lincomycin

CHEBI:6472 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

lincosamide antibioticARO:0000017

Strictly broader compounds or drug classes this molecule belongs to.

carbohydrate-containing antibiotic CHEBI:23007
Label unavailable CHEBI:29347
Label unavailable CHEBI:35275
Label unavailable CHEBI:46770
Label unavailable CHEBI:84186
lincosamide antibiotic ARO:0000017

Chemical structure

Computed structure properties
Molecular formula	C18H34N2O6S
Charge	0
Average mass	406.545 Da
Monoisotopic mass	406.21376 Da
Source	ChEBI
InChIKey	OJMMVQQUTAEWLP-KIDUDLJLSA-N

SMILES

[H][C@@]1(C(=O)N[C@@H]([C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](C)O)C[C@@H](CCC)CN1C

InChI

InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1

Also called

lincomicina (INN)— chebi
lincomycine (INN)— chebi
lincomycinum (INN)— chebi
methyl 6,8-dideoxy-6-({[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]carbonyl}amino)-1-thio-D-erythro-α-D-galacto-octopyranoside (EXACT_SYNONYM)— chebi
Cillimycin (EXACT_SYNONYM)— chebi
Lincomycin (EXACT_SYNONYM)— chebi
Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galacto-octopyranoside (EXACT_SYNONYM)— chebi
Epilincomycin (EXACT_SYNONYM)— aro
Jiemycin (EXACT_SYNONYM)— aro
Lincocin (EXACT_SYNONYM)— aro
Lincolcina (EXACT_SYNONYM)— aro
Lincolnensin (EXACT_SYNONYM)— aro
Lincomicina (EXACT_SYNONYM)— aro
Lincomycin A (EXACT_SYNONYM)— aro
Lincomycine (EXACT_SYNONYM)— aro
Lincomycinum (EXACT_SYNONYM)— aro

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

wikipedia.en:Lincomycin

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antimicrobial agent CHEBI:33281

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:0000046`	lincomycin	`antibioticmech:aro-0716d7a82f`	2026-08-30
CHEBI	`CHEBI:6472`	lincomycin	`antibioticmech:chebi-451b500d4d`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive peptidyl transferase (23S rRNA) NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000754

CARD/ARO database assertion; target organism, strain, and assay are not specified. 23S rRNA peptidyl-transferase center is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000754 (CARD/ARO asserts targeted_by_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)

Resistance mechanisms

60 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 31

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Erm(33)	ARO:3000599	not organism-specific	—	ARO:3000599 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
Erm(34)	ARO:3000600	not organism-specific	—	ARO:3000600 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
Erm(35)	ARO:3000604	not organism-specific	—	ARO:3000604 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
Erm(36)	ARO:3000605	not organism-specific	—	ARO:3000605 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
Erm(37)	ARO:3000392	not organism-specific	—	ARO:3000392 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
Erm(38)	ARO:3000601	not organism-specific	—	ARO:3000601 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
Erm(39)	ARO:3000602	not organism-specific	—	ARO:3000602 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
Erm(41)	ARO:3000603	not organism-specific	—	ARO:3000603 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
Erm(47)	ARO:3003908	not organism-specific	—	ARO:3003908 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
Erm(O)-lrm	ARO:3004652	not organism-specific	—	ARO:3004652 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmA	ARO:3000347	not organism-specific	—	ARO:3000347 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmB	ARO:3000375	not organism-specific	—	ARO:3000375 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmC	ARO:3000250	not organism-specific	—	ARO:3000250 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmD	ARO:3000495	not organism-specific	—	ARO:3000495 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmE	ARO:3000326	not organism-specific	—	ARO:3000326 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmF	ARO:3000498	not organism-specific	—	ARO:3000498 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmG	ARO:3000522	not organism-specific	—	ARO:3000522 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmH	ARO:3002823	not organism-specific	—	ARO:3002823 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmN	ARO:3000592	not organism-specific	—	ARO:3000592 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmO-srmA	ARO:3001303	not organism-specific	—	ARO:3001303 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmQ	ARO:3000593	not organism-specific	—	ARO:3000593 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmR	ARO:3000594	not organism-specific	—	ARO:3000594 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmS	ARO:3001304	not organism-specific	—	ARO:3001304 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmT	ARO:3000595	not organism-specific	—	ARO:3000595 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmU	ARO:3001305	not organism-specific	—	ARO:3001305 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
ErmX	ARO:3000596	not organism-specific	—	ARO:3000596 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
cfrA	ARO:3003441	not organism-specific	—	ARO:3003441 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
cipA	ARO:3003907	not organism-specific	—	ARO:3003907 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
clbA	ARO:3002814	not organism-specific	—	ARO:3002814 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
clbB	ARO:3002815	not organism-specific	—	ARO:3002815 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
clbC	ARO:3002816	not organism-specific	—	ARO:3002816 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_PROTECTION 15

ANTIBIOTIC_TARGET_PROTECTION
Determinant	ARO ID	Organism	Gene families	Evidence
Clostridioides difficile cplR	ARO:3007637	not organism-specific	—	ARO:3007637 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
Clostridium perfringes cplR	ARO:3007644	not organism-specific	—	ARO:3007644 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lmrC	ARO:3002881	not organism-specific	—	ARO:3002881 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lsaC	ARO:3003112	not organism-specific	—	ARO:3003112 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lsaD	ARO:3005121	not organism-specific	—	ARO:3005121 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lsaE	ARO:3003206	not organism-specific	—	ARO:3003206 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
salA	ARO:3003749	not organism-specific	—	ARO:3003749 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
salB	ARO:3007026	not organism-specific	—	ARO:3007026 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
salC	ARO:3007027	not organism-specific	—	ARO:3007027 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
salD	ARO:3007028	not organism-specific	—	ARO:3007028 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
tlrC	ARO:3002827	not organism-specific	—	ARO:3002827 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
vga(E) Staphylococcus cohnii	ARO:3004715	not organism-specific	—	ARO:3004715 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
vgaALC	ARO:3002830	not organism-specific	—	ARO:3002830 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
vgaC	ARO:3002831	not organism-specific	—	ARO:3002831 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
vmlR	ARO:3004476	not organism-specific	—	ARO:3004476 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)

ANTIBIOTIC_INACTIVATION 11

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
LnuH	ARO:3004600	not organism-specific	—	ARO:3004600 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
LnuP	ARO:3004601	not organism-specific	—	ARO:3004601 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lin	ARO:3004651	not organism-specific	—	ARO:3004651 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
linG	ARO:3002879	not organism-specific	—	ARO:3002879 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lnuA	ARO:3002835	not organism-specific	—	ARO:3002835 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lnuB	ARO:3002836	not organism-specific	—	ARO:3002836 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lnuC	ARO:3002837	not organism-specific	—	ARO:3002837 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lnuD	ARO:3002838	not organism-specific	—	ARO:3002838 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lnuE	ARO:3003762	not organism-specific	—	ARO:3003762 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lnuF	ARO:3002839	not organism-specific	—	ARO:3002839 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lnuG	ARO:3004085	not organism-specific	—	ARO:3004085 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)

ANTIBIOTIC_EFFLUX 3

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
Mef(En2)	ARO:3004659	not organism-specific	—	ARO:3004659 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
lmrAB Operon	ARO:3003027	not organism-specific	—	ARO:3003027 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)
mdtM	ARO:3001214	not organism-specific	—	ARO:3001214 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000046 (lincomycin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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