minocycline

CHEBI:50694 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

tetracycline antibioticARO:3000050

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:139592 CHEBI:139592
CHEBI:26895 CHEBI:26895
CHEBI:48132 CHEBI:48132
ARO:3000050 ARO:3000050

Chemical structure

Computed structure properties
Molecular formula	C23H27N3O7
Charge	0
Average mass	457.483 Da
Monoisotopic mass	457.1849 Da
Source	ChEBI
InChIKey	DYKFCLLONBREIL-KVUCHLLUSA-N

SMILES

[H][C@@]12Cc3c(N(C)C)ccc(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2

InChI

InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1

Also called

minociclina (INN)— chebi
minociclinum (INN)— chebi
(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (EXACT_SYNONYM)— chebi
(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE (EXACT_SYNONYM)— chebi
7-Dimethylamino-6-demethyl-6-deoxytetracycline (EXACT_SYNONYM)— chebi
Minocycline (EXACT_SYNONYM)— chebi
minomycin (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3000152
cas:10118-90-8
chemspider:16735907
drugbank:DB01017
drugcentral:1813
hmdb:HMDB0015152
kegg.compound:C07225
kegg.drug:D05045
knapsack:C00018686
lipidmaps:LMPK07000002
patent:US3226436
patent:WO2008104734
pdb-ccd:MIY
reaxys:3077644
chembl:CHEMBL1434
pubchem.compound:54675783

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281
CHEBI:36047 CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3000152`	minocycline	`antibioticmech:aro-62156c8089`	2026-08-30
CHEBI	`CHEBI:50694`	minocycline	`antibioticmech:chebi-305a19e931`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive 16S rRNA NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000755

CARD/ARO database assertion; target organism, strain, and assay are not specified. 16S rRNA is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000755 (CARD/ARO asserts targeted_by_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)

Resistance mechanisms

19 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_PROTECTION 12

ANTIBIOTIC_TARGET_PROTECTION
Determinant	ARO ID	Organism	Gene families	Evidence
tet(32)	ARO:3000196	not organism-specific	—	ARO:3000196 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(36)	ARO:3000197	not organism-specific	—	ARO:3000197 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(44)	ARO:3000556	not organism-specific	—	ARO:3000556 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(61)	ARO:3004576	not organism-specific	—	ARO:3004576 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(M)	ARO:3000186	not organism-specific	—	ARO:3000186 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(O)	ARO:3000190	not organism-specific	—	ARO:3000190 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(Q)	ARO:3000191	not organism-specific	—	ARO:3000191 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(S)	ARO:3000192	not organism-specific	—	ARO:3000192 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(T)	ARO:3000193	not organism-specific	—	ARO:3000193 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(W)	ARO:3000194	not organism-specific	—	ARO:3000194 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(W/N/W)	ARO:3004442	not organism-specific	—	ARO:3004442 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tetB(P)	ARO:3000195	not organism-specific	—	ARO:3000195 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)

ANTIBIOTIC_INACTIVATION 6

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
tet(53)	ARO:3004589	not organism-specific	—	ARO:3004589 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(55)	ARO:3004591	not organism-specific	—	ARO:3004591 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(X)	ARO:3000205	not organism-specific	—	ARO:3000205 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(X1)	ARO:3005166	not organism-specific	—	ARO:3005166 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(X5)	ARO:3005057	not organism-specific	—	ARO:3005057 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)
tet(X6)	ARO:3005056	not organism-specific	—	ARO:3005056 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)

ANTIBIOTIC_EFFLUX 1

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
lmrP	ARO:3003969	not organism-specific	—	ARO:3003969 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.