methymycin

CHEBI:29630 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A twelve-membered macrolide antibiotic that is biosynthesised by Streptomyces venezuelae. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

macrolide antibioticARO:0000000

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:25105 CHEBI:25105
CHEBI:51689 CHEBI:51689
CHEBI:63367 CHEBI:63367
ARO:0000000 ARO:0000000

Chemical structure

Computed structure properties
Molecular formula	C25H43NO7
Charge	0
Average mass	469.619 Da
Monoisotopic mass	469.30395 Da
Source	ChEBI
InChIKey	HUKYPYXOBINMND-HYUJHOPRSA-N

SMILES

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/[C@]1(C)O

InChI

InChI=1S/C25H43NO7/c1-9-20-25(6,30)11-10-19(27)14(2)12-15(3)22(17(5)23(29)32-20)33-24-21(28)18(26(7)8)13-16(4)31-24/h10-11,14-18,20-22,24,28,30H,9,12-13H2,1-8H3/b11-10+/t14-,15+,16-,17-,18+,20-,21-,22+,24+,25+/m1/s1

Also called

(3R,4S,5S,7R,9E,11S,12R)-12-ethyl-11-hydroxy-3,5,7,11-tetramethyl-2,8-dioxooxacyclododec-9-en-4-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3001232
cas:497-72-3
kegg.compound:C11996
lipidmaps:LMPK04000037
metacyc.compound:CPD-13832
patent:EP1090125
patent:US2003073824
patent:WO0000620
pdb-ccd:MT9
reaxys:61348
chembl:CHEMBL489347
pubchem.compound:5282034

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3001232`	methymycin	`antibioticmech:aro-4ba2ddc2c0`	2026-08-30
CHEBI	`CHEBI:29630`	methymycin	`antibioticmech:chebi-f576ea5607`	2026-08-30

Resistance mechanisms

5 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 3

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Erm(30)	ARO:3001265	not organism-specific	—	ARO:3001265 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001232 (methymycin); database assertion, not a primary citation.)
Erm(31)	ARO:3000598	not organism-specific	—	ARO:3000598 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001232 (methymycin); database assertion, not a primary citation.)
erm(32)	ARO:3004592	not organism-specific	—	ARO:3004592 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001232 (methymycin); database assertion, not a primary citation.)

ANTIBIOTIC_INACTIVATION 2

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
gimA	ARO:3000463	not organism-specific	—	ARO:3000463 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001232 (methymycin); database assertion, not a primary citation.)
mgtA	ARO:3000462	not organism-specific	—	ARO:3000462 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001232 (methymycin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.