NSC348884

antibioticmech:curator-8e9e4cae3e ·ANTIBACTERIAL ·MINTED PROPOSED

A benzimidazole analogue with antibacterial activity against carbapenem-resistant Gram-negative bacteria. — DOI:10.1016/j.bcp.2026.117910

Chemical structure

Computed structure properties
Molecular formula	C38H40N10
Charge	0
Average mass	636.8 Da
Monoisotopic mass	636.34374132 Da
Source	https://pubchem.ncbi.nlm.nih.gov/compound/335974 · retrieved 2026-09-08
InChIKey	KZOLQEUQAFTQFM-UHFFFAOYSA-N

SMILES

CC1=CC2=C(C=C1)N=C(N2)CN(CCN(CC3=NC4=C(N3)C=C(C=C4)C)CC5=NC6=C(N5)C=C(C=C6)C)CC7=NC8=C(N7)C=C(C=C8)C

InChI

InChI=1S/C38H40N10/c1-23-5-9-27-31(15-23)43-35(39-27)19-47(20-36-40-28-10-6-24(2)16-32(28)44-36)13-14-48(21-37-41-29-11-7-25(3)17-33(29)45-37)22-38-42-30-12-8-26(4)18-34(30)46-38/h5-12,15-18H,13-14,19-22H2,1-4H3,(H,39,43)(H,40,44)(H,41,45)(H,42,46)

Also called

NSC 348884 (EXACT_SYNONYM)— curator
NSC-348884 (EXACT_SYNONYM)— curator

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

pubchem.compound:335974

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antibacterial agent CHEBI:33282

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version	Evidence
CURATOR	`DOI:10.1016/j.bcp.2026.117910#nsc348884`	NSC348884	`antibioticmech:curator-8e9e4cae3e`	2026-09-08	DOI:10.1016/j.bcp.2026.117910 — "Zhang et al. identified NSC348884 as a benzimidazole analogue with direct antibacterial activity against carbapenem-resistant Acinetobacter baumannii, reported anti-biofilm activity, and measured reduced blood bacterial load in a mouse systemic infection model." (PubChem CID 335974 supplies the standard InChI, InChIKey, formula, and SMILES for NSC348884.)

Curation history

PROPOSED_FROM_CURATOR_INVENTORY 2026-09-08 · seed_from_sources
Proposed from curation/curator_antibiotics.tsv

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

Explore across X-Mech: MediaIngredientMech (NSC348884) · CultureMech · NaturalProductMech · PathwayMech · TraitMech