minocycline

CHEBI:50694 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5. — ChEBI

Classification

tetracycline antibioticARO:3000050

Strictly broader compounds or drug classes this molecule belongs to.

• Label unavailable CHEBI:139592
• Label unavailable CHEBI:26895
• tetracenomycin CHEBI:48132
• tetracycline antibiotic ARO:3000050

Chemical structure

SMILES

[H][C@@]12Cc3c(N(C)C)ccc(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2

InChI

InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1

Also called

• minociclina (INN)— chebi
• minociclinum (INN)— chebi
• (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (EXACT_SYNONYM)— chebi
• (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE (EXACT_SYNONYM)— chebi
• 7-Dimethylamino-6-demethyl-6-deoxytetracycline (EXACT_SYNONYM)— chebi
• Minocycline (EXACT_SYNONYM)— chebi
• minomycin (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

• minocyclineARO:3000152
• cas:10118-90-8
• chemspider:16735907
• hmdb:HMDB0015152
• kegg.compound:C07225
• knapsack:C00018686
• lipidmaps:LMPK07000002
• pdb-ccd:MIY
• reaxys:3077644
• chembl:CHEMBL1434
• pubchem.compound:54675783

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

• drugbank:DB01017
• drugcentral:1813
• kegg.drug:D05045

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

• patent:US3226436
• patent:WO2008104734

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• antimicrobial agent CHEBI:33281
• antibacterial drug CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive 16S rRNA NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000755

CARD/ARO database assertion; target organism, strain, and assay are not specified. 16S rRNA is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

• ARO:3000755 (CARD/ARO asserts targeted_by_antibiotic ARO:3000152 (minocycline); database assertion, not a primary citation.)

Activity spectrum

Measured or curated activity against specific taxa. A number without a method is not an observation — every row here carries an assay.

10 observations · Browse all observations · Complete record (JSON.gz)

Resistance mechanisms

19 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO, CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

6. CURATED_RESISTANT_TAXA 2026-09-12 · codex · LLM-assisted

   Added one stable-URL CDC/FDA AR Isolate Bank minocycline-resistant Klebsiella pneumoniae isolate MIC observation.

7. CURATED_RESISTANT_TAXA 2026-09-12 · codex · LLM-assisted

   Added one stable-URL CDC/FDA AR Isolate Bank minocycline-resistant Acinetobacter baumannii isolate MIC observation.

8. CURATED_RESISTANT_TAXA 2026-09-12 · codex · LLM-assisted

   Added one stable-URL CDC/FDA AR Isolate Bank minocycline-resistant Escherichia coli isolate MIC observation for AR-1305.

9. CURATED_RESISTANT_TAXA 2026-09-13 · codex · LLM-assisted

   Added 6 stable-URL CDC/FDA AR Isolate Bank minocycline-resistant Multi-Mechanism panel MIC observations for AR-1149, AR-1151, AR-1152, AR-1153, AR-1162, and AR-1163.

10. CURATED_RESISTANT_TAXA 2026-09-19 · codex · LLM-assisted

    Added one stable-URL CDC/FDA AR Isolate Bank Panel 1227 minocycline-resistant Acinetobacter baumannii MIC observation for AR-0083; preserved source Unknown, BioSample SAMN04014924, Study ID CarbaNP-52, and MLST ST1(Pasteur)/ST231/1604(Oxford) in evidence notes.

11. STRUCTURED_ACTIVITY_BIOSAMPLE_ACCESSIONS 2026-09-26 · codex · LLM-assisted

    Structured BioSample accessions on 10 activity_spectrum observation(s) where evidence notes already named exactly one accession.

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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