oleandomycin
CHEBI:16869
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
Oleandomycin is a 14-membered macrolide produced by Streptomyces antibioticus. It is ssimilar to erythromycin, and contains a desosamine amino sugar and an oleandrose sugar. It targets the 50S ribosomal subunit to prevent protein synthesis. — PMID:13425352
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
macrolide antibioticARO:0000000
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C35H61NO12 |
|---|
| Charge | 0 |
|---|
| Average mass | 687.868 Da |
|---|
| Monoisotopic mass | 687.41938 Da |
|---|
| Source | ChEBI |
|---|
| InChIKey | RZPAKFUAFGMUPI-QESOVKLGSA-N |
|---|
SMILES
CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)C[C@@]3(CO3)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O
InChI
InChI=1S/C35H61NO12/c1-16-14-35(15-43-35)32(40)19(4)27(37)18(3)22(7)46-33(41)21(6)31(47-26-13-25(42-11)28(38)23(8)45-26)20(5)30(16)48-34-29(39)24(36(9)10)12-17(2)44-34/h16-31,34,37-39H,12-15H2,1-11H3/t16-,17+,18-,19+,20+,21+,22+,23-,24-,25-,26-,27-,28-,29+,30-,31-,34-,35+/m0/s1
Also called
- Amimycin (EXACT_SYNONYM)— aro
- Matromycin (EXACT_SYNONYM)— aro
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3000867 |
oleandomycin |
antibioticmech:aro-4ec68d2906 |
2026-08-30 |
Resistance mechanisms
30 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_ALTERATION 23
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Erm(33) |
ARO:3000599 |
not organism-specific |
— |
- ARO:3000599 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| Erm(34) |
ARO:3000600 |
not organism-specific |
— |
- ARO:3000600 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| Erm(35) |
ARO:3000604 |
not organism-specific |
— |
- ARO:3000604 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| Erm(36) |
ARO:3000605 |
not organism-specific |
— |
- ARO:3000605 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| Erm(37) |
ARO:3000392 |
not organism-specific |
— |
- ARO:3000392 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| Erm(38) |
ARO:3000601 |
not organism-specific |
— |
- ARO:3000601 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| Erm(39) |
ARO:3000602 |
not organism-specific |
— |
- ARO:3000602 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| Erm(41) |
ARO:3000603 |
not organism-specific |
— |
- ARO:3000603 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmA |
ARO:3000347 |
not organism-specific |
— |
- ARO:3000347 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmB |
ARO:3000375 |
not organism-specific |
— |
- ARO:3000375 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmC |
ARO:3000250 |
not organism-specific |
— |
- ARO:3000250 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmD |
ARO:3000495 |
not organism-specific |
— |
- ARO:3000495 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmE |
ARO:3000326 |
not organism-specific |
— |
- ARO:3000326 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmF |
ARO:3000498 |
not organism-specific |
— |
- ARO:3000498 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmG |
ARO:3000522 |
not organism-specific |
— |
- ARO:3000522 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmH |
ARO:3002823 |
not organism-specific |
— |
- ARO:3002823 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmN |
ARO:3000592 |
not organism-specific |
— |
- ARO:3000592 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmQ |
ARO:3000593 |
not organism-specific |
— |
- ARO:3000593 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmR |
ARO:3000594 |
not organism-specific |
— |
- ARO:3000594 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmT |
ARO:3000595 |
not organism-specific |
— |
- ARO:3000595 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmV |
ARO:3002824 |
not organism-specific |
— |
- ARO:3002824 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmX |
ARO:3000596 |
not organism-specific |
— |
- ARO:3000596 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| ErmY |
ARO:3002825 |
not organism-specific |
— |
- ARO:3002825 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
ANTIBIOTIC_INACTIVATION 5
ANTIBIOTIC_INACTIVATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| gimA |
ARO:3000463 |
not organism-specific |
— |
- ARO:3000463 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| mphA |
ARO:3000316 |
not organism-specific |
— |
- ARO:3000316 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| mphB |
ARO:3000318 |
not organism-specific |
— |
- ARO:3000318 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| mphC |
ARO:3000319 |
not organism-specific |
— |
- ARO:3000319 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
| oleI |
ARO:3000866 |
not organism-specific |
— |
- ARO:3000866 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
ANTIBIOTIC_EFFLUX 1
ANTIBIOTIC_EFFLUX
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| oleC |
ARO:3003748 |
not organism-specific |
— |
- ARO:3003748 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
ANTIBIOTIC_TARGET_PROTECTION 1
ANTIBIOTIC_TARGET_PROTECTION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| oleB |
ARO:3003036 |
not organism-specific |
— |
- ARO:3003036 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000867 (oleandomycin); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.