moxifloxacin

CHEBI:63611 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

fluoroquinolone antibioticARO:0000001

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:23765 CHEBI:23765
CHEBI:26512 CHEBI:26512
CHEBI:35618 CHEBI:35618
CHEBI:51454 CHEBI:51454
CHEBI:63697 CHEBI:63697
CHEBI:86324 CHEBI:86324
CHEBI:87211 CHEBI:87211
ARO:0000001 ARO:0000001

Chemical structure

Computed structure properties
Molecular formula	C21H24FN3O4
Charge	0
Average mass	401.438 Da
Monoisotopic mass	401.17508 Da
Source	ChEBI
InChIKey	FABPRXSRWADJSP-MEDUHNTESA-N

SMILES

[H][C@@]12CCCN[C@]1([H])CN(c1c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c1OC)C2

InChI

InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1

Also called

1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (EXACT_SYNONYM)— chebi
1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid (EXACT_SYNONYM)— chebi
Moxifloxacin (EXACT_SYNONYM)— chebi
Actira (hydrochloride) (EXACT_SYNONYM)— aro
Avelox (hydrochloride) (EXACT_SYNONYM)— aro
Avelox (EXACT_SYNONYM)— aro
MXFX (EXACT_SYNONYM)— aro
Moxifloxacin hydrochloride (EXACT_SYNONYM)— aro
Vigamox (EXACT_SYNONYM)— aro

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:0000074
cas:151096-09-2
drugbank:DB00218
drugcentral:1854
kegg.compound:C07663
kegg.drug:D08237
lincs.smallmolecule:LSM-5746
patent:EP550903
reaxys:8365827
vsdb:2983
wikipedia.en:Moxifloxacin
chembl:CHEMBL32
pubchem.compound:152946

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281
CHEBI:36047 CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:0000074`	moxifloxacin	`antibioticmech:aro-d4dcbaef43`	2026-08-30
CHEBI	`CHEBI:63611`	moxifloxacin	`antibioticmech:chebi-5148253f79`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

fluoroquinolone sensitive gyrA PROTEIN DIRECT_BINDING_TARGET

ARO:3000733

CARD/ARO database assertion; target organism, strain, and assay are not specified. ARO explicitly describes ligand binding to gyrase subunit A. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000733 (CARD/ARO asserts targeted_by_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)

Resistance mechanisms

31 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 28

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Acinetobacter baumannii gyrA conferring resistance to fluoroquinolones	ARO:3003817	not organism-specific	—	ARO:3003817 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Acinetobacter baumannii parC conferring resistance to fluoroquinolones	ARO:3003818	not organism-specific	—	ARO:3003818 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones	ARO:3003297	not organism-specific	—	ARO:3003297 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Clostridioides difficile gyrA conferring resistance to fluoroquinolones	ARO:3003995	not organism-specific	—	ARO:3003995 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Clostridioides difficile gyrB conferring resistance to fluoroquinolones	ARO:3004562	not organism-specific	—	ARO:3004562 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Escherichia coli gyrA conferring resistance to fluoroquinolones	ARO:3003294	not organism-specific	—	ARO:3003294 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Escherichia coli parC conferring resistance to fluoroquinolones	ARO:3003308	not organism-specific	—	ARO:3003308 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Escherichia coli parE conferring resistance to fluoroquinolones	ARO:3003316	not organism-specific	—	ARO:3003316 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Morganella morganii gyrB conferring resistance to fluoroquinolones	ARO:3003306	not organism-specific	—	ARO:3003306 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Mycobacterium avium gyrA with mutation conferring resistance to fluoroquinolone	ARO:3007473	not organism-specific	—	ARO:3007473 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Mycobacterium leprae gyrA conferring resistance to fluoroquinolones	ARO:3003298	not organism-specific	—	ARO:3003298 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Mycobacterium leprae gyrB conferring resistance to fluoroquinolones	ARO:3003304	not organism-specific	—	ARO:3003304 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Mycobacterium tuberculosis eccC5 conferring resistance to fluoroquinolones	ARO:3004919	not organism-specific	—	ARO:3004919 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones	ARO:3003295	not organism-specific	—	ARO:3003295 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Mycobacterium tuberculosis gyrA mutations conferring resistance to moxifloxacin	ARO:3007806	not organism-specific	—	ARO:3007806 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Mycobacterium tuberculosis gyrB with mutation conferring resistance to fluoroquinolones	ARO:3003459	not organism-specific	—	ARO:3003459 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Mycoplasma genitalium 23S rRNA mutations confers resistance to fluoroquinolone and macrolide antibiotics	ARO:3004616	not organism-specific	—	ARO:3004616 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Mycoplasma genitalium gyrA mutation confers resistance to fluoroquinolones	ARO:3004631	not organism-specific	—	ARO:3004631 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Mycoplasma genitalium parC mutations confers resistance to Moxifloxacin	ARO:3004630	not organism-specific	—	ARO:3004630 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Mycoplasma hominis parC conferring resistance to fluoroquinolones	ARO:3003310	not organism-specific	—	ARO:3003310 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Salmonella serovars gyrB conferring resistance to fluoroquinolones	ARO:3003307	not organism-specific	—	ARO:3003307 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Salmonella serovars parE conferring resistance to fluoroquinolones	ARO:3003317	not organism-specific	—	ARO:3003317 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Staphylococcus aureus gyrA conferring resistance to fluoroquinolones	ARO:3003296	not organism-specific	—	ARO:3003296 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Staphylococcus aureus parC conferring resistance to fluoroquinolones	ARO:3003312	not organism-specific	—	ARO:3003312 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Staphylococcus aureus parE conferring resistance to fluoroquinolones	ARO:3003315	not organism-specific	—	ARO:3003315 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Streptococcus pneumoniae parC conferring resistance to fluoroquinolones	ARO:3003311	not organism-specific	—	ARO:3003311 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones	ARO:3003305	not organism-specific	—	ARO:3003305 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
Ureaplasma urealyticum parC conferring resistance to fluoroquinolones	ARO:3003309	not organism-specific	—	ARO:3003309 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)

ANTIBIOTIC_EFFLUX 2

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
QepA2	ARO:3004103	not organism-specific	—	ARO:3004103 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)
norB	ARO:3000421	not organism-specific	—	ARO:3000421 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_PROTECTION 1

ANTIBIOTIC_TARGET_PROTECTION
Determinant	ARO ID	Organism	Gene families	Evidence
quinolone resistance protein (qnr)	ARO:3000419	not organism-specific	—	ARO:3000419 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000074 (moxifloxacin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.