madumycin II
antibioticmech:aro-59524d78a3
·ANTIBACTERIAL
·MINTED
SEEDED
Madumycin II is a streptogramin A antibiotic. — PMID:15700955
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
streptogramin antibioticARO:0000026
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C26H37N3O7 |
|---|
| Charge | 0 |
|---|
| Average mass | 503.6 Da |
|---|
| Monoisotopic mass | 503.26315053 Da |
|---|
| Source | PubChem · retrieved 2026-08-29 |
|---|
| InChIKey | SAQNYTQFLPVTNJ-PPIFFTIDSA-N |
|---|
SMILES
C[C@@H]1/C=C/C(=O)NC/C=C/C(=C/[C@H](C[C@H](CC2=NC(=CO2)C(=O)N[C@@H](C(=O)O[C@@H]1C(C)C)C)O)O)/C
InChI
InChI=1S/C26H37N3O7/c1-15(2)24-17(4)8-9-22(32)27-10-6-7-16(3)11-19(30)12-20(31)13-23-29-21(14-35-23)25(33)28-18(5)26(34)36-24/h6-9,11,14-15,17-20,24,30-31H,10,12-13H2,1-5H3,(H,27,32)(H,28,33)/b7-6+,9-8+,16-11+/t17-,18-,19-,20-,24-/m1/s1
Also called
- A2315A (EXACT_SYNONYM)— aro
- madumicin II (EXACT_SYNONYM)— aro
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3000672 |
madumycin II |
antibioticmech:aro-59524d78a3 |
2026-08-30 |
Molecular targets
The molecular entity or process this compound acts on. Each target
carries evidence — this is a mechanistic claim, not a classification.
antibiotic sensitive peptidyl transferase (23S rRNA) NUCLEIC_ACID DIRECT_BINDING_TARGET
ARO:3000754
CARD/ARO database assertion; target organism, strain, and assay are not specified. 23S rRNA peptidyl-transferase center is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).
- ARO:3000754 (CARD/ARO asserts targeted_by_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
Resistance mechanisms
26 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_ALTERATION 25
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Erm(33) |
ARO:3000599 |
not organism-specific |
— |
- ARO:3000599 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| Erm(34) |
ARO:3000600 |
not organism-specific |
— |
- ARO:3000600 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| Erm(35) |
ARO:3000604 |
not organism-specific |
— |
- ARO:3000604 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| Erm(36) |
ARO:3000605 |
not organism-specific |
— |
- ARO:3000605 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| Erm(37) |
ARO:3000392 |
not organism-specific |
— |
- ARO:3000392 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| Erm(38) |
ARO:3000601 |
not organism-specific |
— |
- ARO:3000601 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| Erm(39) |
ARO:3000602 |
not organism-specific |
— |
- ARO:3000602 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| Erm(41) |
ARO:3000603 |
not organism-specific |
— |
- ARO:3000603 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmA |
ARO:3000347 |
not organism-specific |
— |
- ARO:3000347 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmB |
ARO:3000375 |
not organism-specific |
— |
- ARO:3000375 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmC |
ARO:3000250 |
not organism-specific |
— |
- ARO:3000250 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmD |
ARO:3000495 |
not organism-specific |
— |
- ARO:3000495 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmE |
ARO:3000326 |
not organism-specific |
— |
- ARO:3000326 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmF |
ARO:3000498 |
not organism-specific |
— |
- ARO:3000498 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmG |
ARO:3000522 |
not organism-specific |
— |
- ARO:3000522 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmN |
ARO:3000592 |
not organism-specific |
— |
- ARO:3000592 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmQ |
ARO:3000593 |
not organism-specific |
— |
- ARO:3000593 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmR |
ARO:3000594 |
not organism-specific |
— |
- ARO:3000594 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmT |
ARO:3000595 |
not organism-specific |
— |
- ARO:3000595 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| ErmX |
ARO:3000596 |
not organism-specific |
— |
- ARO:3000596 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| cfrA |
ARO:3003441 |
not organism-specific |
— |
- ARO:3003441 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| cipA |
ARO:3003907 |
not organism-specific |
— |
- ARO:3003907 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| clbA |
ARO:3002814 |
not organism-specific |
— |
- ARO:3002814 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| clbB |
ARO:3002815 |
not organism-specific |
— |
- ARO:3002815 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
| clbC |
ARO:3002816 |
not organism-specific |
— |
- ARO:3002816 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
ANTIBIOTIC_INACTIVATION 1
ANTIBIOTIC_INACTIVATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| streptogramin vat acetyltransferase |
ARO:3000453 |
not organism-specific |
— |
- ARO:3000453 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000672 (madumycin II); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.