klebsazolicin

antibioticmech:aro-2b2f71621c ·ANTIBACTERIAL ·MINTED SEEDED

Klebsazolicin is a peptide antibiotic encoded by and identified from the genome of Klebsiella pneumoniae. Klebsazolicin is a ribosomally synthesized and post-translationally modified peptide with antibiotic activity against gram-negative bacteria. Klebsazolicin inhibits ribosomal protein synthesis through binding and thus blocking peptide access. — PMID:28846667

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

ribosomally synthesized and post-translationally modified peptide antibioticsARO:3009656

Strictly broader compounds or drug classes this molecule belongs to.

ARO:3009656 ARO:3009656

Chemical structure

Computed structure properties
Molecular formula	C76H107N27O30S3
Charge	0
Average mass	1975.0 Da
Monoisotopic mass	1973.6839286 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	RSVIJELKMXTPMI-CKSXXEILSA-N

SMILES

C[C@H]([C@@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O)NC(=O)C1=CSC(=N1)[C@H](CC(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)C2=COC(=N2)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)C3=CSC(=N3)[C@H](CO)NC(=O)[C@H](C)NC(=O)C4=CSC(=N4)[C@H](CC(=O)N)NC(=O)CNC(=O)C5CCCN5C(=O)[C@H](CO)NC6=N[C@H](C(=O)N[C@H]6CCC(=O)N)CO)O

InChI

InChI=1S/C76H107N27O30S3/c1-29(2)12-35(62(122)84-19-56(117)118)88-54(115)17-81-53(114)16-83-71(131)57(33(6)109)102-69(129)47-28-135-74(100-47)38(15-52(80)113)94-59(119)30(3)85-63(123)40(21-105)95-60(120)31(4)86-66(126)44-25-133-72(98-44)36(13-50(78)111)93-65(125)41(22-106)96-68(128)46-27-136-75(101-46)42(23-107)97-61(121)32(5)87-67(127)45-26-134-73(99-45)37(14-51(79)112)89-55(116)18-82-70(130)48-8-7-11-103(48)76(132)43(24-108)91-58-34(9-10-49(77)110)92-64(124)39(20-104)90-58/h25-43,48,57,104-109H,7-24H2,1-6H3,(H2,77,110)(H2,78,111)(H2,79,112)(H2,80,113)(H,81,114)(H,82,130)(H,83,131)(H,84,122)(H,85,123)(H,86,126)(H,87,127)(H,88,115)(H,89,116)(H,90,91)(H,92,124)(H,93,125)(H,94,119)(H,95,120)(H,96,128)(H,97,121)(H,102,129)(H,117,118)/t30-,31-,32-,33+,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,48?,57-/m0/s1

Also called

KLB (EXACT_SYNONYM)— aro

Cross-references

Equivalent identifiers for this same structure in other resources.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3009315`	klebsazolicin	`antibioticmech:aro-2b2f71621c`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.