AntibioticMech

LYS228

antibioticmech:aro-00a588048a ·ANTIBACTERIAL ·MINTED SEEDED

A monobactam with potent activity against Enterobacteriaceae. Stable to metallo-B-lactamases and serine carbapenemases resulting in potency against the majority of extended-spectrum B-lactamase-producing and carbapenem-resistant Enterobacteriaceae strains tested. — PMID:30038040

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

monobactamARO:0000004

Strictly broader compounds or drug classes this molecule belongs to.

Chemical structure

Computed structure properties
Molecular formulaC16H18N6O10S2
Charge0
Average mass518.5 Da
Monoisotopic mass518.05258314 Da
SourcePubChem · retrieved 2026-08-29
InChIKeyFWTGYTRQUBRVDW-UWGJAOEXSA-N

SMILES

C1CC1(C(=O)O)O/N=C(\C2=CSC(=N2)N)/C(=O)N[C@H]3[C@H](N(C3=O)S(=O)(=O)O)CN4CCOC4=O

InChI

InChI=1S/C16H18N6O10S2/c17-14-18-7(6-33-14)9(20-32-16(1-2-16)13(25)26)11(23)19-10-8(5-21-3-4-31-15(21)27)22(12(10)24)34(28,29)30/h6,8,10H,1-5H2,(H2,17,18)(H,19,23)(H,25,26)(H,28,29,30)/b20-9+/t8-,10+/m1/s1

Cross-references

Equivalent identifiers for this same structure in other resources.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
SourceNative IDLabelMinted CURIEVersion
ARO ARO:3004729 LYS228 antibioticmech:aro-00a588048a 2026-08-30

Curation history

  1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Seeded from data/raw/ inventories (ARO)

  2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.