iboxamycin

antibioticmech:aro-6d3a6e6b69 ·ANTIBACTERIAL ·MINTED SEEDED

Iboxamycin is a fully synthetic lincosamide antibiotic. Like other lincosamides, it selectively targets the bacterial ribosome and prevents elongation of the peptide chain. Iboxamycin has been shown to be effective against bacterial strains otherwise resistant to licosamide antibiotics. — PMID:34707295

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

lincosamide antibioticARO:0000017

Strictly broader compounds or drug classes this molecule belongs to.

lincosamide antibiotic ARO:0000017

Chemical structure

Computed structure properties
Molecular formula	C22H39ClN2O6S
Charge	0
Average mass	495.1 Da
Monoisotopic mass	494.2217358 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	JPCLUJPDWMBCAA-SUTQZAMLSA-N

SMILES

C[C@@H]([C@H]([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)SC)O)O)O)NC(=O)[C@@H]2[C@H]3[C@@H](C[C@@H](CCO3)CC(C)C)CN2)Cl

InChI

InChI=1S/C22H39ClN2O6S/c1-10(2)7-12-5-6-30-19-13(8-12)9-24-15(19)21(29)25-14(11(3)23)20-17(27)16(26)18(28)22(31-20)32-4/h10-20,22,24,26-28H,5-9H2,1-4H3,(H,25,29)/t11-,12-,13-,14+,15-,16-,17+,18+,19+,20+,22+/m0/s1

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

iboxamycinARO:3007636
pubchem.compound:156613433

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3007636`	iboxamycin	`antibioticmech:aro-6d3a6e6b69`	2026-08-30

Resistance mechanisms

5 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_PROTECTION 5

ANTIBIOTIC_TARGET_PROTECTION
Determinant	ARO ID	Organism	Gene families	Evidence
Clostridioides difficile cplR	ARO:3007637	not organism-specific	—	ARO:3007637 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007636 (iboxamycin); database assertion, not a primary citation.)
Clostridium perfringes cplR	ARO:3007644	not organism-specific	—	ARO:3007644 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007636 (iboxamycin); database assertion, not a primary citation.)
Clostridium sporogenes cplR	ARO:3007645	not organism-specific	—	ARO:3007645 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007636 (iboxamycin); database assertion, not a primary citation.)
Neobacillus vireti vmlR2	ARO:3007646	not organism-specific	—	ARO:3007646 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007636 (iboxamycin); database assertion, not a primary citation.)
vmlR	ARO:3004476	not organism-specific	—	ARO:3004476 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007636 (iboxamycin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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