6d3a6e6b69
·ANTIBACTERIAL
·MINTED
SEEDED
Iboxamycin is a fully synthetic lincosamide antibiotic. Like other lincosamides, it selectively targets the bacterial ribosome and prevents elongation of the peptide chain. Iboxamycin has been shown to be effective against bacterial strains otherwise resistant to licosamide antibiotics. — PMID:34707295
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
lincosamide antibioticARO:0000017
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C22H39ClN2O6S |
|---|
| Charge | 0 |
|---|
| Average mass | 495.1 Da |
|---|
| Monoisotopic mass | 494.2217358 Da |
|---|
| Source | PubChem · retrieved 2026-08-29 |
|---|
| InChIKey | JPCLUJPDWMBCAA-SUTQZAMLSA-N |
|---|
SMILES
C[C@@H]([C@H]([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)SC)O)O)O)NC(=O)[C@@H]2[C@H]3[C@@H](C[C@@H](CCO3)CC(C)C)CN2)Cl
InChI
InChI=1S/C22H39ClN2O6S/c1-10(2)7-12-5-6-30-19-13(8-12)9-24-15(19)21(29)25-14(11(3)23)20-17(27)16(26)18(28)22(31-20)32-4/h10-20,22,24,26-28H,5-9H2,1-4H3,(H,25,29)/t11-,12-,13-,14+,15-,16-,17+,18+,19+,20+,22+/m0/s1
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3007636 |
iboxamycin |
antibioticmech:aro-6d3a6e6b69 |
2026-08-30 |
Resistance mechanisms
5 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_PROTECTION 5
ANTIBIOTIC_TARGET_PROTECTION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Clostridioides difficile cplR |
ARO:3007637 |
not organism-specific |
— |
- ARO:3007637 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007636 (iboxamycin); database assertion, not a primary citation.)
|
| Clostridium perfringes cplR |
ARO:3007644 |
not organism-specific |
— |
- ARO:3007644 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007636 (iboxamycin); database assertion, not a primary citation.)
|
| Clostridium sporogenes cplR |
ARO:3007645 |
not organism-specific |
— |
- ARO:3007645 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007636 (iboxamycin); database assertion, not a primary citation.)
|
| Neobacillus vireti vmlR2 |
ARO:3007646 |
not organism-specific |
— |
- ARO:3007646 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007636 (iboxamycin); database assertion, not a primary citation.)
|
| vmlR |
ARO:3004476 |
not organism-specific |
— |
- ARO:3004476 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007636 (iboxamycin); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.